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Warthin tumor

MedGen UID:
124
Concept ID:
C0001429
Neoplastic Process
Synonym: Papillary cystadenoma lymphomatosum (formerly)
SNOMED CT: Adenolymphoma (422470007); Papillary cystadenoma lymphomatosum (422470007); Warthin's tumor (422470007); Adenolymphoma (20776008); Papillary cystadenoma lymphomatosum (20776008); Warthin's tumor (20776008)
 
Monarch Initiative: MONDO:0006493

Definition

An adenoma characterized by an oncocytic, often papillary, epithelial component, dense lymphoid stroma, and cystic spaces. It occurs primarily in the parotid gland, and is the second most common benign parotid salivary gland tumor. A strong association with smoking has been reported. It typically presents as a painless swelling in the lower portion of the parotid gland. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Katabi N
Head Neck Pathol 2024 Mar 19;18(1):20. doi: 10.1007/s12105-024-01622-9. PMID: 38502259Free PMC Article
Aulich A, Cichocki P, Stefański B, Adamczewski Z
Pol Arch Intern Med 2024 Jan 29;134(1) Epub 2023 Nov 27 doi: 10.20452/pamw.16616. PMID: 38019146
Vlantis AC, Ng SK, Mak CK, Cheung JM, Chan AB, van Hasselt CA
Ear Nose Throat J 2016 Apr-May;95(4-5):185-8. PMID: 27140020

Recent clinical studies

Etiology

Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869Free PMC Article
Dababneh MN, Griffith CC, Patel MR, Magliocca KR
Head Neck Pathol 2021 Jun;15(2):593-598. Epub 2021 Jan 4 doi: 10.1007/s12105-020-01266-5. PMID: 33398686Free PMC Article
Tunç O, Gönüldaş B, Arslanhan Y, Kanlıkama M
Eur Arch Otorhinolaryngol 2020 Dec;277(12):3431-3434. Epub 2020 May 29 doi: 10.1007/s00405-020-06081-w. PMID: 32472159
Citak EC, Yilmaz EB, Sagcan F, Bozkurt F, Arpaci RB, Vayisoglu Y
J Pediatr Hematol Oncol 2019 Aug;41(6):494-497. doi: 10.1097/MPH.0000000000001303. PMID: 30198962
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584

Diagnosis

Sasaki E, Terada H, Oishi N, Iwakoshi A, Masago K, Matsushita H, Yamamoto H, Hanai N, Tateyama H
Virchows Arch 2024 Jun;484(6):945-950. Epub 2023 Nov 13 doi: 10.1007/s00428-023-03701-8. PMID: 37953373
Dababneh MN, Griffith CC, Patel MR, Magliocca KR
Head Neck Pathol 2021 Jun;15(2):593-598. Epub 2021 Jan 4 doi: 10.1007/s12105-020-01266-5. PMID: 33398686Free PMC Article
Heatley N, Harrington KJ, Thway K
Int J Surg Pathol 2018 Feb;26(1):31-33. Epub 2017 Aug 9 doi: 10.1177/1066896917724889. PMID: 28793830
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

Therapy

Aulich A, Cichocki P, Stefański B, Adamczewski Z
Pol Arch Intern Med 2024 Jan 29;134(1) Epub 2023 Nov 27 doi: 10.20452/pamw.16616. PMID: 38019146
Feng B, Wang Z, Cui J, Li J, Xu H, Yu D, Zeng Q, Xiu J
Acad Radiol 2023 Apr;30(4):717-726. Epub 2022 Aug 8 doi: 10.1016/j.acra.2022.06.017. PMID: 35953356
Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869Free PMC Article
Gekeler J, Luers JC, Krohn T, Beutner D
Clin Nucl Med 2010 Feb;35(2):105-6. doi: 10.1097/RLU.0b013e3181c7bf39. PMID: 20090459
Nagler RM, Laufer D
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999 Jun;87(6):735-7. doi: 10.1016/s1079-2104(99)70171-x. PMID: 10397668

Prognosis

Tunç O, Gönüldaş B, Arslanhan Y, Kanlıkama M
Eur Arch Otorhinolaryngol 2020 Dec;277(12):3431-3434. Epub 2020 May 29 doi: 10.1007/s00405-020-06081-w. PMID: 32472159
Citak EC, Yilmaz EB, Sagcan F, Bozkurt F, Arpaci RB, Vayisoglu Y
J Pediatr Hematol Oncol 2019 Aug;41(6):494-497. doi: 10.1097/MPH.0000000000001303. PMID: 30198962
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928
Cope W, Naugler C, Taylor SM, Trites J, Hart RD, Bullock MJ
Head Neck Pathol 2014 Mar;8(1):73-6. Epub 2013 Jul 19 doi: 10.1007/s12105-013-0477-5. PMID: 23868565Free PMC Article
Yaor MA
Ear Nose Throat J 2010 Feb;89(2):E17-21. PMID: 20155665

Clinical prediction guides

Saoud C, Bailey GE, Graham A, Bonilla LM, Sanchez SI, Maleki Z
Acta Cytol 2024;68(3):194-205. Epub 2024 Feb 28 doi: 10.1159/000538069. PMID: 38417405
Werner A, Freesmeyer M, Bensch C, Eszlinger M, Seifert P
Clin Nucl Med 2023 Apr 1;48(4):351-353. Epub 2022 Oct 15 doi: 10.1097/RLU.0000000000004460. PMID: 36252737
Tunç O, Gönüldaş B, Arslanhan Y, Kanlıkama M
Eur Arch Otorhinolaryngol 2020 Dec;277(12):3431-3434. Epub 2020 May 29 doi: 10.1007/s00405-020-06081-w. PMID: 32472159
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928
Cope W, Naugler C, Taylor SM, Trites J, Hart RD, Bullock MJ
Head Neck Pathol 2014 Mar;8(1):73-6. Epub 2013 Jul 19 doi: 10.1007/s12105-013-0477-5. PMID: 23868565Free PMC Article

Recent systematic reviews

Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869Free PMC Article

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