U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Myoepithelial tumor

MedGen UID:
10235
•Concept ID:
C0027070
•
Neoplastic Process
Synonyms: Myoepithelial Tumor; Myoepithelial Tumors; Myoepithelioma; Myoepitheliomas; Tumor, Myoepithelial; Tumors, Myoepithelial
SNOMED CT: Myoepithelioma (69291002); Myoepithelial tumor (69291002); Myoepithelial adenoma (69291002); Myoepithelioma (1295245001)
 
Monarch Initiative: MONDO:0002380

Definition

A benign or malignant tumor characterized by the presence of cells that show myoepithelial differentiation. Based on its morphologic features, it is classified as benign or malignant. A representative example of benign myoepithelioma is benign salivary gland myoepithelioma. Representative examples of malignant myoepithelioma or myoepithelial carcinoma are malignant breast myoepithelioma and salivary gland myoepithelial carcinoma. [from NCI]

Professional guidelines

PubMed

PLACE AND TECHNICS OF RADIATION THERAPY IN THE MANAGEMENT OF MALIGNANT TUMORS OF THE MAJOR SALIVARY GLANDS.
ALANIZ F, FLETCHER GH
Radiology 1965 Mar;84:412-9. doi: 10.1148/84.3.412. PMID: 14280711
SALIVARY GLAND TUMORS. THEIR EARLY DIAGNOSIS AND TREATMENT.
NELSON WR, DAVIS WM
Rocky Mt Med J 1964 May;61:27-32. PMID: 14153101
THE MANAGEMENT AND PROGNOSIS OF METASTATIC NEOPLASMS OF THE NECK WITH AN UNKNOWN PRIMARY.
FRANCE CJ, LUCAS R
Am J Surg 1963 Nov;106:835-9. doi: 10.1016/0002-9610(63)90411-2. PMID: 14078740

Recent clinical studies

Etiology

Cytology-histology correlation of myoepithelial tumors harboring EWSR1-POU5F1 fusions: A report of two cases.
Gelarden IA, Fu L, Yap KL, Richardson AI, Chou PM
Diagn Cytopathol 2022 Jun;50(6):E163-E169. Epub 2022 Feb 6 doi: 10.1002/dc.24941. PMID: 35128846
Myoepithelial and oral intracranial myxoid mesenchymal tumor-like neoplasms as diagnostic considerations of the ever-expanding extracranial myxocollagenous tumors harboring FET-CREB fusions.
Lee PH, Kao YC, Hsieh TH, Liao JB, Li CF, Lee JC, Chang YM, Chang CD, Huang SC, Chen TJ, Liu TT, Yu SC, Huang HY
Pathol Res Pract 2022 Jan;229:153700. Epub 2021 Nov 24 doi: 10.1016/j.prp.2021.153700. PMID: 34929603
Pulmonary Myoepithelial Tumors With Exuberant Reactive Pneumocytes: Proposed Reclassification of So-called Pneumocytic Adenomyoepithelioma.
Yuan L, Katabi N, Antonescu CR, Golden A, Travis WD, Rekhtman N
Am J Surg Pathol 2020 Jan;44(1):140-147. doi: 10.1097/PAS.0000000000001376. PMID: 31567188Free PMC Article
Newly Described Entities in Salivary Gland Pathology.
Skálová A, Gnepp DR, Lewis JS Jr, Hunt JL, Bishop JA, Hellquist H, Rinaldo A, Vander Poorten V, Ferlito A
Am J Surg Pathol 2017 Aug;41(8):e33-e47. doi: 10.1097/PAS.0000000000000883. PMID: 28614209
Myoepithelial tumor of soft tissue: histology and genetics of an evolving entity.
Thway K, Fisher C
Adv Anat Pathol 2014 Nov;21(6):411-9. doi: 10.1097/PAP.0000000000000039. PMID: 25299310

Diagnosis

A Case of Adenomyoepithelioma With a Pleomorphic Adenoma-Like Component of the Male Breast.
Harada J, Horiguchi SI, Ishiba T, Kubota H, Ichida M, Sakurai N, Arai H, Motoi T, Aruga T, Hishima T
Int J Surg Pathol 2021 Aug;29(5):538-542. Epub 2020 Dec 8 doi: 10.1177/1066896920978824. PMID: 33289419
Newly Described Entities in Salivary Gland Pathology.
Skálová A, Gnepp DR, Lewis JS Jr, Hunt JL, Bishop JA, Hellquist H, Rinaldo A, Vander Poorten V, Ferlito A
Am J Surg Pathol 2017 Aug;41(8):e33-e47. doi: 10.1097/PAS.0000000000000883. PMID: 28614209
Myoepithelial tumor of soft tissue and bone: A current perspective.
Verma A, Rekhi B
Histol Histopathol 2017 Sep;32(9):861-877. Epub 2017 Feb 1 doi: 10.14670/HH-11-879. PMID: 28145559
Myoepithelial tumor of soft tissue: histology and genetics of an evolving entity.
Thway K, Fisher C
Adv Anat Pathol 2014 Nov;21(6):411-9. doi: 10.1097/PAP.0000000000000039. PMID: 25299310
Bronchial epithelial-myoepithelial carcinoma.
Ru K, Srivastava A, Tischler AS
Arch Pathol Lab Med 2004 Jan;128(1):92-4. doi: 10.5858/2004-128-92-BEC. PMID: 14692803

Therapy

An intraosseous myoepithelial carcinoma with a EWSR1::PBX3 fusion.
Haglund C, Zemmler M, Tsagkozis P, Haglund de Flon F
Genes Chromosomes Cancer 2023 Oct;62(10):607-610. Epub 2023 May 2 doi: 10.1002/gcc.23148. PMID: 37129228
Anti-androgen for myoepithelial tumor: a potent therapy yet a potential misleader.
Hijab A, Taha T, Charas T, Bar-Sela G, Stein P, Agbarya A
Anticancer Drugs 2022 Jan 1;33(1):e747-e751. doi: 10.1097/CAD.0000000000001175. PMID: 34387605
Bone Sarcoma With EWSR1-NFATC2 Fusion: Sarcoma With Varied Morphology and Amplification of Fusion Gene Distinct From Ewing Sarcoma.
Yau DTW, Chan JKC, Bao S, Zheng Z, Lau GTC, Chan ACL
Int J Surg Pathol 2019 Aug;27(5):561-567. Epub 2019 Feb 3 doi: 10.1177/1066896919827093. PMID: 30714449
Non-rhabdoid pediatric SMARCB1-deficient tumors: overlap between chordomas and malignant rhabdoid tumors?
Renard C, Pissaloux D, Decouvelaere AV, Bourdeaut F, Ranchère D
Cancer Genet 2014 Sep;207(9):384-9. Epub 2014 May 23 doi: 10.1016/j.cancergen.2014.05.005. PMID: 25053104

Prognosis

Myoepithelial Tumors of Salivary Gland: A Clinicopathologic and Immunohistochemical Study of 15 Patients with MIB-1 Correlation.
Telugu RB, Gaikwad P, Baitule A, Michael RC, Mani T, Thomas M
Head Neck Pathol 2021 Jun;15(2):479-490. Epub 2020 Sep 21 doi: 10.1007/s12105-020-01225-0. PMID: 32959208Free PMC Article
Lipofibromatosis-Like Neural Tumor: A Case Report and Review of the Literature.
Crumbach L, Descotes F, Bringuier PP, Poulalhon N, Balme B, Juliet T, Lopez J, Harou O
Am J Dermatopathol 2020 Nov;42(11):881-884. doi: 10.1097/DAD.0000000000001734. PMID: 32618702
Newly Described Entities in Salivary Gland Pathology.
Skálová A, Gnepp DR, Lewis JS Jr, Hunt JL, Bishop JA, Hellquist H, Rinaldo A, Vander Poorten V, Ferlito A
Am J Surg Pathol 2017 Aug;41(8):e33-e47. doi: 10.1097/PAS.0000000000000883. PMID: 28614209
Myoepithelial tumor of soft tissue: histology and genetics of an evolving entity.
Thway K, Fisher C
Adv Anat Pathol 2014 Nov;21(6):411-9. doi: 10.1097/PAP.0000000000000039. PMID: 25299310
NEOPLASMS OF BRONCHUS COMMONLY DESIGNATED AS ADENOMAS.
MARKEL SF, ABELL MR, HAIGHT C, FRENCH AJ
Cancer 1964 May;17:590-608. doi: 10.1002/1097-0142(196405)17:5<590::aid-cncr2820170508>3.0.co;2-j. PMID: 14159808

Clinical prediction guides

GRM1 Immunohistochemistry Distinguishes Chondromyxoid Fibroma From its Histologic Mimics.
Toland AMS, Lam SW, Varma S, Wang A, Howitt BE, Kunder CA, Kerr DA, Szuhai K, Bovée JVMG, Charville GW
Am J Surg Pathol 2022 Oct 1;46(10):1407-1414. Epub 2022 Jun 1 doi: 10.1097/PAS.0000000000001921. PMID: 35650682Free PMC Article
Myoepithelial and oral intracranial myxoid mesenchymal tumor-like neoplasms as diagnostic considerations of the ever-expanding extracranial myxocollagenous tumors harboring FET-CREB fusions.
Lee PH, Kao YC, Hsieh TH, Liao JB, Li CF, Lee JC, Chang YM, Chang CD, Huang SC, Chen TJ, Liu TT, Yu SC, Huang HY
Pathol Res Pract 2022 Jan;229:153700. Epub 2021 Nov 24 doi: 10.1016/j.prp.2021.153700. PMID: 34929603
Myoepithelial tumor of soft tissue: histology and genetics of an evolving entity.
Thway K, Fisher C
Adv Anat Pathol 2014 Nov;21(6):411-9. doi: 10.1097/PAP.0000000000000039. PMID: 25299310
A HISTOCHEMICAL OBSERVATION OF BETA-GLUCURONIDASE IN ORAL NEOPLASMS.
OKA R, OKAMOTO Y, OHMACHI K, MORI M
Oral Surg Oral Med Oral Pathol 1964 May;17:628-34. doi: 10.1016/0030-4220(64)90369-x. PMID: 14131583
HISTOCHEMICAL OBSERVATIONS OF SUCCINIC, MALIC, AND LACTIC DEHYDROGENASE IN ORAL TUMORS.
MORI M, MIZUSHIMA T, OKA R, OKAMOTO Y, TAKITA Y
Oral Surg Oral Med Oral Pathol 1964 Mar;17:352-63. doi: 10.1016/0030-4220(64)90507-9. PMID: 14130238

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...