Pancreatic cancer, susceptibility to, 3

Synonyms: Pancreatic Cancer Susceptibility 3; Pancreatic cancer 3

Summary

Individuals with mutation in the PALB2 gene have an increased risk of developing pancreatic cancer. In addition, PALB2 variants increase susceptibility to several other cancers, e.g., familial breast-ovarian cancer (BROVCA5; 620422) (Jones et al., 2009; Yang et al., 2020). For background, phenotypic description, and a discussion of genetic heterogeneity of pancreatic carcinoma, see 260350. [from OMIM]

Available tests

85 tests are in the database for this condition.

Clinical tests (85 available)

Molecular Genetics Tests

Genes See tests for all associated and related genes

Associated genes Help
Genes reported to contribute to the condition.

PALB2
369 tests
Also known as: BROVCA5, FANCN, PNCA3, PALB2
Summary: partner and localizer of BRCA2

Imported from Human Phenotype Ontology (HPO)

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Abnormality of the digestive system
- Pancreatic adenocarcinoma
  Pancreatic adenocarcinoma
  - MedGen UID: 83800
  - Concept ID: C0281361
  - Finding: Neoplastic Process
  Abnormality of the digestive system
  See: Feature record | Search on this feature

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