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Hidradenocarcinoma

MedGen UID:
137746
•Concept ID:
C0334344
•
Neoplastic Process
Synonyms: Clear Cell Eccrine Carcinoma; clear cell eccrine carcinoma; hidradenocarcinoma; Nodular hidradenoma, malignant; Sweat gland adenocarcinoma
SNOMED CT: Hidradenocarcinoma (128894005); Nodular hidradenoma, malignant (128894005); Sweat gland adenocarcinoma (254709009); Hidradenocarcinoma (1293105001); Sweat gland adenocarcinoma (32272007)
 
Monarch Initiative: MONDO:0006245

Definition

A carcinoma with apocrine and less often eccrine differentiation, arising from the sweat glands. It usually presents as a solitary slow growing nodule in the dermis or subcutaneous tissues. It is characterized by a nodular growth pattern and it is often associated with necrotic changes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHidradenocarcinoma

Recent clinical studies

Etiology

Hidradenocarcinoma: A Case Series From the Scripps Clinic With a Systematic Review of the Literature.
Kent S, Jeha GM, Qiblawi S, Malinosky H, Greenway HT, Kelley B
Dermatol Surg 2024 Jun 1;50(6):507-511. Epub 2024 Mar 8 doi: 10.1097/DSS.0000000000004140. PMID: 38460197
Sweat Gland Tumors Arising on Acral Sites: A Molecular Survey.
Kervarrec T, Tallet A, Macagno N, de la Fouchardière A, Pissaloux D, Tirode F, Bravo IG, Nicolas A, Baulande S, Sohier P, Balme B, Osio A, Jullie ML, Moulonguet I, Bonsang B, Tournier E, Herfs M, Frouin E, Zidan A, Calonje E, Berthon P, Touzé A, Seris A, Mortier L, Jouary T, Cribier B, Battistella M
Am J Surg Pathol 2023 Oct 1;47(10):1096-1107. Epub 2023 Jul 31 doi: 10.1097/PAS.0000000000002098. PMID: 37505808
Clinicopathological and genomic copy number variation analysis in nodular hidradenoma and hidradenocarcinoma with focus on prognostically important features.
Jiang H, Shah K, Reed KA, Gliem TJ, Guo R
Hum Pathol 2022 Nov;129:103-112. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.004. PMID: 36075320
The risk of lymph node involvement in malignant cutaneous adnexal tumors.
Barnes M, Hestley A, Murray DR, Carlson GW, Parker D, Delman KA
Am Surg 2014 Mar;80(3):270-4. PMID: 24666868
No sweat, a rare case of hidradenocarcinoma.
Singh R, Brewer J, Bernstein ZP, Higgs D
Am Surg 2012 Feb;78(2):92-3. PMID: 22369809

Diagnosis

Hidradenocarcinoma.
de Lima AA, Santos M, de Morais PM, Rodrigues CAC
An Bras Dermatol 2021 Mar-Apr;96(2):251-253. Epub 2021 Feb 5 doi: 10.1016/j.abd.2020.03.023. PMID: 33597101Free PMC Article
Hidradenocarcinoma: a rare but challenging diagnosis.
Moore JA, Cui S, Berger N, Kim S, O'Guinn D, Labow D, Kamath A
Clin Imaging 2021 Jul;75:138-142. Epub 2021 Feb 2 doi: 10.1016/j.clinimag.2021.01.024. PMID: 33549922
Hidradenocarcinoma of the Scrotum.
Barbosa JABA, Ribeiro CTA, Grinblat B, Cardoso APG, Weltmann E, de Oliveira EC, Yorioka MAW, Borges LL
Urology 2019 Nov;133:e13-e14. Epub 2019 Jul 11 doi: 10.1016/j.urology.2019.07.002. PMID: 31302136
Malignant Sweat Gland Tumors.
Ahn CS, Sangüeza OP
Hematol Oncol Clin North Am 2019 Feb;33(1):53-71. doi: 10.1016/j.hoc.2018.09.002. PMID: 30497677
Hidradenocarcinoma: a sinister diagnosis of a suspected benign condition.
Bhullar JS, Varshney N, Mervak T, Mittal V, Silapaswan S
Am Surg 2014 Dec;80(12):1271-2. PMID: 25513929

Therapy

Based on Immune Microenvironment and Genomic Status, Exploring Immunotherapy in Advanced Hidradenocarcinoma: A Retrospective Analysis.
Lin J, Zhu L, Chen Y, Li Q, Ke Z, Zhang H, Huang Y, Lu J, Chen Y
Acta Derm Venereol 2024 May 13;104:adv22146. doi: 10.2340/actadv.v104.22146. PMID: 38738772Free PMC Article
Successful treatment of hidradenocarcinoma using ALA-PDT combined with local narrow margin excision.
Lu F, Gu Y, Liao C, Cao Y, Zhao Y, Wu M, Wen L, Wu F, Zhao Z, Zhang G
Photodiagnosis Photodyn Ther 2023 Dec;44:103791. Epub 2023 Sep 28 doi: 10.1016/j.pdpdt.2023.103791. PMID: 37775040
Clear cell hidradenocarcinoma of the breast: a very rare breast skin tumor.
Mezzabotta M, Declich P, Cardarelli M, Bellone S, Pacilli P, Riggio E, Pallino A
Tumori 2012 Mar-Apr;98(2):43e-45e. doi: 10.1700/1088.11947. PMID: 22678002
Clear cell hidradenocarcinoma developing in pacemaker pocket.
Reyes CV
Pacing Clin Electrophysiol 2008 Nov;31(11):1513-5. doi: 10.1111/j.1540-8159.2008.01217.x. PMID: 18950311
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications.
Nash JW, Barrett TL, Kies M, Ross MI, Sneige N, Diwan AH, Lazar AJ
J Cutan Pathol 2007 Jan;34(1):49-54. doi: 10.1111/j.1600-0560.2006.00570.x. PMID: 17214855

Prognosis

Metastatic hidradenocarcinoma: a report of two rare cases.
Amoedo P, Cerejeira A, Moreira F, Coelho A, Barros AM, Moreira E, Magina S, Silva-Ramos M, Azevedo F
Eur J Dermatol 2023 Jun 1;33(3):241-244. doi: 10.1684/ejd.2023.4478. PMID: 37594329
Incidence and trends of cutaneous adnexal tumors in the United States in 2000-2018: A population-based study.
Gibbs DC, Yeung H, Blalock TW
J Am Acad Dermatol 2023 Jan;88(1):226-228. Epub 2022 May 4 doi: 10.1016/j.jaad.2022.04.052. PMID: 35525505Free PMC Article
Clinicopathological and genomic copy number variation analysis in nodular hidradenoma and hidradenocarcinoma with focus on prognostically important features.
Jiang H, Shah K, Reed KA, Gliem TJ, Guo R
Hum Pathol 2022 Nov;129:103-112. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.004. PMID: 36075320
A case of eccrine porocarcinoma characterized by a progressive increase in the level of Ki-67 index: case report and review of literature.
Shen J, Pan X, Lu Y, Pan D, Ma Y, Zhan R
BMC Surg 2019 Oct 10;19(1):142. doi: 10.1186/s12893-019-0595-4. PMID: 31601219Free PMC Article
The risk of lymph node involvement in malignant cutaneous adnexal tumors.
Barnes M, Hestley A, Murray DR, Carlson GW, Parker D, Delman KA
Am Surg 2014 Mar;80(3):270-4. PMID: 24666868

Clinical prediction guides

Ancillary immunohistochemical and molecular testing in the classification of cutaneous sweat gland/duct neoplasms: A validation study with emphasis on histomorphologic correlation and pathological diagnosis.
Nguyen AJ, Johnson E, Camilleri M, Wieland C, Lehman JS, Agrawal S, Comfere N, Fadra N, Knudson RA, Greipp P, Halling K, Ray Guo R
Hum Pathol 2024 Aug;150:1-8. Epub 2024 Jun 12 doi: 10.1016/j.humpath.2024.06.006. PMID: 38876201
Sweat Gland Tumors Arising on Acral Sites: A Molecular Survey.
Kervarrec T, Tallet A, Macagno N, de la Fouchardière A, Pissaloux D, Tirode F, Bravo IG, Nicolas A, Baulande S, Sohier P, Balme B, Osio A, Jullie ML, Moulonguet I, Bonsang B, Tournier E, Herfs M, Frouin E, Zidan A, Calonje E, Berthon P, Touzé A, Seris A, Mortier L, Jouary T, Cribier B, Battistella M
Am J Surg Pathol 2023 Oct 1;47(10):1096-1107. Epub 2023 Jul 31 doi: 10.1097/PAS.0000000000002098. PMID: 37505808
Prognostic analysis of hidradenocarcinoma: a SEER-based observational study.
Gao T, Pan S, Li M, Su R
Ann Med 2022 Dec;54(1):454-463. doi: 10.1080/07853890.2022.2032313. PMID: 35107407Free PMC Article
A case of eccrine porocarcinoma characterized by a progressive increase in the level of Ki-67 index: case report and review of literature.
Shen J, Pan X, Lu Y, Pan D, Ma Y, Zhan R
BMC Surg 2019 Oct 10;19(1):142. doi: 10.1186/s12893-019-0595-4. PMID: 31601219Free PMC Article
Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature.
Ohta M, Hiramoto M, Fujii M, Togo T
Dermatol Surg 2004 Sep;30(9):1265-8. doi: 10.1111/j.1524-4725.2004.30390.x. PMID: 15355375

Recent systematic reviews

Hidradenocarcinoma: A Case Series From the Scripps Clinic With a Systematic Review of the Literature.
Kent S, Jeha GM, Qiblawi S, Malinosky H, Greenway HT, Kelley B
Dermatol Surg 2024 Jun 1;50(6):507-511. Epub 2024 Mar 8 doi: 10.1097/DSS.0000000000004140. PMID: 38460197

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