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Series GSE94349 Query DataSets for GSE94349
Status Public on Feb 01, 2017
Title Molecular analyses reveal an inflammatory response in the solid component and cystic fluid of human adamantinomatous craniopharyngioma
Organism Homo sapiens
Experiment type Expression profiling by array
Third-party reanalysis
Summary Pediatric adamantinomatous craniopharyngioma (ACP) cyst may be associated with injury to critical neurological structures, such as the hypothalamus, resulting in poor quality of life and shorter lifespan. This work presents evidence that immune actors, both pro-inflammatory and immunomodulatory, and their receptors, are present at unique levels in ACP cyst fluid and tumor tissue, potentially indicating a mechanism underlying cyst growth and tumor invasion of the hypothalamus.
Transcriptomic analysis revealed that ACP, when compared to other pediatric brain tumors and nomral brain, harbored overexpression of a number of inflammatory and immunosuppressive genes.
 
Overall design Gene expression profiles were generated from ACP surgical tumor, and surgical tumors of other common pediatric brain tumor types and normal brain samples (n=110) using Affymetrix HG-U133plus2 chips (Platform GPL570).
 
Contributor(s) Donson AM
Citation(s) 28859336
Submission date Jan 31, 2017
Last update date Jun 18, 2019
Contact name Andrew M Donson
E-mail(s) [email protected]
Phone 303 724 4012
Organization name CU Anschutz Medical Campus
Department Pediatrics
Lab RC1 North, P18-4401M
Street address 12800 E 19th Ave
City Aurora
State/province CO
ZIP/Postal code 80010
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (168)
GSM2473601 ACP_AB00009_1_AMBION; reanalysis of GSM1660985
GSM2473602 ACP_CB00001_AMBION; reanalysis of GSM1660986
GSM2473603 ACP_CB00002_AMBION; reanalysis of GSM1660987
Relations
Reanalysis of GSM663736
Reanalysis of GSM663737
Reanalysis of GSM663738
Reanalysis of GSM663739
Reanalysis of GSM663740
Reanalysis of GSM663741
Reanalysis of GSM663742
Reanalysis of GSM663743
Reanalysis of GSM663744
Reanalysis of GSM663745
Reanalysis of GSM663746
Reanalysis of GSM663747
Reanalysis of GSM663748
Reanalysis of GSM663749
Reanalysis of GSM663750
Reanalysis of GSM663751
Reanalysis of GSM663752
Reanalysis of GSM663753
Reanalysis of GSM663754
Reanalysis of GSM663755
Reanalysis of GSM663756
Reanalysis of GSM663757
Reanalysis of GSM663758
BioProject PRJNA369432

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE94349_RAW.tar 946.9 Mb (http)(custom) TAR (of CEL)
GSE94349_complete_processed_data.txt.gz 54.1 Mb (ftp)(http) TXT
GSE94349_complete_sample_metdata.txt.gz 1.9 Kb (ftp)(http) TXT
Processed data included within Sample table
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