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| Status |
Public on Jan 06, 2015 |
| Title |
Distinct gene signatures define pathogen- versus diet-induced atherosclerosis development |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The goal of this study was to define gene expression profiles in aortic tissue in response to three pro-atherogenic stimuli at two time points. We identified gene expression profiles induced by oral P.gingivalis (Pg), intranasal C. pneumoniae (Cp), and Western diet (WD) at acute (1 day after last infection, Pg, Cp, and control groups) and chronic (9 weeks after last infection, Pg, Cp, and control groups; WD for 9 weeks) time points in aortas of Apolipoprotein E (Apoe-/-) mice. 3 replicates per group were analyzed. RNA was analyzed using Mouse Gene 1.0 ST Array (Affymetrix, Santa Clara, CA).
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| |
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| Overall design |
Total RNA from aortic tissue of Apoe-/- mice treated with P. gingivalis, C. pneumoniae, or fed a Western diet were compared to controls at acute and chronic time points.
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| |
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| Contributor(s) |
Kramer C, Weinberg E |
| Citation(s) |
25540039 |
| |
| Submission date |
Aug 05, 2014 |
| Last update date |
Jun 25, 2019 |
| Contact name |
Boston University Microarray and Sequencing Resource |
| E-mail(s) |
[email protected]
|
| Organization name |
Boston University
|
| Department |
Microarray and Sequencing Resource
|
| Street address |
72 East Concord Street, E631
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02118 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL13730 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [CDF: MoGene10stv1_Mm_ENTREZG_14.1.0] |
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| Samples (21)
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| Relations |
| BioProject |
PRJNA257453 |
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