|
| Status |
Public on Mar 31, 2015 |
| Title |
Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function (Expression data from islets of control and Insm1 conditional deleted adult pancreatic islets) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The zinc finger factor Insm1 is known to regulate differentiation of pancreatic β cells during development, Here we show that Insm1 is essential for the maintenance of functionally mature pancreatic β cells in mice.
We used microarrays to analyse the global gene expression after deletion of insm1 in adult pancreatic β cells and identified functional important genes and immature islets releated genes deregulated in the mutatant islets.
|
| |
|
| Overall design |
We used 8 mutant and 8 litter matched control mice for the islets preparation.
|
| |
|
| Contributor(s) |
Jia S, Ivanov A |
| Citation(s) |
25828096 |
| |
| Submission date |
Jan 13, 2014 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Andranik Ivanov |
| E-mail(s) |
[email protected]
|
| Organization name |
Berlin Institute of Health
|
| Department |
Core Unit Bioinformatics
|
| Street address |
Chariteplatz 1
|
| City |
Berlin |
| ZIP/Postal code |
10117 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (16)
|
|
| Relations |
| BioProject |
PRJNA236025 |
Less...
More...