|
| Status |
Public on Mar 11, 2014 |
| Title |
Esophageal Cancer Project |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by genome tiling array
|
| Summary |
Esophageal cancer is one of the most aggressive cancers and the sixth leading cause of cancer death worldwide. Approximately 70% of the global esophageal cancers occur in China and over 90% histopathological forms of this disease are esophageal squamous cell carcinoma (ESCC). Currently, there are limited clinical approaches for early diagnosis and treatment for ESCC, resulting in a 10% 5-year survival rate for the patients. Meanwhile, the full repertoire of genomic events leading to the pathogenesis of ESCC remains unclear. Here we show a comprehensive genomic analysis in 158 ESCC cases, as part of the International Cancer Genome Consortium (ICGC) Research Projects (http://icgc.org/icgc/cgp/72/371/1001734). We conducted whole-genome sequencing in 17 ESCC cases and whole-exome sequencing in 71 cases, of which 53 cases and additional 70 ESCC cases were subjected to array comparative genomic hybridization (a-CGH) analysis.
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| |
|
| Overall design |
We conducted whole-genome sequencing in 17 ESCC cases and whole-exome sequencing in 71 cases, of which 53 cases and additional 70 ESCC cases were subjected to array comparative genomic hybridization (a-CGH) analysis.
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| |
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| Citation(s) |
24670651 |
| |
| Submission date |
Feb 13, 2014 |
| Last update date |
Apr 25, 2014 |
| Contact name |
Lin Li |
| E-mail(s) |
[email protected]
|
| Organization name |
BGI
|
| Street address |
Beishan Industrial Zone
|
| City |
shenzhen |
| ZIP/Postal code |
518083 |
| Country |
China |
| |
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| Platforms (2) |
| GPL8736 |
Agilent-021529 Human CGH Whole Genome Microarray 1x1M (G4447A) (Feature Number version) |
| GPL15436 |
NimbleGen Human CGH 3x720K Whole-Genome Tiling v3.0 Array [090527_HG18_WG_CGH_v3.1_HX3] |
|
| Samples (123)
|
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| This SuperSeries is composed of the following SubSeries: |
| GSE54993 |
a-CGH of Esophageal Cancer (70 cases) |
| GSE54994 |
a-CGH of Esophageal Cancer (53 cases) |
|
| Relations |
| BioProject |
PRJNA238218 |
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