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| Status |
Public on Aug 31, 2016 |
| Title |
Loss of beta-catenin triggers oxidative stress and impairs hematopoietic regeneration |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Accidental or deliberate ionizing radiation exposure is fatal due to widespread hematopoietic destruction. However, little is known about either the course of injury or the definitive molecular pathways that regulate the subsequent regenerative response. We have investigated the spatial and temporal consequences of radiation injury on the hematopoietic system and show the Wnt signaling pathway is critially important for regeneration.
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| Overall design |
Sorted KLS34- hematopoietic stem cells from 3 control samples and 3 beta catenin floxed vav-Cre positive were analyzed.
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| Contributor(s) |
Lento W, Ito T, Zhao C, Harris JR, Jiang C, Owzar K, Chao N, Reya T |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Sep 05, 2013 |
| Last update date |
Sep 01, 2016 |
| Contact name |
William Lento |
| Organization name |
Duke University
|
| Department |
Medicine/Cellular Therapy
|
| Lab |
Nelson Chao MD
|
| Street address |
213 Research Drive
|
| City |
Durham |
| State/province |
NC |
| ZIP/Postal code |
27710 |
| Country |
USA |
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| Platforms (1) |
| GPL10740 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [probe set (exon) version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA218099 |
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