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| Status |
Public on Sep 27, 2017 |
| Title |
Transcriptomic profile of circulating naïve, TCM, TEM and TEMRA T cells in donors from Sri Lanka previously exposed to dengue virus and healthy controls from San Diego [Cohort 2 & Cohort 3] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Dengue virus is responsible for 400 million human infections each year . The characterization of exact molecular components of immune response associated may help design more effective therapeutic interventions. In this study, we aimed to characterize the immune signature of T cells subtypes associated with previous exposure to dengue virus. Transcriptomic profiling using RNA sequencing was performed on naive, TCM, TEM and TEMRA CD4 T cells isolated from individuals with secondary dengue infections from Sri Lanka, an endemic area, as well as from dengue negative healthy controls.
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| |
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| Overall design |
RNA-sequencing of sorted CD4 naïve, TCM, TEM and TEMRA T cells from cryopreserved PBMC of 5 subjects with secondary infection infection and 6 dengue virus negative healthy controls.
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| Contributor(s) |
Weiskopf D, Tian Y, Babor M, O'Rourke P, Seumois G, Fu Z, Greenbaum J, Peters B, Vijayanand P, Sette A |
| Citation(s) |
29133794 |
| |
| Submission date |
Apr 17, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Mariana Babor |
| E-mail(s) |
[email protected]
|
| Organization name |
La Jolla Institute for Allergy and Immunology
|
| Street address |
9420 Athena Cir
|
| City |
La Jolla |
| ZIP/Postal code |
92037 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (44)
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| This SubSeries is part of SuperSeries: |
| GSE97863 |
Transcriptomic profile of circulating naïve, TCM, TEM and TEMRA T cells in donors from Sri Lanka previously exposed to dengue virus and healthy controls |
|
| Relations |
| BioProject |
PRJNA383116 |
| SRA |
SRP104125 |
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