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| Status |
Public on Oct 27, 2015 |
| Title |
Effect of YAP overexpression on HuCCT1 cholangiocarcinoma cell line transcriptome (shRNA targeting YAP) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The YAP pathway in regulating organ size by integrating external signals to control the expression of genes involved in cell proliferation. YAP is known to be involved in tumorigenesis in several tissues, yet its role in cholangiocarcinoma is not established
We used microarrays to assess the role of YAP pathway in cholangiocarcinoma either by overexpressing a constitutively active YAP1 mutant, or by downregulating YAP1 expression using shRNA
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| Overall design |
HuCCT1 cells where transfected with either a control scrambled shRNA or a shRNA targeting YAP1; cells were harvested, RNA was collected and analyzed using microarray
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| Contributor(s) |
Marti P, Blumer T, Dill MT, Abraham Y, Stein C, Megel P, Jurisic G, Makowska Z, Pikiolek M, Orsini V, Agarinis C, Tornillo L, Bouwmeester T, Ruffner H, Bauer A, Schmelzle T, Parker C, Terracciano LM, Heim MH, Tchorz JS |
| Citation(s) |
26173433 |
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| Submission date |
Sep 25, 2014 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Yann Abraham |
| Organization name |
Novartis Pharma AG
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| Department |
NIBR/DMP
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| Street address |
Postfach
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| City |
Basel |
| ZIP/Postal code |
CH-4002 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE61767 |
Effect of YAP overexpression on HuCCT1 cholangiocarcinoma cell line transcriptome |
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| Relations |
| BioProject |
PRJNA262082 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE61765_RAW.tar |
40.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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