|
| Status |
Public on Sep 01, 2016 |
| Title |
Histone genes transcription regulators binding in human cancer (U2OS) and normal (hTERT-RPE1) cells |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
The regulation of replication-dependent histone genes by CASP8AP2 and NPAT is likely direct, based on ChIP-seq. CASP8AP2 and NPAT ChIP-Seq peaks were enriched near transcription start sites (TSSs) of replication-dependent, but not replication-independent histone genes on chromosomes 1, 6 and 12 in both cell lines. HINFP ChIP-Seq peaks were enriched near transcription start sites (TSSs) of replication-dependent histone genes H4 and H2B and replication-independent histone genes H1FX and H1F0 in both cell lines. Another histone gene regulator, E2F1 also bound to TSSs of many histone genes mainly replication-independent.
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| |
|
| Overall design |
Examination of histone genes transcroption regulators binding by ChIP-seq in normal and cancer cell lines
|
| |
|
| Contributor(s) |
Sokolova M, Turunen M |
| Citation(s) |
27929715 |
| |
| Submission date |
May 21, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Maria Sokolova |
| E-mail(s) |
[email protected]
|
| Organization name |
University of Helsinki
|
| Department |
Institute of Biotechnology
|
| Lab |
Nuclear Actin Lab
|
| Street address |
Viikinkaari 5
|
| City |
Helsinki |
| ZIP/Postal code |
00014 |
| Country |
Finland |
| |
|
| Platforms (2) |
| GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (12)
|
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| This SubSeries is part of SuperSeries: |
| GSE69149 |
Histone gene regulation in normal and tumor cells |
|
| Relations |
| BioProject |
PRJNA284642 |
| SRA |
SRP058604 |
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