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Lip and oral cavity squamous cell carcinoma

MedGen UID:
124714
•Concept ID:
C0280297
•
Neoplastic Process
Synonyms: lip and oral cavity squamous cell cancer; Lip and Oral Cavity Squamous Cell Carcinoma; lip and oral cavity squamous cell carcinoma; lip/oral cavity squam. cell car.; squamous cell carcinoma of oral cavity and lip; Squamous cell carcinoma of oral cavity and lip
 
Monarch Initiative: MONDO:0044710
Orphanet: ORPHA502369

Definition

A squamous cell carcinoma arising from the lip or the oral cavity. The oral cavity squamous cell carcinoma usually arises from the buccal mucosa, tongue, or gums. It occurs predominantly in adults who use tobacco and alcohol and has a tendency to metastasize early to lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLip and oral cavity squamous cell carcinoma

Professional guidelines

PubMed

Potential Alternative Therapeutic Modalities for Management Head and Neck Squamous Cell Carcinoma: A Review.
Afshari K, Sohal KS
Cancer Control 2023 Jan-Dec;30:10732748231185003. doi: 10.1177/10732748231185003. PMID: 37328298Free PMC Article
Management of high-risk squamous cell carcinoma of the skin.
Samarasinghe V, Madan V, Lear JT
Expert Rev Anticancer Ther 2011 May;11(5):763-9. doi: 10.1586/era.11.36. PMID: 21554051
Brachytherapy in head and neck cancer: selection criteria and results at the University of Florida.
Mendenhall WM, Parsons JT, Mendenhall NP, Million RR
Oncology (Williston Park) 1991 Feb;5(2):44-54; discussion 59-60. PMID: 1826208

Recent clinical studies

Etiology

Nodal Metastasis in Surgically Treated Oral Cavity Squamous Cell Carcinoma.
Carey RM, Anagnos VJ, Prasad A, Sangal NR, Rajasekaran K, Shanti RM, Cannady SB, Newman JG, Brant JA, Brody RM
ORL J Otorhinolaryngol Relat Spec 2023;85(6):348-359. Epub 2023 Nov 15 doi: 10.1159/000534491. PMID: 37967536Free PMC Article
Lip and Oral Cavity Squamous Cell Carcinoma.
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Lymphangiogenesis and angiogenesis in oral cavity and lower lip squamous cell carcinoma.
Alaeddini M, Etemad-Moghadam S
Braz J Otorhinolaryngol 2016 Jul-Aug;82(4):385-90. Epub 2015 Nov 5 doi: 10.1016/j.bjorl.2015.06.008. PMID: 26614046Free PMC Article
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013
Management of neck metastases in T2N0 lip squamous cell carcinoma.
Vanderlei JP, Pereira-Filho FJ, da Cruz FA, de Mello FL, Kruschewsky Lde S, de Freitas LC, de Mello-Filho FV
Am J Otolaryngol 2013 Mar-Apr;34(2):103-6. Epub 2012 Nov 17 doi: 10.1016/j.amjoto.2012.09.007. PMID: 23164629

Diagnosis

Lip Squamous Cell Carcinoma With Spontaneous Eruption and Drainage.
Toni T, Allen CT, Mydlarz WK
JAMA Otolaryngol Head Neck Surg 2023 Mar 1;149(3):280-281. doi: 10.1001/jamaoto.2022.4828. PMID: 36729450Free PMC Article
Lip and Oral Cavity Squamous Cell Carcinoma.
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Oral Biopsy Techniques.
Shanti RM, Tanaka T, Stanton DC
Dermatol Clin 2020 Oct;38(4):421-427. Epub 2020 Aug 10 doi: 10.1016/j.det.2020.05.003. PMID: 32892851
Oral paracoccidiodomycosis mimicking lip carcinoma.
Girardi FM, Scrofernecker ML
Braz J Infect Dis 2016 Jan-Feb;20(1):103-4. Epub 2015 Nov 25 doi: 10.1016/j.bjid.2015.08.015. PMID: 26626167Free PMC Article
Congenital epulis.
Merglová V, Mukensnabl P, Andrle P
BMJ Case Rep 2012 Jul 9;2012 doi: 10.1136/bcr.01.2012.5483. PMID: 22778448Free PMC Article

Therapy

Locally advanced head and neck squamous cell carcinoma and melanoma simultaneously treated with pembrolizumab: an unusual situation.
Mora-Fernández V, Boada A, Manzano JL, Jaka A, Ferrándiz C
Eur J Dermatol 2020 Dec 1;30(6):743-744. doi: 10.1684/ejd.2020.3911. PMID: 33237032
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
A Review of Photodynamic Therapy for Neoplasms of the Head and Neck.
Civantos FJ, Karakullukcu B, Biel M, Silver CE, Rinaldo A, Saba NF, Takes RP, Vander Poorten V, Ferlito A
Adv Ther 2018 Mar;35(3):324-340. Epub 2018 Feb 7 doi: 10.1007/s12325-018-0659-3. PMID: 29417455
Selective cytotoxic effect of topical 5-fluorouracil.
Dillaha CJ, Jansen GT, Honeycutt WM, Bradford AC
Arch Dermatol 1983 Sep;119(9):774-83. PMID: 6614965
The integration of chemotherapy into a combined modality approached to cancer therapy. V. Squamous cell cancer of the head and neck.
Goldsmith MA, Carter SK
Cancer Treat Rev 1975 Jun;2(2):137-58. doi: 10.1016/s0305-7372(75)80007-7. PMID: 52406

Prognosis

Nodal Metastasis in Surgically Treated Oral Cavity Squamous Cell Carcinoma.
Carey RM, Anagnos VJ, Prasad A, Sangal NR, Rajasekaran K, Shanti RM, Cannady SB, Newman JG, Brant JA, Brody RM
ORL J Otorhinolaryngol Relat Spec 2023;85(6):348-359. Epub 2023 Nov 15 doi: 10.1159/000534491. PMID: 37967536Free PMC Article
Primary Intraosseous Squamous Cell Carcinoma Involving the Jaw Bones: A Systematic Review and Update.
de Morais EF, Carlan LM, de Farias Morais HG, Pinheiro JC, Martins HDD, Barboza CAG, de Almeida Freitas R
Head Neck Pathol 2021 Jun;15(2):608-616. Epub 2020 Oct 12 doi: 10.1007/s12105-020-01234-z. PMID: 33044723Free PMC Article
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013
Cancer of the perioral region.
Goslen JB, Thomas JR
Dermatol Clin 1989 Oct;7(4):733-49. PMID: 2676286
The dissemination of tumors of the head and neck via the cranial nerves.
Dodd GD, Dolan PA, Ballantyne AJ, Ibanez ML, Chau P
Radiol Clin North Am 1970 Dec;8(3):445-61. PMID: 4923905

Clinical prediction guides

Nodal Metastasis in Surgically Treated Oral Cavity Squamous Cell Carcinoma.
Carey RM, Anagnos VJ, Prasad A, Sangal NR, Rajasekaran K, Shanti RM, Cannady SB, Newman JG, Brant JA, Brody RM
ORL J Otorhinolaryngol Relat Spec 2023;85(6):348-359. Epub 2023 Nov 15 doi: 10.1159/000534491. PMID: 37967536Free PMC Article
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013
Management of neck metastases in T2N0 lip squamous cell carcinoma.
Vanderlei JP, Pereira-Filho FJ, da Cruz FA, de Mello FL, Kruschewsky Lde S, de Freitas LC, de Mello-Filho FV
Am J Otolaryngol 2013 Mar-Apr;34(2):103-6. Epub 2012 Nov 17 doi: 10.1016/j.amjoto.2012.09.007. PMID: 23164629
Selective cytotoxic effect of topical 5-fluorouracil.
Dillaha CJ, Jansen GT, Honeycutt WM, Bradford AC
Arch Dermatol 1983 Sep;119(9):774-83. PMID: 6614965

Recent systematic reviews

Rate of occult metastasis in lip squamous cell carcinoma: A systematic review and meta-analysis.
Kansara S, Oral E, Sarkar I, Sandulache V, Mualla R, Walvekar RR, Ryan W, Ha P
Head Neck 2024 Oct;46(10):2517-2523. Epub 2024 Mar 18 doi: 10.1002/hed.27747. PMID: 38497534
Hydrochlorothiazide use is associated with the risk of cutaneous and lip squamous cell carcinoma: A systematic review and meta-analysis.
de Macedo Andrade AC, Felix FA, França GM, Ribeiro ILA, Barboza CAG, de Castro RD, de Lisboa Lopes Costa A
Eur J Clin Pharmacol 2022 Jun;78(6):919-930. Epub 2022 Mar 8 doi: 10.1007/s00228-022-03299-x. PMID: 35258665
Primary Intraosseous Squamous Cell Carcinoma Involving the Jaw Bones: A Systematic Review and Update.
de Morais EF, Carlan LM, de Farias Morais HG, Pinheiro JC, Martins HDD, Barboza CAG, de Almeida Freitas R
Head Neck Pathol 2021 Jun;15(2):608-616. Epub 2020 Oct 12 doi: 10.1007/s12105-020-01234-z. PMID: 33044723Free PMC Article
Identifying risk factors for the prognosis of head and neck cutaneous squamous cell carcinoma: A systematic review and meta-analysis.
Zeng S, Fu L, Zhou P, Ling H
PLoS One 2020;15(9):e0239586. Epub 2020 Sep 29 doi: 10.1371/journal.pone.0239586. PMID: 32991600Free PMC Article
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013

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