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| Status |
Public on Mar 14, 2017 |
| Title |
Krüppel-like Transcription Factor-10 (KLF10) Provides a Negative Feedback Mechanism to Suppress TGFβ-Induced Epithelial-to-Mesenchymal Transition [RNA-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We examined transcriptome-wide effects of pertrurbation in KLF10 function (siKLF10) on TGFβ-regulated genes and EMT in two different cells lines: A549 and Panc1.
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| Overall design |
We performed mRNA sequencing from A549 and Panc1 cells following following TGFβ treatment and KLF10 knockdown. The mRNA-Seq includes following conditions: siControl, siKLF10, TGFβ, siKLF10+TGFβ (A549 and Panc1 cells). mRNA-sequencing was performed in duplicates for A549 and triplicates for Panc1 cells.
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| Contributor(s) |
Johnsen SA, Mishra VK |
| Citation(s) |
28249899 |
| |
| Submission date |
Nov 28, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Steven A. Johnsen |
| Organization name |
University Medical Center Goettingen
|
| Department |
Department of General, Visceral and Pediatric Surgery
|
| Lab |
AG Johnsen/Tumorepigenetics
|
| Street address |
Robert-Koch-Straße 40
|
| City |
Goettingen |
| ZIP/Postal code |
37075 |
| Country |
Germany |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (20)
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| This SubSeries is part of SuperSeries: |
| GSE90567 |
Krüppel-like Transcription Factor-10 (KLF10) Provides a Negative Feedback Mechanism to Suppress TGFβ-Induced Epithelial-to-Mesenchymal Transition |
|
| Relations |
| BioProject |
PRJNA355089 |
| SRA |
SRP093988 |
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