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| Status |
Public on Aug 20, 2014 |
| Title |
T cell-intrinsic MyD88 signaling in cognate immune response to intracellular parasite infection: crucial role for IL-18R |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We compared gene expression between WT CD4+ (CD45.1) and Myd88-/- CD4+ (CD45.2) T cells from the spleen of infected mix bone marrow chimeras at day 14 of T. cruzi infection. The hypothesis studied in this experiment was that MyD88-/- CD4+ cells have suppressed Th1 differentiation potencial when compared to WT CD4+ T cells. The results indicate that CD4+ T cell-intrinsic MyD88 signaling is necessary for sustaining a more robust Th1 differentiation program and increased expansion among WT CD4+ T cells, resultant of relative higher proliferation and lower apoptosis
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| Overall design |
Total RNA obtained from isolated CD4+ T cells from the spleen of infected mix bone marrow chimeras at day 14 of T. cruzi infection.
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| Contributor(s) |
Reis BS, Bellio M, Nakaya HI, Nóbrega A |
| Citation(s) |
28895840, 35670567 |
| |
| Submission date |
May 16, 2014 |
| Last update date |
Jul 07, 2022 |
| Contact name |
Bernardo Reis |
| E-mail(s) |
[email protected]
|
| Organization name |
Rockefeller University
|
| Street address |
1234 York Avenue
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
|
| Samples (4)
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| GSM1387888 |
sorted spleenic MyD88-/- CD4+ T cells rep2 |
|
| Relations |
| BioProject |
PRJNA247979 |
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