|
| Status |
Public on Feb 28, 2015 |
| Title |
LncRNAs expression profiling in adipose tissues and during brown adipocyte differentiation |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
Brown and beige fats generate heat via uncoupled respiration to defend against cold, mechanistically, through the action of a network of transcription factors and cofactors. Here we globally profiled long noncoding RNAs (lncRNAs) gene expression during thermogenic adipocyte formation and identified Brown fat lncRNA 1 (Blnc1) as a novel nuclear lncRNA that promotes brown and beige adipocyte differentiation and function by forming a feedforward regulatory loop with EBF2 to drive adipogenesis toward thermogenic phenotype.
|
| |
|
| Overall design |
LncRNAs expression were measured in BAT and WAT from mice injected saline/CL and during brown adipocyte differentiation with two replicates using Arraystar Mouse LncRNA microarray V2.0
|
| |
|
| Contributor(s) |
Zhao X, Li S, Wang G, Yu Q, Lin JD |
| Citation(s) |
25002143 |
| |
| Submission date |
May 13, 2014 |
| Last update date |
Mar 03, 2016 |
| Contact name |
xuyun zhao |
| E-mail(s) |
[email protected]
|
| Organization name |
Life Sciences Institute
|
| Street address |
210 washtenaw ave
|
| City |
Ann Arbor |
| State/province |
Michigan |
| ZIP/Postal code |
48109 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL15691 |
034068 Arraystar Mouse LncRNA microarray V2.0 |
|
| Samples (10)
|
| GSM1385875 |
Brown adipose tissue from saline injected mice, biological rep1 |
| GSM1385876 |
Brown adipose tissue from saline injected mice, biological rep2 |
| GSM1385877 |
White adipose tissue from saline injected mice, biological rep1 |
| GSM1385878 |
White adipose tissue from saline injected mice, biological rep2 |
| GSM1385879 |
White adipose tissue from CL injected mice, biological rep1 |
| GSM1385880 |
White adipose tissue from CL injected mice, biological rep2 |
| GSM1385881 |
Brown adipocytes differentiation day 0 |
| GSM1385882 |
Brown adipocytes differentiation day 3 |
| GSM1385883 |
Brown adipocytes differentiation day 5 |
| GSM1385884 |
Brown adipocytes differentiation day 7 |
|
| Relations |
| BioProject |
PRJNA247393 |
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