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| Status |
Public on Nov 01, 2007 |
| Title |
Gene Expression Profiling in Peripheral Blood in Untreated New Onset Systemic Juvenile Idiopathic Arthritis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Systemic Juvenile Idiopathic Arthritis (sJIA) has been strongly associated with macrophage activation syndrome (MAS). To better understand the pathogenesid of sJIA and to facilitate the search for MAS biomarkers, we examine gene expression profiles in untreated new onset sJIA.
17 new onset sJIA patients were included in the study. 5 of the 17 patients showed evidence of subclinical MAS and 2 eventually developed overt MAS.
Keywords: disease versus control
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| Overall design |
Peripheral blood mononuclear cells (PBMCs) were separated using a Ficoll gradient from the 17 new onset sJIA patients and 30 normal control. RNA was extracted from the PBMCS and subsequently hybridized to Affymetrix microarrays
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| Contributor(s) |
Fall N, Barnes M, Thornton S, Luyrink L, Jennings K, Olson J, Ilowit N, Griffin T, Sherry D, Thompson S, Glass D, Colbert R, Grom A |
| Citation(s) |
17968951 |
| |
| Submission date |
May 07, 2007 |
| Last update date |
Mar 25, 2019 |
| Contact name |
ndate fall |
| E-mail(s) |
[email protected]
|
| Phone |
513-636-7663
|
| Organization name |
Cincinnati children's hospital medical center
|
| Department |
rheumatology
|
| Street address |
3333 burnet av
|
| City |
cincinnati |
| State/province |
OH |
| ZIP/Postal code |
45229 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (47)
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| Relations |
| BioProject |
PRJNA99875 |
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