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| Status |
Public on Nov 26, 2018 |
| Title |
Annotation and functional clustering of circRNA expression in rhesus macaque brain during aging |
| Organism |
Macaca mulatta |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
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| Summary |
The abundance and function of circular RNAs (circRNAs) in mammalian brain have been reported, but their alterations in the biology of brain aging remain elusive. Here, using deep RNA profiling with linear RNA digestion by RNase R we explored a comprehensive map of changes in circRNA expression in rhesus macaque (macaca mulatta) brain in two age groups from adult (10 y) to aged (20 y) periods. Total 17,050 well expressed, stable circRNAs were identified. Cluster analysis reveals that dynamic changes in circRNA expression show the spatial-, sex- and age-biased specificities. On the basis of separate profiling of the RNAs, age-related circRNAs show differential correlation to host mRNA expression. Furthermore, two voltage-dependent L- and R-type calcium channel gene-derived circCACNA2D1 and circCACNA1E negatively regulate their host mRNA expression. Our results demonstrate the power of changes in circRNA expression to reveal insights into a potentially circRNA-mediated regulatory mechanism underlying the biology of brain aging.
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| Overall design |
Examination of 8 different brain regions in Rhesus Macaque across the two ages ( 10- and 20-year old )
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| Contributor(s) |
Li J, Zhang Y |
| Citation(s) |
30245844, 32681011 |
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| Submission date |
Jan 24, 2017 |
| Last update date |
Jul 27, 2020 |
| Contact name |
dong chen |
| Organization name |
ablife
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| Street address |
GaoXin 2nd Road
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| City |
wuhan |
| State/province |
Hubei |
| ZIP/Postal code |
430064 |
| Country |
China |
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| Platforms (1) |
| GPL21120 |
Illumina NextSeq 500 (Macaca mulatta) |
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| Samples (32)
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| Relations |
| BioProject |
PRJNA363074 |
| SRA |
SRP097707 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE94027_circRNA_TPM_by_sj_anno.txt.gz |
2.3 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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