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Larynx squamous papilloma

MedGen UID:
116099
•Concept ID:
C0240164
•
Neoplastic Process
Synonyms: Laryngeal Papilloma; laryngeal papilloma; Laryngeal Squamous Cell Papilloma; Laryngeal Squamous Papilloma; Larynx Papilloma; larynx papilloma; larynx squamous papilloma; Papilloma of Larynx; papilloma of larynx; Papilloma of the Larynx; papilloma of the larynx; Squamous Papilloma of Larynx; squamous papilloma of larynx; Squamous Papilloma of the Larynx; squamous papilloma of the larynx
 
Monarch Initiative: MONDO:0000935

Definition

A benign exophytic neoplasm that arises from the larynx, usually the true vocal cords. It is related to human papillomavirus infection and may arise as a single or multiple lesions. It is characterized by the presence of a connective tissue core covered by stratified squamous epithelium. Hoarseness is the presenting symptom. Transformation to carcinoma is rare. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLarynx squamous papilloma

Professional guidelines

PubMed

Cancer of unknown primary in the head and neck: Diagnosis and treatment.
Ota I, Kitahara T
Auris Nasus Larynx 2021 Feb;48(1):23-31. Epub 2020 Sep 1 doi: 10.1016/j.anl.2020.08.014. PMID: 32888761
Recurrent respiratory papillomatosis of the larynx: current diagnosis and treatment.
Derkay CS, Darrow DH
Otolaryngol Clin North Am 2000 Oct;33(5):1127-42. doi: 10.1016/s0030-6665(05)70270-x. PMID: 10984775
Treatment of papilloma of the larynx.
CAPPS FC
Ann Otol Rhinol Laryngol 1957 Dec;66(4):926-38. doi: 10.1177/000348945706600403. PMID: 13498572

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

Recent clinical studies

Etiology

Results of CO2 laser surgery in laryngeal papillomatosis.
Solarz P, Mackiewicz-Nartowicz H, Sinkiewicz A, Burduk P
Oral Oncol 2024 Nov;158:107004. Epub 2024 Aug 19 doi: 10.1016/j.oraloncology.2024.107004. PMID: 39163742
Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
Bilateral Vocal Fold Granuloma and Anterior Glottic Web After Papilloma Excision.
Ostrander BT, Yu V, Vahabzadeh-Hagh A
Ear Nose Throat J 2023 Aug;102(8):NP408-NP409. Epub 2021 May 18 doi: 10.1177/01455613211012112. PMID: 34006147
Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments.
Solomon B, Young RJ, Rischin D
Semin Cancer Biol 2018 Oct;52(Pt 2):228-240. Epub 2018 Jan 31 doi: 10.1016/j.semcancer.2018.01.008. PMID: 29355614
Cancer of the oropharynx.
Clump DA, Bauman JE, Ferris RL
Surg Oncol Clin N Am 2015 Jul;24(3):509-20. Epub 2015 Apr 15 doi: 10.1016/j.soc.2015.03.014. PMID: 25979397

Diagnosis

Recurrent Respiratory Papilloma of the Larynx.
Huston MN, Naunheim MR, Sadow PM
Mayo Clin Proc 2023 Jun;98(6):945-946. doi: 10.1016/j.mayocp.2023.02.011. PMID: 37270273
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Recurrent respiratory papillomatosis.
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article
Adult laryngotracheal surgery.
Xiao P, Zhang XS
Anesthesiol Clin 2010 Sep;28(3):529-40. doi: 10.1016/j.anclin.2010.07.010. PMID: 20850083
Juvenile laryngeal papillomatosis.
Coope G, Connett G
Prim Care Respir J 2006 Apr;15(2):125-7. Epub 2006 Mar 9 doi: 10.1016/j.pcrj.2006.02.004. PMID: 16701772Free PMC Article

Therapy

Recurrent respiratory papillomatosis.
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article
Adjuvant therapy for laryngeal papillomatosis.
Boltežar IH, Bahar MS, Zargi M, Gale N, Matičič M, Poljak M
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):175-80. PMID: 22131118
Upper airway obstruction in children.
Bruce IA, Rothera MP
Paediatr Anaesth 2009 Jul;19 Suppl 1:88-99. doi: 10.1111/j.1460-9592.2009.03005.x. PMID: 19572848
Therapy for recurrent respiratory papillomatosis.
Auborn KJ
Antivir Ther 2002 Mar;7(1):1-9. PMID: 12008782
Systemic cidofovir in papillomatosis.
Van Valckenborgh I, Wellens W, De Boeck K, Snoeck R, De Clercq E, Feenstra L
Clin Infect Dis 2001 Feb 1;32(3):E62-4. Epub 2001 Jan 23 doi: 10.1086/318497. PMID: 11170974

Prognosis

Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments.
Solomon B, Young RJ, Rischin D
Semin Cancer Biol 2018 Oct;52(Pt 2):228-240. Epub 2018 Jan 31 doi: 10.1016/j.semcancer.2018.01.008. PMID: 29355614
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Recurrent respiratory papillomatosis.
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article
Juvenile laryngeal papillomatosis.
Coope G, Connett G
Prim Care Respir J 2006 Apr;15(2):125-7. Epub 2006 Mar 9 doi: 10.1016/j.pcrj.2006.02.004. PMID: 16701772Free PMC Article

Clinical prediction guides

Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
Low-temperature radiofrequency coblation reduces treatment interval and post-operative pain of laryngotracheal recurrent respiratory papillomatosis.
Hao F, Yue L, Yin X, Wang X, Shan C
Biosci Rep 2020 May 29;40(5) doi: 10.1042/BSR20192005. PMID: 32426815Free PMC Article
p53 mutations in oral cavity carcinoma.
Ragos V, S Mastronikolis N, Tsiambas E, Baliou E, N Mastronikolis S, Tsoukalas N, E Patsouri E, P Fotiades P
J BUON 2018 Nov-Dec;23(6):1569-1572. PMID: 30610778
Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments.
Solomon B, Young RJ, Rischin D
Semin Cancer Biol 2018 Oct;52(Pt 2):228-240. Epub 2018 Jan 31 doi: 10.1016/j.semcancer.2018.01.008. PMID: 29355614
Systemic cidofovir in papillomatosis.
Van Valckenborgh I, Wellens W, De Boeck K, Snoeck R, De Clercq E, Feenstra L
Clin Infect Dis 2001 Feb 1;32(3):E62-4. Epub 2001 Jan 23 doi: 10.1086/318497. PMID: 11170974

Recent systematic reviews

NBI and Laryngeal Papillomatosis: A Diagnostic Challenge: A Systematic Review.
Saraniti C, Gallina S, Verro B
Int J Environ Res Public Health 2022 Jul 18;19(14) doi: 10.3390/ijerph19148716. PMID: 35886569Free PMC Article
Bevacizumab as treatment option for recurrent respiratory papillomatosis: a systematic review.
Pogoda L, Ziylan F, Smeeing DPJ, Dikkers FG, Rinkel RNPM
Eur Arch Otorhinolaryngol 2022 Sep;279(9):4229-4240. Epub 2022 Apr 24 doi: 10.1007/s00405-022-07388-6. PMID: 35462578Free PMC Article
Involvement of Laryngopharyngeal Reflux in Select Nonfunctional Laryngeal Diseases: A Systematic Review.
Lechien JR, Akst LM, Saussez S, Crevier-Buchman L, Hans S, Barillari MR, Calvo-Henriquez C, Bock JM, Carroll TL
Otolaryngol Head Neck Surg 2021 Jan;164(1):37-48. Epub 2020 Jun 23 doi: 10.1177/0194599820933209. PMID: 32571152
Systemic therapy in the curative treatment of head and neck squamous cell cancer: a systematic review.
Winquist E, Agbassi C, Meyers BM, Yoo J, Chan KKW; Head and Neck Disease Site Group
J Otolaryngol Head Neck Surg 2017 Apr 4;46(1):29. doi: 10.1186/s40463-017-0199-x. PMID: 28376866Free PMC Article

Supplemental Content

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

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    Reviews

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