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Pineoblastoma

MedGen UID:
104745
Concept ID:
C0205898
Neoplastic Process
Synonym: Pineoblastomas
SNOMED CT: Pineoblastoma (767448007); Pineoblastoma (31671006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
HPO: HP:0030408
Monarch Initiative: MONDO:0016722
Orphanet: ORPHA251909

Definition

Pineoblastoma is a rare primitive neuroectodermal tumor (PNET) arising in the pineal gland. Pineoblastomas are classified as a WHO grade IV tumor and comprise one-fourth to one-half of pineal parenchymal tumors. Pineoblastoma is a highly cellular tumor originating in the pineal gland and containing small, poorly differentiated cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPineoblastoma
Follow this link to review classifications for Pineoblastoma in Orphanet.

Professional guidelines

PubMed

Liu APY, Li BK, Vasiljevic A, Dewan MC, Tamrazi B, Ertl-Wagner B, Hansford JR, Pfaff E, Mynarek M, Ng HK, Tsang DS, Gottardo NG, Gajjar A, Bouffet E, Dufour C, Pizer B, Schiff D, Jenkinson MD, Lombardi G, Wen PY, van den Bent MJ, Huang A
Neuro Oncol 2024 Dec 5;26(12):2159-2173. doi: 10.1093/neuonc/noae128. PMID: 39073785Free PMC Article
Sin-Chan P, Li BK, Ho B, Fonseca A, Huang A
Curr Oncol Rep 2018 Jul 11;20(9):69. doi: 10.1007/s11912-018-0717-7. PMID: 29995179
Tate MC, Rutkowski MJ, Parsa AT
Neurosurg Clin N Am 2011 Jul;22(3):409-12, ix. Epub 2011 Jun 16 doi: 10.1016/j.nec.2011.05.001. PMID: 21801990

Recent clinical studies

Etiology

Liu APY, Li BK, Vasiljevic A, Dewan MC, Tamrazi B, Ertl-Wagner B, Hansford JR, Pfaff E, Mynarek M, Ng HK, Tsang DS, Gottardo NG, Gajjar A, Bouffet E, Dufour C, Pizer B, Schiff D, Jenkinson MD, Lombardi G, Wen PY, van den Bent MJ, Huang A
Neuro Oncol 2024 Dec 5;26(12):2159-2173. doi: 10.1093/neuonc/noae128. PMID: 39073785Free PMC Article
Li BK, Al-Karmi S, Huang A, Bouffet E
Expert Rev Mol Diagn 2020 Mar;20(3):293-303. Epub 2020 Jan 15 doi: 10.1080/14737159.2020.1714439. PMID: 31917601
Hořínová V, Drábová K, Nosková H, Bajčiová V, Šoukalová J, Černá L, Hůrková V, Slabý O, Štěrba J
Klin Onkol 2019 Summer;32(Supplementum2):123-127. doi: 10.14735/amko2019S123. PMID: 31409088
Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557Free PMC Article
Li MH, Bouffet E, Hawkins CE, Squire JA, Huang A
Neurosurg Focus 2005 Nov 15;19(5):E3. doi: 10.3171/foc.2005.19.5.4. PMID: 16398467

Diagnosis

Liu APY, Li BK, Vasiljevic A, Dewan MC, Tamrazi B, Ertl-Wagner B, Hansford JR, Pfaff E, Mynarek M, Ng HK, Tsang DS, Gottardo NG, Gajjar A, Bouffet E, Dufour C, Pizer B, Schiff D, Jenkinson MD, Lombardi G, Wen PY, van den Bent MJ, Huang A
Neuro Oncol 2024 Dec 5;26(12):2159-2173. doi: 10.1093/neuonc/noae128. PMID: 39073785Free PMC Article
Meredith DM
Adv Anat Pathol 2020 May;27(3):206-219. doi: 10.1097/PAP.0000000000000225. PMID: 30720470
Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557Free PMC Article
Han SJ, Clark AJ, Ivan ME, Parsa AT, Perry A
Neurosurg Clin N Am 2011 Jul;22(3):335-40, vii. Epub 2011 Jun 16 doi: 10.1016/j.nec.2011.05.006. PMID: 21801981
Li MH, Bouffet E, Hawkins CE, Squire JA, Huang A
Neurosurg Focus 2005 Nov 15;19(5):E3. doi: 10.3171/foc.2005.19.5.4. PMID: 16398467

Therapy

Zhang R, Li J, Hui X, Zhang S
Neurology 2024 Nov 12;103(9):e209937. Epub 2024 Oct 4 doi: 10.1212/WNL.0000000000209937. PMID: 39365972
Rosenberg T, Cooney T
Pediatr Neurosurg 2023;58(5):299-306. Epub 2023 May 26 doi: 10.1159/000531256. PMID: 37245504
Liu APY, Li BK, Pfaff E, Gudenas B, Vasiljevic A, Orr BA, Dufour C, Snuderl M, Karajannis MA, Rosenblum MK, Hwang EI, Ng HK, Hansford JR, Szathmari A, Faure-Conter C, Merchant TE, Levine M, Bouvier N, von Hoff K, Mynarek M, Rutkowski S, Sahm F, Kool M, Hawkins C, Onar-Thomas A, Robinson GW, Gajjar A, Pfister SM, Bouffet E, Northcott PA, Jones DTW, Huang A
Acta Neuropathol 2021 May;141(5):771-785. Epub 2021 Feb 22 doi: 10.1007/s00401-021-02284-5. PMID: 33619588Free PMC Article
Hleyhel M, Goujon S, Sibiude J, Tubiana R, Dollfus C, Faye A, Mandelbrot L, Clavel J, Warszawski J, Blanche S; ANRS French Perinatal Cohort study Group
Environ Mol Mutagen 2019 Jun;60(5):404-409. Epub 2017 Dec 5 doi: 10.1002/em.22162. PMID: 29206312
Antoneli CB, Ribeiro Kde C, Sakamoto LH, Chojniak MM, Novaes PE, Arias VE
Pediatr Blood Cancer 2007 Mar;48(3):306-10. doi: 10.1002/pbc.20793. PMID: 16572402

Prognosis

Cambruzzi E, Medeiros MS, da Silva JNAM, Nascimento GBC, Zandoná NB, Kus WP
Childs Nerv Syst 2022 Aug;38(8):1625-1629. Epub 2022 Jan 10 doi: 10.1007/s00381-021-05441-z. PMID: 35006340
González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article
Cai C
Semin Diagn Pathol 2021 May;38(3):167-174. Epub 2021 Mar 15 doi: 10.1053/j.semdp.2021.03.003. PMID: 33762087
Tate MC, Rutkowski MJ, Parsa AT
Neurosurg Clin N Am 2011 Jul;22(3):409-12, ix. Epub 2011 Jun 16 doi: 10.1016/j.nec.2011.05.001. PMID: 21801990
Antoneli CB, Ribeiro Kde C, Sakamoto LH, Chojniak MM, Novaes PE, Arias VE
Pediatr Blood Cancer 2007 Mar;48(3):306-10. doi: 10.1002/pbc.20793. PMID: 16572402

Clinical prediction guides

Hořínová V, Drábová K, Nosková H, Bajčiová V, Šoukalová J, Černá L, Hůrková V, Slabý O, Štěrba J
Klin Onkol 2019 Summer;32(Supplementum2):123-127. doi: 10.14735/amko2019S123. PMID: 31409088
Dimaras H, Corson TW
J Neurosci Res 2019 Jan;97(1):29-44. Epub 2018 Jan 3 doi: 10.1002/jnr.24213. PMID: 29314142Free PMC Article
Raghuram CP, Moreno L, Zacharoulis S
J Neurooncol 2012 Feb;106(3):441-7. Epub 2011 Aug 18 doi: 10.1007/s11060-011-0690-6. PMID: 21850536
Brown AE, Leibundgut K, Niggli FK, Betts DR
Cancer Genet Cytogenet 2006 Oct 15;170(2):175-9. doi: 10.1016/j.cancergencyto.2006.06.009. PMID: 17011992
Bader JL, Meadows AT, Zimmerman LE, Rorke LB, Voute PA, Champion LA, Miller RW
Cancer Genet Cytogenet 1982 Mar;5(3):203-13. doi: 10.1016/0165-4608(82)90026-7. PMID: 7066879

Recent systematic reviews

Wilson JS, Main C, Thorp N, Taylor RE, Majothi S, Kearns PR, English M, Dandapani M, Phillips R, Wheatley K, Pizer B
J Neurooncol 2024 Mar;167(1):1-34. Epub 2024 Jan 31 doi: 10.1007/s11060-023-04510-4. PMID: 38294638Free PMC Article
Gagliardi F, De Domenico P, Garbin E, Snider S, Mortini P
J Pineal Res 2023 Dec;75(4):e12910. Epub 2023 Sep 13 doi: 10.1111/jpi.12910. PMID: 37705383
Raghuram CP, Moreno L, Zacharoulis S
J Neurooncol 2012 Feb;106(3):441-7. Epub 2011 Aug 18 doi: 10.1007/s11060-011-0690-6. PMID: 21850536

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