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Abnormal syntax

MedGen UID:
1054793
•Concept ID:
CN378238
•
Finding
HPO: HP:0025782

Definition

Persistent abnormalities in sentence structure exceeding that of the context and background culture of the person. [from HPO]

Professional guidelines

PubMed

Spoken language outcome measures for treatment studies in Down syndrome: feasibility, practice effects, test-retest reliability, and construct validity of variables generated from expressive language sampling.
Thurman AJ, Edgin JO, Sherman SL, Sterling A, McDuffie A, Berry-Kravis E, Hamilton D, Abbeduto L
J Neurodev Disord 2021 Apr 8;13(1):13. doi: 10.1186/s11689-021-09361-6. PMID: 33827417Free PMC Article
Expressive language sampling as a source of outcome measures for treatment studies in fragile X syndrome: feasibility, practice effects, test-retest reliability, and construct validity.
Abbeduto L, Berry-Kravis E, Sterling A, Sherman S, Edgin JO, McDuffie A, Hoffmann A, Hamilton D, Nelson M, Aschkenasy J, Thurman AJ
J Neurodev Disord 2020 Mar 24;12(1):10. doi: 10.1186/s11689-020-09313-6. PMID: 32204695Free PMC Article
Speech and language in a genotyped cohort of individuals with Kabuki syndrome.
Morgan AT, Mei C, Da Costa A, Fifer J, Lederer D, Benoit V, McMillin MJ, Buckingham KJ, Bamshad MJ, Pope K, White SM
Am J Med Genet A 2015 Jul;167(7):1483-92. Epub 2015 Mar 8 doi: 10.1002/ajmg.a.37026. PMID: 25755104

Recent clinical studies

Etiology

Morphosyntactic abilities in young children with Down syndrome: Evidence from the Greek language.
Katsarou D, Andreou G
Int J Lang Commun Disord 2022 Sep;57(5):937-947. Epub 2022 Jun 11 doi: 10.1111/1460-6984.12730. PMID: 35689466
Peer Victimization and Communication Skills in Adolescents with Down Syndrome: Preliminary Findings.
Reardanz J, Conners FA, McDonald KL, Singh N
J Autism Dev Disord 2020 Jan;50(1):349-355. doi: 10.1007/s10803-019-04238-z. PMID: 31571067
Sleep Disturbance and Expressive Language Development in Preschool-Age Children With Down Syndrome.
Edgin JO, Tooley U, Demara B, Nyhuis C, Anand P, Spanò G
Child Dev 2015 Nov-Dec;86(6):1984-98. Epub 2015 Oct 5 doi: 10.1111/cdev.12443. PMID: 26435268Free PMC Article
Abnormal dynamics of language in schizophrenia.
Stephane M, Kuskowski M, Gundel J
Psychiatry Res 2014 May 30;216(3):320-4. Epub 2014 Feb 28 doi: 10.1016/j.psychres.2014.02.027. PMID: 24629711
Update on the language disorders of individuals on the autistic spectrum.
Rapin I, Dunn M
Brain Dev 2003 Apr;25(3):166-72. doi: 10.1016/s0387-7604(02)00191-2. PMID: 12689694

Diagnosis

Morphosyntactic abilities in young children with Down syndrome: Evidence from the Greek language.
Katsarou D, Andreou G
Int J Lang Commun Disord 2022 Sep;57(5):937-947. Epub 2022 Jun 11 doi: 10.1111/1460-6984.12730. PMID: 35689466
Language characterization in 16p11.2 deletion and duplication syndromes.
Kim SH, Green-Snyder L, Lord C, Bishop S, Steinman KJ, Bernier R, Hanson E, Goin-Kochel RP, Chung WK
Am J Med Genet B Neuropsychiatr Genet 2020 Sep;183(6):380-391. Epub 2020 Jul 11 doi: 10.1002/ajmg.b.32809. PMID: 32652891Free PMC Article
Does the Development of Syntax Comprehension Show a Premature Asymptote Among Persons With Down Syndrome? A Cross-Sectional Analysis.
Facon B, Magis D
Am J Intellect Dev Disabil 2019 Mar;124(2):131-144. doi: 10.1352/1944-7558-124.2.131. PMID: 30835529
Cognitive, environmental, and linguistic predictors of syntax in fragile X syndrome and Down syndrome.
Estigarribia B, Martin GE, Roberts JE
J Speech Lang Hear Res 2012 Dec;55(6):1600-12. Epub 2012 Apr 3 doi: 10.1044/1092-4388(2012/10-0153). PMID: 22473836Free PMC Article
Language and communication development in Down syndrome.
Roberts JE, Price J, Malkin C
Ment Retard Dev Disabil Res Rev 2007;13(1):26-35. doi: 10.1002/mrdd.20136. PMID: 17326116

Therapy

Discrepancy between fractional flow reserve and instantaneous wave-free ratio: Clinical and angiographic characteristics.
Lee JM, Shin ES, Nam CW, Doh JH, Hwang D, Park J, Kim KJ, Zhang J, Koo BK
Int J Cardiol 2017 Oct 15;245:63-68. Epub 2017 Aug 2 doi: 10.1016/j.ijcard.2017.07.099. PMID: 28789845
Effect of coronary dominance on 2-year outcomes after percutaneous coronary intervention in patients with acute coronary syndrome.
He C, Ma YL, Wang CS, Song Y, Tang XF, Zhao XY, Gao RL, Yang YJ, Xu B, Yuan JQ
Catheter Cardiovasc Interv 2017 Mar;89(S1):549-554. doi: 10.1002/ccd.26978. PMID: 28318135
Variable disruption of a syntactic processing network in primary progressive aphasia.
Wilson SM, DeMarco AT, Henry ML, Gesierich B, Babiak M, Miller BL, Gorno-Tempini ML
Brain 2016 Nov 1;139(11):2994-3006. doi: 10.1093/brain/aww218. PMID: 27554388Free PMC Article
Incidence, correlates, and significance of abnormal cardiac enzyme rises in patients treated with surgical or percutaneous based revascularisation: a substudy from the Synergy between Percutaneous Coronary Interventions with Taxus and Cardiac Surgery (SYNTAX) Trial.
Farooq V, Serruys PW, Vranckx P, Bourantas CV, Girasis C, Holmes DR, Kappetein AP, Mack M, Feldman T, Morice MC, Colombo A, Morel MA, de Vries T, Dawkins KD, Mohr FW, James S, Ståhle E
Int J Cardiol 2013 Oct 15;168(6):5287-92. Epub 2013 Aug 14 doi: 10.1016/j.ijcard.2013.08.013. PMID: 23993326
Can individuals with Down syndrome improve their grammar?
Sepúlveda EM, López-Villaseñor ML, Heinze EG
Int J Lang Commun Disord 2013 May-Jun;48(3):343-9. Epub 2013 Feb 8 doi: 10.1111/1460-6984.12002. PMID: 23650890

Prognosis

The Predictive Model of Oral Squamous Cell Survival Carcinoma: A Methodology of Validation.
Ahmad WMAW, Yaqoob MA, Noor NFM, Ghazali FMM, Rahman NA, Tang L, Aleng NA, Alam MK
Biomed Res Int 2021;2021:5436894. Epub 2021 Nov 25 doi: 10.1155/2021/5436894. PMID: 34904115Free PMC Article
Theory of Mind in children and adolescents with Down syndrome.
Neitzel I, Penke M
Res Dev Disabil 2021 Jun;113:103945. Epub 2021 Apr 14 doi: 10.1016/j.ridd.2021.103945. PMID: 33862539
Linguistic Characteristics of Mandarin-Speaking Huntington's Disease Patients.
Dong LL, Liu CY, Mao CH, Chu SS, Li J, Huang XY, Gao J
Chin Med Sci J 2020 Sep 30;35(3):207-214. doi: 10.24920/003669. PMID: 32972498
Cognitive, environmental, and linguistic predictors of syntax in fragile X syndrome and Down syndrome.
Estigarribia B, Martin GE, Roberts JE
J Speech Lang Hear Res 2012 Dec;55(6):1600-12. Epub 2012 Apr 3 doi: 10.1044/1092-4388(2012/10-0153). PMID: 22473836Free PMC Article
Language and thinking in psychosis. Is there an input abnormality?
Grove WM, Andreasen NC
Arch Gen Psychiatry 1985 Jan;42(1):26-32. doi: 10.1001/archpsyc.1985.01790240028003. PMID: 3966850

Clinical prediction guides

Speech and language in children with Klinefelter syndrome.
St John M, Ponchard C, van Reyk O, Mei C, Pigdon L, Amor DJ, Morgan AT
J Commun Disord 2019 Mar-Apr;78:84-96. Epub 2019 Feb 12 doi: 10.1016/j.jcomdis.2019.02.003. PMID: 30822601
Discrepancy between fractional flow reserve and instantaneous wave-free ratio: Clinical and angiographic characteristics.
Lee JM, Shin ES, Nam CW, Doh JH, Hwang D, Park J, Kim KJ, Zhang J, Koo BK
Int J Cardiol 2017 Oct 15;245:63-68. Epub 2017 Aug 2 doi: 10.1016/j.ijcard.2017.07.099. PMID: 28789845
Abnormal dynamics of language in schizophrenia.
Stephane M, Kuskowski M, Gundel J
Psychiatry Res 2014 May 30;216(3):320-4. Epub 2014 Feb 28 doi: 10.1016/j.psychres.2014.02.027. PMID: 24629711
Cognitive, environmental, and linguistic predictors of syntax in fragile X syndrome and Down syndrome.
Estigarribia B, Martin GE, Roberts JE
J Speech Lang Hear Res 2012 Dec;55(6):1600-12. Epub 2012 Apr 3 doi: 10.1044/1092-4388(2012/10-0153). PMID: 22473836Free PMC Article
Update on the language disorders of individuals on the autistic spectrum.
Rapin I, Dunn M
Brain Dev 2003 Apr;25(3):166-72. doi: 10.1016/s0387-7604(02)00191-2. PMID: 12689694

Recent systematic reviews

Components of IGF-axis in growth disorders: a systematic review and patent landscape report.
Singh A, Pajni K, Panigrahi I, Dhoat N, Senapati S, Khetarpal P
Endocrine 2022 Jun;76(3):509-525. Epub 2022 May 6 doi: 10.1007/s12020-022-03063-2. PMID: 35523998
Language in childhood epilepsy: A systematic review and meta-analysis.
Bailey K, Im-Bolter N
Epilepsy Behav 2021 Jan;114(Pt A):107621. Epub 2020 Nov 27 doi: 10.1016/j.yebeh.2020.107621. PMID: 33257294
The long-term structural effect of orthoses for pediatric flexible flat foot: A systematic review.
Choi JY, Hong WH, Suh JS, Han JH, Lee DJ, Lee YJ
Foot Ankle Surg 2020 Feb;26(2):181-188. Epub 2019 Feb 1 doi: 10.1016/j.fas.2019.01.007. PMID: 30765257

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