|
| Status |
Public on Mar 01, 2016 |
| Title |
Expression data from adult mouse Nucleus Accumbens following prenatal infection |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Prenatal exposure to infectious or inflammatory insults can increase the risk of neuropsychiatric disorders with neurodevelopmental components, including schizophrenia and autism. The molecular processes underlying this pathological association are only partially understood. Here, we implemented an unbiased genome-wide transcriptional profiling of the nucleus accumbens of mice exposed to prenatal infection on GD17 compared to control subjects in order to elucidate the long term molecular signature of late prenatal infection.
We used microarray analysis to investigate the long lasting gene expression changes in a well-established mouse model that is based on maternal treatment with the viral mimic poly(I:C) during pregnancy
|
| |
|
| Overall design |
C57BL/6 mice were treated with the synthetic viral mimetic poly(I:C) (5 mg/kg, i.v.) or control (saline, i.v.) solution on gestation day 17. Offspring were subjected to cognitive and behavioral testing in adulthood, and then whole genome gene expression analysis with Affymetrix Microarray and subsequent q-PCR validation were performed on the nucleus accumbens.
|
| |
|
| Contributor(s) |
Richetto J, Meyer U, Riva MA, Cattaneo A |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Feb 16, 2016 |
| Last update date |
Apr 18, 2017 |
| Contact name |
Juliet Richetto |
| E-mail(s) |
[email protected]
|
| Organization name |
University of Zurich - Vetsuisse
|
| Department |
Institute for Pharmacology and Toxicology
|
| Street address |
Winterthurerstrasse 260
|
| City |
Zurich |
| ZIP/Postal code |
8057 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL11533 |
[MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version] |
|
| Samples (12)
|
| GSM2063006 |
Nac control offspring, biological replicate 1 |
| GSM2063007 |
Nac control offspring, biological replicate 2 |
| GSM2063008 |
Nac control offspring, biological replicate 3 |
| GSM2063009 |
Nac control offspring, biological replicate 4 |
| GSM2063010 |
Nac control offspring, biological replicate 5 |
| GSM2063011 |
Nac control offspring, biological replicate 6 |
| GSM2063012 |
Nac PolyI:C offspring, biological replicate 1 |
| GSM2063013 |
Nac PolyI:C offspring, biological replicate 2 |
| GSM2063014 |
Nac PolyI:C offspring, biological replicate 3 |
| GSM2063015 |
Nac PolyI:C offspring, biological replicate 4 |
| GSM2063016 |
Nac PolyI:C offspring, biological replicate 5 |
| GSM2063017 |
Nac PolyI:C offspring, biological replicate 6 |
|
| This SubSeries is part of SuperSeries: |
| GSE77973 |
Expression data from adult mouse brain regions following prenatal infection |
|
| Relations |
| BioProject |
PRJNA312224 |
Less...
More...