PALB2 partner and localizer of BRCA2
Gene ID: 79728, updated on 27-Nov-2024Gene type: protein coding
Also known as: FANCN; PNCA3; BROVCA5
- See all available tests in GTR for this gene
- Go to complete Gene record for PALB2
- Go to Variation Viewer for PALB2 variants
Summary
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Breast-ovarian cancer, familial, susceptibility to, 5 | not available |
| Fanconi anemia complementation group N | See labs |
| Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. GeneReviews: Not available | |
| Hereditary cancer-predisposing syndrome MedGen: C0027672GeneReviews: Not available | See labs |
| Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. GeneReviews: Not available | |
| Pancreatic cancer, susceptibility to, 3 | See labs |
| Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. GeneReviews: Not available |
Genomic context
- Location:
- 16p12.2
- Sequence:
- Chromosome: 16; NC_000016.10 (23603165..23641310, complement)
- Total number of exons:
- 14
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for PALB2 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PALB2 database
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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