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Hemato-oncology chromosomal microarray
Clinical Genetic Test
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offered by
Pittsburgh Cytogenetics Laboratory
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GTR Test Accession: Help GTR000527837.1
CANCERINHERITED DISEASEINHERITED DISEASE SUSCEPTIBILITY ... View more
Registered in GTR: 2015-08-16
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Last annual review date for the lab: 2024-05-22 LinkOut
At a Glance
Test purpose: Help
Diagnosis; Prognostic; Risk Assessment; ...
Conditions (23): Help
Neuroblastoma; Acute lymphoid leukemia; Basal cell carcinoma, susceptibility to, 1 more...
Chromosomal regions/ Mitochondria (1): Help
1q, 3p21, 5q31
Genes (92): Help
ABI1 (10p12.1); ACSL3 (2q36.1); AKT1 (14q32.33); AKT2 (19q13.2); ALK (2p23.2-23.1) more...
Methods (2): Help
Molecular Genetics - Deletion/duplication analysis: Microarray; ...
Target population: Help
Not provided
Clinical validity: Help
Not provided
Clinical utility: Help
Not provided
Ordering Information
Offered by: Help
Pittsburgh Cytogenetics Laboratory
View lab's website
View lab's test page
Test short name: Help
Kancerray
Specimen Source: Help
  • Bone marrow
  • Frozen tissue
  • Isolated DNA
  • tumor biopsy
  • Peripheral (whole) blood
Who can order: Help
  • Health Care Provider
How to Order: Help
For more information, please contact the laboratory directly.
Informed consent required: Help
Decline to answer
Pre-test genetic counseling required: Help
Decline to answer
Post-test genetic counseling required: Help
Decline to answer
Recommended fields not provided:
Test Order Code, Lab contact for this test, Contact policy, Test strategy, Test development
Conditions Help
Total conditions: 23
Condition/Phenotype Identifier
Test Targets
Chromosomal regions/Mitochondria Help
Total chromosomal regions/mitochondria: 1
Chromosomal region/Mitochondrion Associated condition
Genes Help
Total genes: 92
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Methodology
Total methods: 2
Method Category Help
Test method Help
Instrument *
Deletion/duplication analysis
Microarray
Detection of homozygosity
Microarray
* Instrument: Not provided
Clinical Information
Test purpose: Help
Diagnosis; Prognostic; Risk Assessment; Therapeutic management
Recommended fields not provided:
Clinical validity, Clinical utility, Target population, What is the protocol for interpreting a variation as a VUS?, Are family members with defined clinical status recruited to assess significance of VUS without charge?, Will the lab re-contact the ordering physician if variant interpretation changes?, Is research allowed on the sample after clinical testing is complete?, Sample negative report, Sample positive report
Technical Information
Test Comments: Help
For a specific gene information, please contact the laboratory directly.
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
This test is evaluated for analytical validity using an established validation process utilizing abnormal and normal specimens as per CAP, ACMG, and CLIA guidelines. Microarray platform includes oligonucleotide probes for the 898 genes known to be involved in carcinogenesis, subtelomeric, pericentromeric regions, as well as breakpoint “hot spot” intervals associated … View more
Assay limitations: Help
Although microarray detects microscopic and submicroscopic deletions and duplications undetectable by karyotyping, microarray will not detect balanced chromosome rearrangements, such as balanced translocations or inversions. It will not detect alterations in chromosome structure at areas of the genome not covered by the array. This technology will not detect sequence alterations … View more
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
No

Description of internal test validation method: Help
Karyotype, FISH analysis
Recommended fields not provided:
Test Confirmation, Citations to support assay limitations, Citations for Analytical validity, PT Provider, Description of PT method, Major CAP category, CAP category, CAP test list
Regulatory Approval
FDA Review: Help
Not provided
Additional Information

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