hepatocellular carcinoma cell lines hcc-1.2 and hcc-1.1 cells, referred to as 3p and 3sp cells, respectively, were isolated from one hcc patient as described ( sagmeister s, eisenbauer m, pirker c, et al. new cellular tools reveal complex epithelial-mesenchymal interactions in hepatocarcinogenesis. br j cancer 2008;99(1): 151-9.). 3p cells of passages 10 to 12 and 3sp cells of passages 7 to 13 are termed 3p early and 3sp early, respectively. 3p cells between passage 71 and 76 and 3sp from passage 72 to 87 were termed 3p late and 3sp late, respectively