|
| Status |
Public on Apr 18, 2012 |
| Title |
B cell Acute Lymphoblastic Leukemia S162 |
| Sample type |
genomic |
| |
|
| Source name |
The same B cell ALL as LALB obtained from the spleen of mouse treated with 5mg/Kg of LBH589
|
| Organism |
Homo sapiens |
| Characteristics |
gender: Male
tissue: Peripheral Blood
cell type: B cell ALL
|
| Treatment protocol |
treatment was initiated 24 hours after injection of leukemic cells and included 3 cycles of 5 consecutive days of LBH589 with 2 days of rest between cycles.
|
| Growth protocol |
Samples S421, S739, S1 and S226 have been obtained from spleen of immunodeficient mice.
|
| Extracted molecule |
genomic DNA |
| Extraction protocol |
genomic DNA was extracted using QIAmp DNA Mini Kit following the manufacturer´s instructions (Qiagen, Hilden, Germany).
|
| Label |
Cy5 and Cy3
|
| Label protocol |
Standard Illumina Protocol
|
| |
|
| Hybridization protocol |
bisulphite converted DNA was amplified, fragmented and hybridised to Illumina Infinium Human Methylation27 Beadchip using standard Illumina protocol
|
| Scan protocol |
Arrays were imaged using BeadArray Reader using standard recommended Illumina scanner setting
|
| Description |
ALL sample
|
| Data processing |
BeadStudio software v3.2
|
| |
|
| Submission date |
Jan 21, 2011 |
| Last update date |
Apr 18, 2012 |
| Contact name |
Xabier Agirre |
| E-mail(s) |
[email protected]
|
| Phone |
+34 948194700
|
| Organization name |
CIMA
|
| Department |
Oncology
|
| Street address |
Pio XII, 55
|
| City |
Pamplona |
| State/province |
Navarra |
| ZIP/Postal code |
31008 |
| Country |
Spain |
| |
|
| Platform ID |
GPL8490 |
| Series (2) |
| GSE26791 |
The HDAC inhibitor panobinostat (LBH589) inhibits Acute Lymphoblastic leukemia (ALL) in vitro and in vivo in a new characterized human ALL mice model (Illumina) |
| GSE26807 |
The HDAC inhibitor panobinostat (LBH589) inhibits Acute Lymphoblastic leukemia (ALL) in vitro and in vivo in a new characterized human ALL mice model |
|
