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GTR Home > Conditions/Phenotypes > Acute febrile neutrophilic dermatosis

Acute febrile neutrophilic dermatosis

Synonyms
Gomm Button disease; Sweet Syndrome
Modes of inheritance
Non-Mendelian inheritance (Orphanet)

Summary

Acute febrile neutrophilic dermatosis (AFND) is an autosomal dominant autoinflammatory disorder characterized by onset of recurrent fever and dermatologic abnormalities in childhood. Laboratory studies show elevated acute-phase reactants and activation of the inflammatory response, particularly IL1B (147720). Additional more variable features may include myalgia and arthralgia (summary by Masters et al., 2016). [from OMIM]

Available tests

13 tests are in the database for this condition.

Check Related conditions for additional relevant tests.

Clinical tests (13 available)

Molecular Genetics Tests

Genes See tests for all associated and related genes

  • Also known as: FMF, MEF, PAAND, TRIM20, MEFV
    Summary: MEFV innate immunity regulator, pyrin

Clinical features

Help
Imported from Human Phenotype Ontology (HPO)

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