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| Status |
Public on Dec 01, 2006 |
| Title |
Murine model of decidulization and menstruation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
A murine model that mimic the decidualization and regression observed in human was used to investigate the molecular mechanisms underlying the dynamic processes in endometrium. Ovariectomized mice were treated sequentially with steroid hormones and then, to induce decidualization, oil was injected into the uterine lumen. A process similar to menstruation was induced by hormone-withdrawal. The uterine tissues were collected at 4 time-points after the induction of decidualization.
Keywords: decidualization, menstruation, progesterone-withdrawal, time-course
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| Overall design |
The uterine tissues were collected at 36 (T1), 48 (T2), 60 (T3) and 84 hours (T4) after the last progesterone injection. There are 4 experimental animals for each time-point, and the RNAs collected from animals within the same time-point group were pooled together for Affymetrix microarray analysis using U74Av2 Chips.
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| Contributor(s) |
Cheng C, Bielby H, Licence D, Smith SK, Print CG, Charnock-Jones D |
| Citation(s) |
17251523 |
| |
| Submission date |
Nov 23, 2006 |
| Last update date |
Feb 18, 2018 |
| Contact name |
Ching-wen Cheng |
| E-mail(s) |
[email protected]
|
| Phone |
01223-762321
|
| Organization name |
University of Cambridge
|
| Department |
Obstetrics and Gynaecology
|
| Street address |
Robinson Way
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| City |
Cambridge |
| ZIP/Postal code |
CB2 2SW |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
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| Samples (4)
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| GSM146831 |
Uterus Menstruating Progesterone withdrawn T1 |
| GSM146924 |
Uterus Menstruating Progesterone withdrawn T2 |
| GSM146925 |
Uterus Menstruating Progesterone withdrawn T3 |
| GSM146926 |
Uterus Menstruating Progesterone withdrawn T4 |
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| Relations |
| BioProject |
PRJNA99569 |
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