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| Status |
Public on Jan 24, 2017 |
| Title |
Expression data from LPS/IFNgamma-treated Tet2-/- and Tet2+/+ mouse macrophages. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We examined the effect of ablation of Tet2, an epigenetic regulator of gene transcription, in the global programme of gene expression underlying pro-inflammatory activation of macrophage.
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| Overall design |
Thioglycllate-elicted macrophages were isolated from the Tet2 -/- mice and their wildtype littermates (N=3/group), treated with LPS and IFNg for 10 hours, and isolated for total RNA. Whole-genome transcript profiling was performed using Affymetrix microarray to identify genes that were dysregulated due to Tet2 ablation under the inflammation stimuli.
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| Contributor(s) |
Fuster JJ, Wu C, Walsh K |
| Citation(s) |
28104796 |
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| Submission date |
May 12, 2016 |
| Last update date |
Mar 07, 2017 |
| Contact name |
Chia-Ling Wu |
| E-mail(s) |
[email protected]
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| Organization name |
Boston University
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| Department |
Whitaker Cardiovascular Institute
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| Lab |
Walsh
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| Street address |
700Albany St
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| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02118 |
| Country |
USA |
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| Platforms (1) |
| GPL17791 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [mogene20st_Mm_ENTREZG_17.1.0] |
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| Samples (6)
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| GSM2151848 |
Tet2 deficient macrophage, biological replicate 1 |
| GSM2151849 |
Wildtype macrophage, biological replicate 1 |
| GSM2151850 |
Tet2 deficient macrophage, biological replicate 2 |
| GSM2151851 |
Wildtype macrophage, biological replicate 2 |
| GSM2151852 |
Tet2 deficient macrophage, biological replicate 3 |
| GSM2151853 |
Wildtype macrophage, biological replicate 3 |
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| Relations |
| BioProject |
PRJNA321440 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE81398_RAW.tar |
65.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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