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Clear cell adenocarcinoma

MedGen UID:
64629
•Concept ID:
C0206681
•
Neoplastic Process
Synonyms: Adenocarcinoma, Clear Cell; Adenocarcinomas, Clear Cell; Clear Cell Adenocarcinoma; Clear Cell Adenocarcinomas
SNOMED CT: Mesonephroid clear cell adenocarcinoma (30546008); Clear cell adenocarcinoma (30546008); Clear cell carcinoma (30546008)
 
Monarch Initiative: MONDO:0005004

Definition

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClear cell adenocarcinoma

Professional guidelines

PubMed

Uncommon Cervical Lesions: A Review and Discussion of the Differential Diagnosis.
Griesinger LM, Szczepanski JM, McMullen ER, Skala SL
Arch Pathol Lab Med 2021 Jul 1;145(7):891-902. doi: 10.5858/arpa.2020-0327-RA. PMID: 33091926
Management and clinical outcomes of patients with recurrent/progressive ovarian clear cell carcinoma.
Huang HJ, Yang LY, Tung HJ, Ku FC, Wu RC, Tang YH, Chang WY, Jung SM, Wang CC, Lin CT, Liu FY, Lin G, Chen MY, Chou HH, Chang TC, Chao A, Lai CH
J Formos Med Assoc 2020 Apr;119(4):793-804. Epub 2019 Dec 6 doi: 10.1016/j.jfma.2019.11.018. PMID: 31818713
Successful surgical treatment and chemotherapy for ovarian cancer in a patient with idiopathic thrombocytopenic purpura.
Wakana K, Yasugi T, Nako Y, Nei T, Ozaki Y, Mizutani K
Int J Clin Oncol 2011 Aug;16(4):447-9. Epub 2010 Dec 4 doi: 10.1007/s10147-010-0149-3. PMID: 21132452

Recent clinical studies

Etiology

Clear cell carcinoma of the ovary and venous thromboembolism: a systematic review and meta-analysis.
Didar H, Farzaneh F, Najafiarab H, Namakin K, Gohari K, Sheidaei A, Ramezani S
Curr Med Res Opin 2023 Jun;39(6):901-910. Epub 2023 May 7 doi: 10.1080/03007995.2023.2208488. PMID: 37104696
Clear cell carcinoma of the ovary: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, Cosio S, Carinelli S, Ghioni M, Aletti GD
Gynecol Oncol 2021 Sep;162(3):741-750. Epub 2021 Jul 8 doi: 10.1016/j.ygyno.2021.06.033. PMID: 34247767
Endometriosis-associated Ovarian Cancers.
Anglesio MS, Yong PJ
Clin Obstet Gynecol 2017 Dec;60(4):711-727. doi: 10.1097/GRF.0000000000000320. PMID: 28990985
Clear cell carcinoma, not otherwise specified/hyalinising clear cell carcinoma of the salivary gland: The current nomenclature, clinical/pathological characteristics and management.
Daniele L, Nikolarakos D, Keenan J, Schaefer N, Lam AK
Crit Rev Oncol Hematol 2016 Jun;102:55-64. Epub 2016 Apr 9 doi: 10.1016/j.critrevonc.2016.03.018. PMID: 27150676
Clear cell carcinoma of the female genital tract (not everything is as clear as it seems).
Offman SL, Longacre TA
Adv Anat Pathol 2012 Sep;19(5):296-312. doi: 10.1097/PAP.0b013e31826663b1. PMID: 22885379

Diagnosis

Clear cell carcinoma of the ovary: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, Cosio S, Carinelli S, Ghioni M, Aletti GD
Gynecol Oncol 2021 Sep;162(3):741-750. Epub 2021 Jul 8 doi: 10.1016/j.ygyno.2021.06.033. PMID: 34247767
Translational genomics of ovarian clear cell carcinoma.
Khalique S, Lord CJ, Banerjee S, Natrajan R
Semin Cancer Biol 2020 Apr;61:121-131. Epub 2019 Nov 4 doi: 10.1016/j.semcancer.2019.10.025. PMID: 31698086
Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary.
Fadare O, Parkash V
Surg Pathol Clin 2019 Jun;12(2):529-564. doi: 10.1016/j.path.2019.01.009. PMID: 31097114
Clear cell carcinoma of testis: A review.
Lin M, Awalt H, Ayala AG, Ro JY
Ann Diagn Pathol 2019 Jun;40:26-29. Epub 2019 Mar 20 doi: 10.1016/j.anndiagpath.2019.03.002. PMID: 30921621
Clear cell carcinoma of the ovary: molecular insights and future therapeutic perspectives.
Mabuchi S, Sugiyama T, Kimura T
J Gynecol Oncol 2016 May;27(3):e31. doi: 10.3802/jgo.2016.27.e31. PMID: 27029752Free PMC Article

Therapy

New therapies for clear cell ovarian carcinoma.
Stewart J, Cunningham N, Banerjee S
Int J Gynecol Cancer 2023 Mar 6;33(3):385-393. doi: 10.1136/ijgc-2022-003704. PMID: 36878571
Clear cell carcinoma of the ovary: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, Cosio S, Carinelli S, Ghioni M, Aletti GD
Gynecol Oncol 2021 Sep;162(3):741-750. Epub 2021 Jul 8 doi: 10.1016/j.ygyno.2021.06.033. PMID: 34247767
Clear Cell Conundrum.
Schroeder SR, Albuquerque K
Int J Radiat Oncol Biol Phys 2019 Nov 15;105(4):690-691. doi: 10.1016/j.ijrobp.2018.02.167. PMID: 31655652
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Diethylstilboestrol--a long-term legacy.
Harris RM, Waring RH
Maturitas 2012 Jun;72(2):108-12. Epub 2012 Mar 29 doi: 10.1016/j.maturitas.2012.03.002. PMID: 22464649

Prognosis

Primary Clear Cell Adenocarcinoma of the Head and Neck: A Population-Based Analysis.
Mukdad L, Han AY, Badran K, Alonso JE, Nasser HB, Goel AN, St John MA
Otolaryngol Head Neck Surg 2020 Apr;162(4):498-503. Epub 2020 Feb 4 doi: 10.1177/0194599820903028. PMID: 32013719
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Invasive Epithelial Ovarian Cancer Survival by Histotype and Disease Stage.
Peres LC, Cushing-Haugen KL, Köbel M, Harris HR, Berchuck A, Rossing MA, Schildkraut JM, Doherty JA
J Natl Cancer Inst 2019 Jan 1;111(1):60-68. doi: 10.1093/jnci/djy071. PMID: 29718305Free PMC Article
Clear cell adenocarcinoma of the vagina and cervix secondary to intrauterine exposure to diethylstilbestrol.
Herbst AL, Anderson D
Semin Surg Oncol 1990;6(6):343-6. doi: 10.1002/ssu.2980060609. PMID: 2263810
Clear cell adenocarcinoma of the ovary: a clinical analysis and comparison with serous carcinoma.
Jenison EL, Montag AG, Griffiths CT, Welch WR, Lavin PT, Greer J, Knapp RC
Gynecol Oncol 1989 Jan;32(1):65-71. doi: 10.1016/0090-8258(89)90852-4. PMID: 2642454

Clinical prediction guides

New therapies for clear cell ovarian carcinoma.
Stewart J, Cunningham N, Banerjee S
Int J Gynecol Cancer 2023 Mar 6;33(3):385-393. doi: 10.1136/ijgc-2022-003704. PMID: 36878571
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Clear cell carcinoma of testis: A review.
Lin M, Awalt H, Ayala AG, Ro JY
Ann Diagn Pathol 2019 Jun;40:26-29. Epub 2019 Mar 20 doi: 10.1016/j.anndiagpath.2019.03.002. PMID: 30921621
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Ovarian clear cell adenocarcinoma.
Kennedy AW, Biscotti CV, Hart WR, Webster KD
Gynecol Oncol 1989 Mar;32(3):342-9. doi: 10.1016/0090-8258(89)90637-9. PMID: 2920955

Recent systematic reviews

Clear cell carcinoma of the ovary and venous thromboembolism: a systematic review and meta-analysis.
Didar H, Farzaneh F, Najafiarab H, Namakin K, Gohari K, Sheidaei A, Ramezani S
Curr Med Res Opin 2023 Jun;39(6):901-910. Epub 2023 May 7 doi: 10.1080/03007995.2023.2208488. PMID: 37104696
Uterine carcinosarcoma vs endometrial serous and clear cell carcinoma: A systematic review and meta-analysis of survival.
Raffone A, Travaglino A, Raimondo D, Maletta M, De Vivo V, Visiello U, Casadio P, Seracchioli R, Zullo F, Insabato L, Mollo A
Int J Gynaecol Obstet 2022 Sep;158(3):520-527. Epub 2021 Dec 11 doi: 10.1002/ijgo.14033. PMID: 34797919Free PMC Article
Clear cell carcinoma of the urinary bladder: a systematic review.
Chan EO, Chan VW, Poon JY, Chan BH, Yu CP, Chiu PK, Ng CF, Teoh JY
Int Urol Nephrol 2021 May;53(5):815-824. Epub 2021 Jan 18 doi: 10.1007/s11255-020-02725-2. PMID: 33462714
Adjuvant chemotherapy vs. observation in stage I clear cell ovarian carcinoma: A systematic review and meta-analysis.
Bogani G, Ditto A, Lopez S, Bertolina F, Murgia F, Pinelli C, Chiappa V, Raspagliesi F
Gynecol Oncol 2020 Apr;157(1):293-298. Epub 2020 Jan 21 doi: 10.1016/j.ygyno.2019.12.045. PMID: 31980220
Systemic therapy for non-clear cell renal cell carcinomas: a systematic review and meta-analysis.
Vera-Badillo FE, Templeton AJ, Duran I, Ocana A, de Gouveia P, Aneja P, Knox JJ, Tannock IF, Escudier B, Amir E
Eur Urol 2015 Apr;67(4):740-9. Epub 2014 Jun 2 doi: 10.1016/j.eururo.2014.05.010. PMID: 24882670

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