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Basal Cell Adenoma

MedGen UID:
104696
•Concept ID:
C0205646
•
Neoplastic Process
Synonyms: Adenoma, Basal Cell; Adenomas, Basal Cell; Basal Cell Adenomas
SNOMED CT: Basal cell adenoma (27230006)

Definition

A salivary gland benign epithelial neoplasm with a uniform, monomorphic appearance that is dominated by basal cells forming trabecular structures. It is rare and occurs mostly on the parotid gland. The average age of patients has been reported to be 58 years. Swelling is the most constant clinical finding. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBasal Cell Adenoma

Professional guidelines

PubMed

The differential diagnosis of parotid gland tumors with high-resolution ultrasound in otolaryngological practice.
Rzepakowska A, Osuch-Wójcikiewicz E, Sobol M, Cruz R, Sielska-Badurek E, Niemczyk K
Eur Arch Otorhinolaryngol 2017 Aug;274(8):3231-3240. Epub 2017 Jun 13 doi: 10.1007/s00405-017-4636-2. PMID: 28612315Free PMC Article
The congenital basal cell adenoma of salivary glands. Contribution to the differential diagnosis of congenital salivary gland tumours.
Seifert G, Donath K
Virchows Arch 1997 Apr;430(4):311-9. doi: 10.1007/BF01092754. PMID: 9134042
Classification and differential diagnosis of clear and basal cell tumors of the salivary glands.
Seifert G
Semin Diagn Pathol 1996 May;13(2):95-103. PMID: 8734415

Recent clinical studies

Etiology

Pitfalls in Salivary Gland Cytology.
Saoud C, Bailey GE, Graham A, Bonilla LM, Sanchez SI, Maleki Z
Acta Cytol 2024;68(3):194-205. Epub 2024 Feb 28 doi: 10.1159/000538069. PMID: 38417405
Basal cell adenoma and pleomorphic adenoma of the parotid gland: a single center experience.
Bianchini C, Brugali M, Migliorelli A, Corazzi V, Cammaroto G, Meccariello G, Stomeo F, Ciorba A, Pelucchi S
Minerva Surg 2023 Dec;78(6):626-632. Epub 2023 Aug 2 doi: 10.23736/S2724-5691.23.09876-3. PMID: 37530711
Basal cell adenoma: a case report.
Esteves AR, Dib LL, de Carvalho LV
J Oral Maxillofac Surg 1997 Nov;55(11):1323-5. doi: 10.1016/s0278-2391(97)90193-2. PMID: 9371128
Low grade basaloid adenocarcinoma of salivary gland in childhood--the so-called hybrid basal cell adenoma--adenoid cystic carcinoma.
Adkins GF
Pathology 1990 Oct;22(4):187-90. doi: 10.3109/00313029009086658. PMID: 1965332
The intraoral basal cell adenoma.
Pogrel MA
J Craniomaxillofac Surg 1987 Dec;15(6):372-5. doi: 10.1016/s1010-5182(87)80086-0. PMID: 3480902

Diagnosis

Basal cell adenoma of the parotid gland: A rare entity.
Ben Abdeljelil N, Masmoudi M, Thabet W, Bellalah A, Chebil E, Hasnaoui M, Mighri K
Ear Nose Throat J 2024 Apr;103(4):NP219-NP222. Epub 2021 Sep 29 doi: 10.1177/01455613211045524. PMID: 34587790
Basal Cell Adenoma and Basal Cell Adenocarcinoma.
Robinson RA
Surg Pathol Clin 2021 Mar;14(1):25-42. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.005. PMID: 33526221
Photoclinic Diagnosis: Basal cell adenocarcinoma.
Desai KM, Angadi PV, Kale AD, Hallikerimath S
Arch Iran Med 2019 Jan 1;22(1):57-58. PMID: 30821163
Basaloid/blue salivary gland tumors.
Seethala RR
Mod Pathol 2017 Jan;30(s1):S84-S95. doi: 10.1038/modpathol.2016.190. PMID: 28060371
Basal cell adenoma of the salivary glands.
Thawley SE, Ward SP, Ogura JH
Laryngoscope 1974 Oct;84(10):1756-66. doi: 10.1288/00005537-197410000-00010. PMID: 4371182

Therapy

Resection of benign tumours of the submandibular gland with harmonic scalpel-assisted minimally extracapsular dissection.
Hu Y, Zheng C, Cao R, Hong W, Zhang Z
J Int Med Res 2020 Jan;48(1):300060519892783. doi: 10.1177/0300060519892783. PMID: 31971033Free PMC Article
Basal cell adenoma and myoepithelioma of the parotid gland: patterns of enhancement at two-phase CT in comparison with Warthin tumor.
Lee JY, Kim HJ, Kim YK, Cha J, Kim ST
Diagn Interv Radiol 2019 Jul;25(4):285-290. doi: 10.5152/dir.2019.18337. PMID: 31120425Free PMC Article
Basal cell adenoma in the parapharyngeal space resected via trans-oral approach aided by endoscopy: Case series and a review of the literature.
Wu TT, Bao YY, Zhou SH, Wang QY, Shen LF
Medicine (Baltimore) 2018 Aug;97(34):e11837. doi: 10.1097/MD.0000000000011837. PMID: 30142775Free PMC Article
Basal cell adenoma of the parotid gland: characteristics of 2-phase helical computed tomography and magnetic resonance imaging.
Lee DK, Chung KW, Baek CH, Jeong HS, Ko YH, Son YI
J Comput Assist Tomogr 2005 Nov-Dec;29(6):884-8. doi: 10.1097/01.rct.0000183273.70422.c4. PMID: 16272868
Imprint cytology of metastatic sialoblastoma. A case report.
Huang R, Jaffer S
Acta Cytol 2003 Nov-Dec;47(6):1123-6. doi: 10.1159/000326662. PMID: 14674095

Prognosis

Basal Cell Adenoma and Basal Cell Adenocarcinoma: a 50-year Experience From a Single Institution.
Rito M, Esteves S, Fonseca I
Head Neck Pathol 2022 Dec;16(4):1157-1166. Epub 2022 Aug 10 doi: 10.1007/s12105-022-01484-z. PMID: 35947346Free PMC Article
Basal Cell Adenoma and Basal Cell Adenocarcinoma.
Robinson RA
Surg Pathol Clin 2021 Mar;14(1):25-42. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.005. PMID: 33526221
Basal cell adenoma: a case report.
Esteves AR, Dib LL, de Carvalho LV
J Oral Maxillofac Surg 1997 Nov;55(11):1323-5. doi: 10.1016/s0278-2391(97)90193-2. PMID: 9371128
Low grade basaloid adenocarcinoma of salivary gland in childhood--the so-called hybrid basal cell adenoma--adenoid cystic carcinoma.
Adkins GF
Pathology 1990 Oct;22(4):187-90. doi: 10.3109/00313029009086658. PMID: 1965332
The intraoral basal cell adenoma.
Pogrel MA
J Craniomaxillofac Surg 1987 Dec;15(6):372-5. doi: 10.1016/s1010-5182(87)80086-0. PMID: 3480902

Clinical prediction guides

Pitfalls in Salivary Gland Cytology.
Saoud C, Bailey GE, Graham A, Bonilla LM, Sanchez SI, Maleki Z
Acta Cytol 2024;68(3):194-205. Epub 2024 Feb 28 doi: 10.1159/000538069. PMID: 38417405
TGFβ-induced EN1 promotes tumor budding of adenoid cystic carcinoma in patient-derived organoid model.
Hui Z, Wang B, Liu Z, Wei J, Gan J, Landstrom M, Mu Y, Zang G
Int J Cancer 2024 May 15;154(10):1814-1827. Epub 2024 Jan 28 doi: 10.1002/ijc.34856. PMID: 38282121
TRPS1 immunohistochemical expression in salivary gland tumors: A pilot study.
Tjendra Y, Kerr DA, Gomez-Fernandez C, Velez Torres JM
Am J Clin Pathol 2023 Dec 1;160(6):633-639. doi: 10.1093/ajcp/aqad100. PMID: 37565763
Basal cell adenoma and pleomorphic adenoma of the parotid gland: a single center experience.
Bianchini C, Brugali M, Migliorelli A, Corazzi V, Cammaroto G, Meccariello G, Stomeo F, Ciorba A, Pelucchi S
Minerva Surg 2023 Dec;78(6):626-632. Epub 2023 Aug 2 doi: 10.23736/S2724-5691.23.09876-3. PMID: 37530711
Basal cell adenoma of the parotid gland: clinical and pathological findings in 29 cases.
Lu J, Zhang W, Wang Z, Jia H, Ma Y, Wu H, Xiang M
Int J Clin Exp Pathol 2015;8(3):2899-908. Epub 2015 Mar 1 PMID: 26045798Free PMC Article

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