Classic view of this page
HVA/VMA
Clinical Genetic Test
Help
offered by
University of Minnesota Physicians Outreach Labs
GTR Test Accession: Help GTR000613176.2
CAP
ENDOCRINOLOGY
Last updated in GTR: 2024-12-19
View version history
Last annual review date for the lab: 2024-12-19 LinkOut
At a Glance
Test purpose: Help
Diagnosis; Monitoring
Conditions (1): Help
Hereditary pheochromocytoma-paraganglioma
Analytes (1): Help
Homovanillic acid (HVA) and Vanillylmandelic acid (VMA)
Methods (1): Help
Biochemical Genetics - Analyte: Gas chromatography–mass spectrometry (GC-MS)
Target population: Help
Not provided
Clinical validity: Help
Diagnosis and monitoring treatment of neuroblastoma and pheochromocytoma. The combination …
Clinical utility: Help
Establish or confirm diagnosis
Ordering Information
Offered by: Help
University of Minnesota Physicians Outreach Labs
View lab's website
Test short name: Help
HVMA
Specimen Source: Help
  • Urine collected on one 10 X 10 cm absorbent filter paper
  • Urine
Who can order: Help
  • Genetic Counselor
  • Licensed Physician
  • Nurse Practitioner
  • Physician Assistant
Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
Urine, random collection, 24 hr collection, or urine absorbed onto filter paper
If using filter paper to obtain collection, obtain filter paper urine collection kit from the Biochemical Genetics Laboratory. Order Code: LAB6334
For additional information, use the url to the Lab website.
Order URL
Test service: Help
Biochemical Genetics
    Comment: Abbrev Code: HVMA (includes HVA and VMA)
    OrderCode: LAB6334
Informed consent required: Help
No
Pre-test genetic counseling required: Help
No
Post-test genetic counseling required: Help
No
Recommended fields not provided:
Test Order Code, Lab contact for this test, Test strategy, Test development
Conditions Help
Total conditions: 1
Condition/Phenotype Identifier
Test Targets
Analytes Help
Total analytes: 1
Analyte Associated Condition
Methodology
Total methods: 1
Method Category Help
Test method Help
Instrument
Analyte
Gas chromatography–mass spectrometry (GC-MS)
Waters Xevo
Clinical Information
Test purpose: Help
Diagnosis; Monitoring
Clinical validity: Help
Diagnosis and monitoring treatment of neuroblastoma and pheochromocytoma. The combination of HVA and VMA will give a positive diagnosis in 92% of cases of neuroblastoma. More than 90% of patients with pheochromocytoma will have an elevated VMA. If both VMA and metanephrines are tested, >98% of patients with pheochromocytomas will … View more
Clinical utility: Help
Establish or confirm diagnosis
View citations (1)
  • https://www.testmenu.com/fairview/Tests/1203151

Variant Interpretation:
Are family members with defined clinical status recruited to assess significance of VUS without charge? Help
No.

Will the lab re-contact the ordering physician if variant interpretation changes? Help
Yes.
Sample reports:
Sample Negative Report Help
Sample Negative Report

Sample Positive Report Help
Sample Positive Report
Recommended fields not provided:
Target population, What is the protocol for interpreting a variation as a VUS?, Is research allowed on the sample after clinical testing is complete?
Technical Information
Test Procedure: Help
Gas chromatography/Mass spectrometry
Test Platform:
None/not applicable
Test Comments: Help
Drugs such as L-dopa, dopamine, epinephrine and norepinephrine are metabolized to HVA and VMA and will fictitiously elevate their levels in the urine. Therefore, the patient should not be on such drugs when collecting the urine.
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
Diagnosis and monitoring treatment of neuroblastoma and pheochromocytoma. The combination of HVA and VMA will give a positive diagnosis in 92% of cases of neuroblastoma. More than 90% of patients with pheochromocytoma will have an elevated VMA. If both VMA and metanephrines are tested, >98% of patients with pheochromocytomas will … View more
Assay limitations: Help
Drugs such as L-dopa, dopamine, epinephrine and norepinephrine are metabolized to HVA and VMA and will fictitiously elevate their levels in the urine. Therefore, the patient should not be on such drugs when collecting the urine.
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
Yes

Method used for proficiency testing: Help
Formal PT program

PT Provider: Help
American College of Medical Genetics / College of American Pathologists, ACMG/CAP

Description of PT method: Help
Gas chromatography/Mass spectrometry

CAP Testing Information Help
CAP/ACMG Biochemical Genetics; Biochemical genetics; BGL
Recommended fields not provided:
Test Confirmation, Citations to support assay limitations, Description of internal test validation method, Citations for Analytical validity
Regulatory Approval
FDA Review: Help
Not provided
Additional Information

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.