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Breast Paget Disease and Intraductal Carcinoma

MedGen UID:
124632
•Concept ID:
C0279566
•
Neoplastic Process
Synonyms: Paget disease and intraductal carcinoma of breast; Paget Disease and Intraductal Carcinoma of the Breast; Paget's disease and intraductal carcinoma of breast; Paget's Disease and Intraductal Carcinoma of Breast; Paget's Disease and Intraductal Carcinoma of the Breast; Paget's Disease of Breast with Intraductal Carcinoma; Paget's Disease of the Breast with Intraductal Carcinoma
SNOMED CT: Paget disease and intraductal carcinoma of breast (54666007); Paget's disease and intraductal carcinoma of breast (54666007)

Definition

Paget disease of the breast associated with the presence of a usually high grade ductal carcinoma in situ in the lactiferous glands. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Paget Disease and Intraductal Carcinoma

Professional guidelines

PubMed

Time for detailed clinical management of Paget's disease of the breast.
Li C, Wang Y, Liu M, Qu J, Zhang S
Int J Surg 2024 Feb 1;110(2):1266-1267. doi: 10.1097/JS9.0000000000000855. PMID: 37889547Free PMC Article
Paget's disease of the breast: diagnosis and management.
Hudson-Phillips S, Cox K, Patel P, Al Sarakbi W
Br J Hosp Med (Lond) 2023 Jan 2;84(1):1-8. Epub 2023 Jan 24 doi: 10.12968/hmed.2022.0439. PMID: 36708338
Breast Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology.
Gradishar WJ, Moran MS, Abraham J, Aft R, Agnese D, Allison KH, Anderson B, Burstein HJ, Chew H, Dang C, Elias AD, Giordano SH, Goetz MP, Goldstein LJ, Hurvitz SA, Isakoff SJ, Jankowitz RC, Javid SH, Krishnamurthy J, Leitch M, Lyons J, Mortimer J, Patel SA, Pierce LJ, Rosenberger LH, Rugo HS, Sitapati A, Smith KL, Smith ML, Soliman H, Stringer-Reasor EM, Telli ML, Ward JH, Wisinski KB, Young JS, Burns J, Kumar R
J Natl Compr Canc Netw 2022 Jun;20(6):691-722. doi: 10.6004/jnccn.2022.0030. PMID: 35714673

Recent clinical studies

Etiology

Florid papillomatosis of the nipple: a rare presentation and review of the literature.
Salemis NS
Breast Dis 2015;35(2):153-6. doi: 10.3233/BD-150397. PMID: 25585841
Adenoma of the nipple in an adolescent.
Sugai M, Murata K, Kimura N, Munakata H, Hada R, Kamata Y
Breast Cancer 2002;9(3):254-6. doi: 10.1007/BF02967598. PMID: 12185338
Paget's disease of the male breast: a clinicopathologic study and a collective review.
Gupta S, Khanna NN, Khanna S, Gupta S
J Surg Oncol 1983 Mar;22(3):151-6. doi: 10.1002/jso.2930220303. PMID: 6300558
Paget's disease of the breast.
Ashikari R, Park K, Huvos AG, Urban JA
Cancer 1970 Sep;26(3):680-5. doi: 10.1002/1097-0142(197009)26:3<680::aid-cncr2820260329>3.0.co;2-p. PMID: 4318756
Paget's disease of the breast.
Nance FC, DeLoach DH, Welsh RA, Becker WF
Ann Surg 1970 Jun;171(6):864-74. doi: 10.1097/00000658-197006010-00007. PMID: 4316089Free PMC Article

Diagnosis

Mammary Paget disease.
Brufau-Cochs M, Guilarte-Cadavide C, Ferrer-Artola M
Med Clin (Barc) 2024 Jul 12;163(1):e2. Epub 2024 Jan 28 doi: 10.1016/j.medcli.2023.11.022. PMID: 38286721
Time for detailed clinical management of Paget's disease of the breast.
Li C, Wang Y, Liu M, Qu J, Zhang S
Int J Surg 2024 Feb 1;110(2):1266-1267. doi: 10.1097/JS9.0000000000000855. PMID: 37889547Free PMC Article
Paget's Disease of the Breast.
Akham R, Hazarika N
N Engl J Med 2023 Mar 23;388(12):1126. Epub 2023 Mar 18 doi: 10.1056/NEJMicm2210124. PMID: 36942776
Paget's disease of the breast: diagnosis and management.
Hudson-Phillips S, Cox K, Patel P, Al Sarakbi W
Br J Hosp Med (Lond) 2023 Jan 2;84(1):1-8. Epub 2023 Jan 24 doi: 10.12968/hmed.2022.0439. PMID: 36708338
Penoscrotal Paget's disease.
Dauendorffer JN, Herms F, Baroudjian B, Basset-Seguin N, Cavelier-Balloy B, Fouéré S, Bagot M, Lebbé C
Ann Dermatol Venereol 2021 Jun;148(2):71-76. Epub 2021 Jan 16 doi: 10.1016/j.annder.2020.08.051. PMID: 33461789

Therapy

Mammary Paget's disease and radiotherapy: a systematic literature review.
Piras A, Boldrini L, Venuti V, Sanfratello A, La Vecchia M, Gennari R, Sortino G, Angileri T, Daidone A
Eur Rev Med Pharmacol Sci 2021 Feb;25(4):1821-1827. doi: 10.26355/eurrev_202102_25076. PMID: 33660791
Cutaneous schistosomiasis mimicking Paget's disease of the breast.
Pennell L, Seddon I, Anwar I
Breast J 2011 Jan-Feb;17(1):99-100. doi: 10.1111/j.1524-4741.2010.01030.x. PMID: 21251124
Dermatoses of the nipple.
Parlakgumus A, Yildirim S, Bolat FA, Caliskan K, Ezer A, Colakoglu T, Moray G
Can J Surg 2009 Apr;52(2):160-1. PMID: 19399214Free PMC Article
Dermatologic diseases of the breast in young women.
Ward KA, Burton JL
Clin Dermatol 1997 Jan-Feb;15(1):45-52. doi: 10.1016/s0738-081x(96)00109-5. PMID: 9034655
Carcinoma of the male breast: a thirty year experience and literature review.
Roswit B, Edlis H
Int J Radiat Oncol Biol Phys 1978 Jul-Aug;4(7-8):711-6. doi: 10.1016/0360-3016(78)90201-8. PMID: 213409

Prognosis

Adenoma of the nipple in an adolescent.
Sugai M, Murata K, Kimura N, Munakata H, Hada R, Kamata Y
Breast Cancer 2002;9(3):254-6. doi: 10.1007/BF02967598. PMID: 12185338
Significance of eczema in Paget's disease of the breast.
Maor M
Eur J Cancer (1965) 1979 Jan;15(1):35-8. doi: 10.1016/0014-2964(79)90202-0. PMID: 217690
Paget's disease of the male breast.
Coley GM, Kuehn PG
Am J Surg 1972 Apr;123(4):444-50. doi: 10.1016/0002-9610(72)90198-5. PMID: 4335279
Paget's disease of the breast.
Ashikari R, Park K, Huvos AG, Urban JA
Cancer 1970 Sep;26(3):680-5. doi: 10.1002/1097-0142(197009)26:3<680::aid-cncr2820260329>3.0.co;2-p. PMID: 4318756
Paget's disease of the breast.
Nance FC, DeLoach DH, Welsh RA, Becker WF
Ann Surg 1970 Jun;171(6):864-74. doi: 10.1097/00000658-197006010-00007. PMID: 4316089Free PMC Article

Clinical prediction guides

Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Overall and cancer-specific survival in patients with breast Paget disease: A population-based study.
Hu T, Chen Z, Hou M, Lin K
Exp Biol Med (Maywood) 2022 Feb;247(3):187-199. Epub 2021 Nov 29 doi: 10.1177/15353702211056264. PMID: 34842487Free PMC Article
Breast-Conserving Surgery in Patients With Mammary Paget's Disease.
Yao Y, Sun L, Meng Y, Zhuang Y, Zhao L, Yu Q, Si C
J Surg Res 2019 Sep;241:178-187. Epub 2019 Apr 24 doi: 10.1016/j.jss.2019.03.025. PMID: 31026796
Ultrastructure of the human breast and its disorders.
Fisher ER
Am J Clin Pathol 1976 Aug;66(2):291-375. doi: 10.1093/ajcp/66.2.291. PMID: 181979
Ultrastructural observations on epidermal cells in Paget's disease of the breast.
Sagebiel RW
Am J Pathol 1969 Oct;57(1):49-64. PMID: 4310578Free PMC Article

Recent systematic reviews

Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Mammary Paget's disease and radiotherapy: a systematic literature review.
Piras A, Boldrini L, Venuti V, Sanfratello A, La Vecchia M, Gennari R, Sortino G, Angileri T, Daidone A
Eur Rev Med Pharmacol Sci 2021 Feb;25(4):1821-1827. doi: 10.26355/eurrev_202102_25076. PMID: 33660791
Paget's disease of the male breast in the 21st century: A systematic review.
Adams SJ, Kanthan R
Breast 2016 Oct;29:14-23. Epub 2016 Jul 6 doi: 10.1016/j.breast.2016.06.015. PMID: 27394005
Breast-conserving surgery in patients with Paget's disease.
Helme S, Harvey K, Agrawal A
Br J Surg 2015 Sep;102(10):1167-74. Epub 2015 Jul 14 doi: 10.1002/bjs.9863. PMID: 26175231
Effectiveness of photodynamic therapy for mammary and extra-mammary Paget's disease: a state of the science review.
Nardelli AA, Stafinski T, Menon D
BMC Dermatol 2011 Jun 15;11:13. doi: 10.1186/1471-5945-11-13. PMID: 21676258Free PMC Article

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