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Bone Demineralization, Pathologic

MedGen UID:
116641
•Concept ID:
C0242699
•
Disease or Syndrome
Synonym: Pathologic Bone Demineralization

Definition

Decrease, loss, or removal of the mineral constituents of bones. Temporary loss of bone mineral content is especially associated with space flight, weightlessness, and extended immobilization. OSTEOPOROSIS is permanent, includes reduction of total bone mass, and is associated with increased rate of fractures. CALCIFICATION, PHYSIOLOGIC is the process of bone remineralizing. (From Dorland, 27th ed; Stedman, 25th ed; Nicogossian, Space Physiology and Medicine, 2d ed, pp327-33) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone Demineralization, Pathologic

Professional guidelines

PubMed

Bone mineralization disorders as a complication of anorexia nervosa - etiology, prevalence, course and treatment.
Jagielska GW, Przedlacki J, Bartoszewicz Z, Racicka E
Psychiatr Pol 2016;50(3):509-20. doi: 10.12740/PP/59289. PMID: 27556110
Calcium nephrolithiasis and bone demineralization: pathophysiology, diagnosis, and medical management.
Arrabal-Polo MA, Cano-García Mdel C, Canales BK, Arrabal-Martín M
Curr Opin Urol 2014 Nov;24(6):633-8. doi: 10.1097/MOU.0000000000000111. PMID: 25188231
Cancer-treatment-induced bone loss, part 1.
Michaud LB, Goodin S
Am J Health Syst Pharm 2006 Mar 1;63(5):419-30. doi: 10.2146/ajhp050045.p1. PMID: 16484516

Recent clinical studies

Etiology

Balancing Altered Calcium Metabolism with Bone Health in Sarcoidosis.
Zhou Y, Lower EE
Semin Respir Crit Care Med 2020 Oct;41(5):618-625. Epub 2020 Aug 10 doi: 10.1055/s-0040-1713009. PMID: 32777848
Antiresorptive and anabolic agents in the prevention and reversal of bone fragility.
Seeman E, Martin TJ
Nat Rev Rheumatol 2019 Apr;15(4):225-236. doi: 10.1038/s41584-019-0172-3. PMID: 30755735
Metabolic Acidosis and Subclinical Metabolic Acidosis in CKD.
Raphael KL
J Am Soc Nephrol 2018 Feb;29(2):376-382. Epub 2017 Oct 13 doi: 10.1681/ASN.2017040422. PMID: 29030467Free PMC Article
Calcium nephrolithiasis and bone demineralization: pathophysiology, diagnosis, and medical management.
Arrabal-Polo MA, Cano-García Mdel C, Canales BK, Arrabal-Martín M
Curr Opin Urol 2014 Nov;24(6):633-8. doi: 10.1097/MOU.0000000000000111. PMID: 25188231
Sodium-phosphate cotransporters, nephrolithiasis and bone demineralization.
Prié D, Beck L, Friedlander G, Silve C
Curr Opin Nephrol Hypertens 2004 Nov;13(6):675-81. doi: 10.1097/00041552-200411000-00015. PMID: 15483460

Diagnosis

Balancing Altered Calcium Metabolism with Bone Health in Sarcoidosis.
Zhou Y, Lower EE
Semin Respir Crit Care Med 2020 Oct;41(5):618-625. Epub 2020 Aug 10 doi: 10.1055/s-0040-1713009. PMID: 32777848
Clinical pearls in gastroenterology.
Henderson PK, Litin SC, Bundrick JB
Dis Mon 2018 Aug;64(8):361-369. Epub 2018 Jun 5 doi: 10.1016/j.disamonth.2018.05.003. PMID: 29880266
Calcium nephrolithiasis and bone demineralization: pathophysiology, diagnosis, and medical management.
Arrabal-Polo MA, Cano-García Mdel C, Canales BK, Arrabal-Martín M
Curr Opin Urol 2014 Nov;24(6):633-8. doi: 10.1097/MOU.0000000000000111. PMID: 25188231
Diabetes mellitus and bone disease in cystic fibrosis.
Curran DR, McArdle JR, Talwalkar JS
Semin Respir Crit Care Med 2009 Oct;30(5):514-30. Epub 2009 Sep 16 doi: 10.1055/s-0029-1238910. PMID: 19760539
Cancer-treatment-induced bone loss, part 1.
Michaud LB, Goodin S
Am J Health Syst Pharm 2006 Mar 1;63(5):419-30. doi: 10.2146/ajhp050045.p1. PMID: 16484516

Therapy

Balancing Altered Calcium Metabolism with Bone Health in Sarcoidosis.
Zhou Y, Lower EE
Semin Respir Crit Care Med 2020 Oct;41(5):618-625. Epub 2020 Aug 10 doi: 10.1055/s-0040-1713009. PMID: 32777848
Antiresorptive and anabolic agents in the prevention and reversal of bone fragility.
Seeman E, Martin TJ
Nat Rev Rheumatol 2019 Apr;15(4):225-236. doi: 10.1038/s41584-019-0172-3. PMID: 30755735
Metabolic Acidosis and Subclinical Metabolic Acidosis in CKD.
Raphael KL
J Am Soc Nephrol 2018 Feb;29(2):376-382. Epub 2017 Oct 13 doi: 10.1681/ASN.2017040422. PMID: 29030467Free PMC Article
Space flight rehabilitation.
Payne MW, Williams DR, Trudel G
Am J Phys Med Rehabil 2007 Jul;86(7):583-91. doi: 10.1097/PHM.0b013e31802b8d09. PMID: 17167347
Pharmacological approaches.
Vernikos J
Acta Astronaut 1995 Feb-Mar;35(4-5):281-95. doi: 10.1016/0094-5765(95)98733-p. PMID: 11541472

Prognosis

Biochemical, bone and renal patterns in hyperparathyroidism associated with multiple endocrine neoplasia type 1.
Lourenço DM Jr, Coutinho FL, Toledo RA, Gonçalves TD, Montenegro FL, Toledo SP
Clinics (Sao Paulo) 2012;67 Suppl 1(Suppl 1):99-108. doi: 10.6061/clinics/2012(sup01)17. PMID: 22584713Free PMC Article
Contribution of bone and mineral abnormalities to cardiovascular disease in patients with chronic kidney disease.
Raggi P, Kleerekoper M
Clin J Am Soc Nephrol 2008 May;3(3):836-43. Epub 2008 Mar 5 doi: 10.2215/CJN.02910707. PMID: 18322050
Clinical applications of bone density testing for osteoporosis.
Lewiecki EM
Minerva Med 2005 Oct;96(5):317-30. PMID: 16227947
Turner syndrome and osteoporosis: mechanisms and prognosis.
Rubin K
Pediatrics 1998 Aug;102(2 Pt 3):481-5. PMID: 9685448
The medical legacy of Gemini.
Berry CA
Life Sci Space Res 1968;6:1-19. PMID: 11982022

Clinical prediction guides

Current concepts regarding calcium metabolism and bone health in sarcoidosis.
Baughman RP, Papanikolaou I
Curr Opin Pulm Med 2017 Sep;23(5):476-481. doi: 10.1097/MCP.0000000000000400. PMID: 28598871
Cardiovascular calcification and subcortical bone demineralization in hypertension.
Cirillo C, Bilancio G, Natale F, Concilio C, Russo MG, Calabrò P, Cirillo M
Hypertens Res 2017 Sep;40(9):825-830. Epub 2017 Apr 6 doi: 10.1038/hr.2017.44. PMID: 28381870
Osteocyte-directed bone demineralization along canaliculi.
Nango N, Kubota S, Hasegawa T, Yashiro W, Momose A, Matsuo K
Bone 2016 Mar;84:279-288. Epub 2015 Dec 17 doi: 10.1016/j.bone.2015.12.006. PMID: 26709236
Sodium-phosphate cotransporters, nephrolithiasis and bone demineralization.
Prié D, Beck L, Friedlander G, Silve C
Curr Opin Nephrol Hypertens 2004 Nov;13(6):675-81. doi: 10.1097/00041552-200411000-00015. PMID: 15483460
The medical legacy of Gemini.
Berry CA
Life Sci Space Res 1968;6:1-19. PMID: 11982022

Recent systematic reviews

Managing bone health with zoledronic acid: a review of randomized clinical study results.
Hadji P
Climacteric 2011 Jun;14(3):321-32. Epub 2010 Dec 23 doi: 10.3109/13697137.2010.529966. PMID: 21182431
Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain.
Jensen TS, Karppinen J, Sorensen JS, Niinimäki J, Leboeuf-Yde C
Eur Spine J 2008 Nov;17(11):1407-22. Epub 2008 Sep 12 doi: 10.1007/s00586-008-0770-2. PMID: 18787845Free PMC Article

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