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Abnormality of mental function

MedGen UID:
868938
Concept ID:
C4023352
Mental or Behavioral Dysfunction
Synonym: Abnormality of higher mental function
 
HPO: HP:0011446

Definition

Cognitive, psychiatric, or memory anomaly. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of mental function

Professional guidelines

PubMed

Salcedo-Arellano MJ, Hagerman RJ, Martínez-Cerdeño V
Gac Med Mex 2020;156(1):60-66. doi: 10.24875/GMM.19005275. PMID: 32026885
Arvanitakis Z, Shah RC, Bennett DA
JAMA 2019 Oct 22;322(16):1589-1599. doi: 10.1001/jama.2019.4782. PMID: 31638686Free PMC Article
Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F
JAMA Neurol 2018 Sep 1;75(9):1132-1141. doi: 10.1001/jamaneurol.2018.1264. PMID: 29868890Free PMC Article

Recent clinical studies

Etiology

Wang YR, Xu NX, Wang J, Wang XM
World J Pediatr 2019 Dec;15(6):528-535. Epub 2019 Oct 5 doi: 10.1007/s12519-019-00309-4. PMID: 31587141
Priolo M, Schanze D, Tatton-Brown K, Mulder PA, Tenorio J, Kooblall K, Acero IH, Alkuraya FS, Arias P, Bernardini L, Bijlsma EK, Cole T, Coubes C, Dapia I, Davies S, Di Donato N, Elcioglu NH, Fahrner JA, Foster A, González NG, Huber I, Iascone M, Kaiser AS, Kamath A, Liebelt J, Lynch SA, Maas SM, Mammì C, Mathijssen IB, McKee S, Menke LA, Mirzaa GM, Montgomery T, Neubauer D, Neumann TE, Pintomalli L, Pisanti MA, Plomp AS, Price S, Salter C, Santos-Simarro F, Sarda P, Segovia M, Shaw-Smith C, Smithson S, Suri M, Valdez RM, Van Haeringen A, Van Hagen JM, Zollino M, Lapunzina P, Thakker RV, Zenker M, Hennekam RC
Hum Mutat 2018 Sep;39(9):1226-1237. Epub 2018 Jun 25 doi: 10.1002/humu.23563. PMID: 29897170Free PMC Article
Mazurek D, Wyka J
Rocz Panstw Zakl Hig 2015;66(3):189-94. PMID: 26400113
Grieco J, Pulsifer M, Seligsohn K, Skotko B, Schwartz A
Am J Med Genet C Semin Med Genet 2015 Jun;169(2):135-49. Epub 2015 May 18 doi: 10.1002/ajmg.c.31439. PMID: 25989505
Ryan-Harshman M, Aldoori W
Can Fam Physician 2008 Apr;54(4):536-41. PMID: 18411381Free PMC Article

Diagnosis

Sánchez-Romero M, Tlaxcala-Castillo L, Pichardo-Rojas PS, Valencia-Melo MA, Paz-López ÁA, Sánchez-Sagastegui F, Wegman-Ostrosky T; International Sacral Agenesis/Caudal Regression Association
Pediatr Neurol 2025 Feb;163:27-34. Epub 2024 Nov 5 doi: 10.1016/j.pediatrneurol.2024.10.020. PMID: 39642685
Priolo M, Schanze D, Tatton-Brown K, Mulder PA, Tenorio J, Kooblall K, Acero IH, Alkuraya FS, Arias P, Bernardini L, Bijlsma EK, Cole T, Coubes C, Dapia I, Davies S, Di Donato N, Elcioglu NH, Fahrner JA, Foster A, González NG, Huber I, Iascone M, Kaiser AS, Kamath A, Liebelt J, Lynch SA, Maas SM, Mammì C, Mathijssen IB, McKee S, Menke LA, Mirzaa GM, Montgomery T, Neubauer D, Neumann TE, Pintomalli L, Pisanti MA, Plomp AS, Price S, Salter C, Santos-Simarro F, Sarda P, Segovia M, Shaw-Smith C, Smithson S, Suri M, Valdez RM, Van Haeringen A, Van Hagen JM, Zollino M, Lapunzina P, Thakker RV, Zenker M, Hennekam RC
Hum Mutat 2018 Sep;39(9):1226-1237. Epub 2018 Jun 25 doi: 10.1002/humu.23563. PMID: 29897170Free PMC Article
Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2010 Sep 29;5:25. doi: 10.1186/1750-1172-5-25. PMID: 20920258Free PMC Article
Powell CM, Michaelis RC
J Med Genet 1999 Feb;36(2):89-93. PMID: 10051003Free PMC Article
Silverman D, Masland WS, Rodin EA
Prog Neurol Psychiatry 1968;23:303-37. PMID: 4305965

Therapy

Butler G, Srirangalingam U, Faithfull J, Sangster P, Senniappan S, Mitchell R
Arch Dis Child 2023 Mar;108(3):166-171. Epub 2022 Aug 10 doi: 10.1136/archdischild-2020-320831. PMID: 35948402Free PMC Article
Fornaro M, Maritan E, Ferranti R, Zaninotto L, Miola A, Anastasia A, Murru A, Solé E, Stubbs B, Carvalho AF, Serretti A, Vieta E, Fusar-Poli P, McGuire P, Young AH, Dazzan P, Vigod SN, Correll CU, Solmi M
Am J Psychiatry 2020 Jan 1;177(1):76-92. Epub 2019 Oct 18 doi: 10.1176/appi.ajp.2019.19030228. PMID: 31623458
Ryan-Harshman M, Aldoori W
Can Fam Physician 2008 Apr;54(4):536-41. PMID: 18411381Free PMC Article
Wiebe E, Wiebe A
Can Fam Physician 1994 Feb;40:290-5. PMID: 8130676Free PMC Article
Jones RT
Annu Rev Med 1983;34:247-58. doi: 10.1146/annurev.me.34.020183.001335. PMID: 6305257

Prognosis

Sánchez-Romero M, Tlaxcala-Castillo L, Pichardo-Rojas PS, Valencia-Melo MA, Paz-López ÁA, Sánchez-Sagastegui F, Wegman-Ostrosky T; International Sacral Agenesis/Caudal Regression Association
Pediatr Neurol 2025 Feb;163:27-34. Epub 2024 Nov 5 doi: 10.1016/j.pediatrneurol.2024.10.020. PMID: 39642685
Farmer DL, Thom EA, Brock JW 3rd, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Gupta N, Adzick NS; Management of Myelomeningocele Study Investigators
Am J Obstet Gynecol 2018 Feb;218(2):256.e1-256.e13. Epub 2017 Dec 12 doi: 10.1016/j.ajog.2017.12.001. PMID: 29246577Free PMC Article
Hanly JG, O'Keeffe AG, Su L, Urowitz MB, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Clarke AE, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Fortin P, Gladman DD, Sanchez-Guerrero J, Petri M, Bruce IN, Dooley MA, Ramsey-Goldman R, Aranow C, Alarcón GS, Fessler BJ, Steinsson K, Nived O, Sturfelt GK, Manzi S, Khamashta MA, van Vollenhoven RF, Zoma AA, Ramos-Casals M, Ruiz-Irastorza G, Lim SS, Stoll T, Inanc M, Kalunian KC, Kamen DL, Maddison P, Peschken CA, Jacobsen S, Askanase A, Theriault C, Thompson K, Farewell V
Rheumatology (Oxford) 2016 Feb;55(2):252-62. Epub 2015 Sep 5 doi: 10.1093/rheumatology/kev311. PMID: 26342222Free PMC Article
Adzick NS, Thom EA, Spong CY, Brock JW 3rd, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Dabrowiak ME, Sutton LN, Gupta N, Tulipan NB, D'Alton ME, Farmer DL; MOMS Investigators
N Engl J Med 2011 Mar 17;364(11):993-1004. Epub 2011 Feb 9 doi: 10.1056/NEJMoa1014379. PMID: 21306277Free PMC Article
Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2010 Sep 29;5:25. doi: 10.1186/1750-1172-5-25. PMID: 20920258Free PMC Article

Clinical prediction guides

Compston A
Brain 2019 Aug 1;142(8):2538-2543. doi: 10.1093/brain/awz200. PMID: 31292617
de Koning TJ
J Inherit Metab Dis 2017 Jul;40(4):609-620. Epub 2017 Jun 26 doi: 10.1007/s10545-017-0063-1. PMID: 28653176Free PMC Article
Malak R, Kotwicka M, Krawczyk-Wasielewska A, Mojs E, Samborski W
Ann Agric Environ Med 2013;20(4):803-6. PMID: 24364457
Rosser T
Arch Neurol 2003 Oct;60(10):1471-3. doi: 10.1001/archneur.60.10.1471. PMID: 14568821
Haaf T, Hofmann R, Schmid M
Am J Med Genet 1991 Sep 15;40(4):444-6. doi: 10.1002/ajmg.1320400413. PMID: 1746609

Recent systematic reviews

Antoniou G, Lambourg E, Steele JD, Colvin LA
Br J Anaesth 2023 Jun;130(6):729-746. Epub 2023 Apr 21 doi: 10.1016/j.bja.2023.03.008. PMID: 37087334Free PMC Article
Boot E, Óskarsdóttir S, Loo JCY, Crowley TB, Orchanian-Cheff A, Andrade DM, Arganbright JM, Castelein RM, Cserti-Gazdewich C, de Reuver S, Fiksinski AM, Klingberg G, Lang AE, Mascarenhas MR, Moss EM, Nowakowska BA, Oechslin E, Palmer L, Repetto GM, Reyes NGD, Schneider M, Silversides C, Sullivan KE, Swillen A, van Amelsvoort TAMJ, Van Batavia JP, Vingerhoets C, McDonald-McGinn DM, Bassett AS
Genet Med 2023 Mar;25(3):100344. Epub 2023 Feb 2 doi: 10.1016/j.gim.2022.11.012. PMID: 36729052
Thwaites PA, Gibson PR, Burgell RE
J Gastroenterol Hepatol 2022 Sep;37(9):1693-1709. Epub 2022 Jul 20 doi: 10.1111/jgh.15927. PMID: 35750466Free PMC Article
Fornaro M, Maritan E, Ferranti R, Zaninotto L, Miola A, Anastasia A, Murru A, Solé E, Stubbs B, Carvalho AF, Serretti A, Vieta E, Fusar-Poli P, McGuire P, Young AH, Dazzan P, Vigod SN, Correll CU, Solmi M
Am J Psychiatry 2020 Jan 1;177(1):76-92. Epub 2019 Oct 18 doi: 10.1176/appi.ajp.2019.19030228. PMID: 31623458
Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, Fraser GL
Crit Care 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1. PMID: 29137682Free PMC Article

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