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Ovarian Steroid Cell Tumor

MedGen UID:
137756
•Concept ID:
C0334412
•
Neoplastic Process
Synonyms: Lipid Cell Neoplasm of Ovary; Lipid Cell Neoplasm of the Ovary; Lipid cell tumor of ovary; Lipid Cell Tumor of Ovary; Lipid Cell Tumor of the Ovary; Lipoid cell tumor of ovary; Masculinovoblastoma; Ovarian Lipid Cell Neoplasm; Ovarian Lipid Cell Tumor; Ovarian Lipoid Cell Neoplasm; Ovarian Steroid Cell Neoplasm; Steroid cell tumor; Steroid Cell Tumor of Ovary; Steroid Cell Tumor of the Ovary
SNOMED CT: Steroid cell tumor (40761005); Lipid cell tumor of ovary (40761005); Lipoid cell tumor of ovary (40761005); Masculinovoblastoma (40761005)

Definition

An ovarian tumor in which the vast majority of the cells (more than 90% of the tumor cells) resemble steroid hormone-secreting cells. It usually presents with androgenic manifestations. Approximately one-third of the cases follow a malignant clinical course. [from NCI]

Professional guidelines

PubMed

Menopause hormone treatment after cancer.
Gompel A
Climacteric 2023 Jun;26(3):240-247. Epub 2023 Apr 3 doi: 10.1080/13697137.2023.2176216. PMID: 37011657
Clinical Case Seminar: Postmenopausal androgen excess-challenges in diagnostic work-up and management of ovarian thecosis.
Mamoojee Y, Ganguri M, Taylor N, Quinton R
Clin Endocrinol (Oxf) 2018 Jan;88(1):13-20. Epub 2017 Nov 7 doi: 10.1111/cen.13492. PMID: 28980338
The physiology and clinical utility of anti-Mullerian hormone in women.
Dewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, Griesinger G, Kelsey TW, La Marca A, Lambalk C, Mason H, Nelson SM, Visser JA, Wallace WH, Anderson RA
Hum Reprod Update 2014 May-Jun;20(3):370-85. Epub 2014 Jan 14 doi: 10.1093/humupd/dmt062. PMID: 24430863

Recent clinical studies

Etiology

Ovarian steroid cell tumors, not otherwise specified: analysis of nine cases with a literature review.
Lin M, Bao K, Lu L, Xu S, Liang Y, Cheng X, Wang F
BMC Endocr Disord 2022 Nov 1;22(1):265. doi: 10.1186/s12902-022-01170-9. PMID: 36316664Free PMC Article
Ovarian steroid cell tumor causing isosexual pseudoprecocious puberty in a young girl: an instructive case and literature review.
Chu CH, Wang WD, Wang SY, Chao TK, Su RY, Lin CM
BMC Endocr Disord 2022 Feb 16;22(1):41. doi: 10.1186/s12902-022-00956-1. PMID: 35172804Free PMC Article
Ovarian steroid cell tumor, not otherwise specified: a clinicopathological and immunohistochemical experience of 12 cases.
Haroon S, Idrees R, Fatima S, Memon A, Kayani N
J Obstet Gynaecol Res 2015 Mar;41(3):424-31. Epub 2014 Oct 27 doi: 10.1111/jog.12537. PMID: 25345475

Diagnosis

Hypoxia-associated genetic signature in ovarian steroid cell tumor NOS.
Chao A, Huang HJ, Lin CY, Lee CH, Lin CH, Chao AS, Lai CH, Chang TC, Wu KY, Wu RC
Endocr Relat Cancer 2023 Nov 1;30(11) Epub 2023 Oct 4 doi: 10.1530/ERC-23-0179. PMID: 37655726
Ovarian Sex Cord Stromal Tumor, Steroid Cell, NOS in an Adolescent: A Case Report.
Schnuckle EM, Williamson A, Carpentieri D, Taylor S
J Pediatr Adolesc Gynecol 2021 Feb;34(1):94-97. Epub 2020 Aug 8 doi: 10.1016/j.jpag.2020.08.001. PMID: 32781238
Case of ovarian steroid cell tumor diagnosed after presenting acute heart failure.
Matsuda S, Yamaguchi Y, Kaseki H, Watanabe K, Ono S, Yamamoto A, Ichikawa M, Akira S, Takeshita T
J Obstet Gynaecol Res 2020 Jul;46(7):1211-1215. Epub 2020 May 27 doi: 10.1111/jog.14339. PMID: 32462709
Ovarian steroid cell tumor, not otherwise specified, producing testosterone.
Mizoguchi M, Minami S, Yamamoto M, Tanizaki Y, Kobayashi A, Ino K
J Obstet Gynaecol Res 2014 Sep;40(9):2081-5. doi: 10.1111/jog.12467. PMID: 25181629
Ovarian steroid cell tumor, not otherwise specified, associated with congenital adrenal hyperplasia: rare tumors of an endocrine disease.
Thomas TT, Ruscher KR, Mandavilli S, Balarezo F, Finck CM
J Pediatr Surg 2013 Jun;48(6):E23-7. doi: 10.1016/j.jpedsurg.2013.04.006. PMID: 23845653

Therapy

Bilateral ovarian steroid cell tumor in congenital adrenal hyperplasia due to classic 11beta-hydroxylase deficiency.
Baş F, Saka N, Darendeliler F, Tuzlali S, Ilhan R, Bundak R, Günöz H
J Pediatr Endocrinol Metab 2000 Jun;13(6):663-7. doi: 10.1515/jpem.2000.13.6.663. PMID: 10905393

Prognosis

Ovarian steroid cell tumors, not otherwise specified: analysis of nine cases with a literature review.
Lin M, Bao K, Lu L, Xu S, Liang Y, Cheng X, Wang F
BMC Endocr Disord 2022 Nov 1;22(1):265. doi: 10.1186/s12902-022-01170-9. PMID: 36316664Free PMC Article
Failure of multiple surgical procedures and adjuvant chemotherapy in early-stage steroid-cell ovarian tumor treatment: a case report and literature review.
Vasilevska D, Rudaitis V, Vasilevska D, Mickys U, Wawrysiuk S, Semczuk A
J Int Med Res 2021 Jan;49(1):300060520983195. doi: 10.1177/0300060520983195. PMID: 33435776Free PMC Article
Cytological Findings of Ascitic Fluid with a Malignant Ovarian Steroid Cell Tumor: A Case Report and Literature Review.
Kosaka N, Hasegawa K, Kiuchi K, Ochiai S, Nagai T, Machida H, Imai Y, Fukasawa I
Acta Cytol 2017;61(2):165-171. Epub 2017 Mar 25 doi: 10.1159/000458750. PMID: 28343229
Vaginal bleeding and galactorrhea in a child with ovarian steroid cell tumor.
Ashraf A, Abdul-Latif H, Hardin W, Kelly DB
Endocr Pract 2005 Sep-Oct;11(5):346-9. doi: 10.4158/EP.11.5.346. PMID: 16191497
Ectopic ACTH syndrome associated with ovarian steroid-cell tumor.
Sworczak K, Blaut K, Malecha M, Lewczuk A
J Endocrinol Invest 2002 Apr;25(4):369-72. doi: 10.1007/BF03344020. PMID: 12030610

Clinical prediction guides

A Report of a Case With Pediatric Ovarian Steroid Cell Tumor, Not Otherwise Specified, Found With Precocious Puberty.
Umeda S, Takase K, Takayama K, Yamamichi T, Higuchi K, Kawai M, Takeuchi M, Inoue M, Usui N
J Pediatr Hematol Oncol 2023 May 1;45(4):e522-e524. Epub 2022 Jun 7 doi: 10.1097/MPH.0000000000002496. PMID: 35700385
Ovarian steroid cell tumors, not otherwise specified: analysis of nine cases with a literature review.
Lin M, Bao K, Lu L, Xu S, Liang Y, Cheng X, Wang F
BMC Endocr Disord 2022 Nov 1;22(1):265. doi: 10.1186/s12902-022-01170-9. PMID: 36316664Free PMC Article
Successful laparoscopic resection of virilizing ovarian steroid cell tumor, not otherwise specified, in a 22-year-old woman: a case report and evaluation of the steroidogenic pathway.
Matsukawa J, Takahashi T, Hada Y, Kameda W, Ota K, Fukase M, Takahashi K, Matsuo K, Mizunuma H, Nagase S
Fukushima J Med Sci 2020 Jan 9;65(3):133-139. Epub 2019 Dec 11 doi: 10.5387/fms.2019-25. PMID: 31827013Free PMC Article
Cytological Findings of Ascitic Fluid with a Malignant Ovarian Steroid Cell Tumor: A Case Report and Literature Review.
Kosaka N, Hasegawa K, Kiuchi K, Ochiai S, Nagai T, Machida H, Imai Y, Fukasawa I
Acta Cytol 2017;61(2):165-171. Epub 2017 Mar 25 doi: 10.1159/000458750. PMID: 28343229
Ovarian steroid cell tumor, not otherwise specified: a clinicopathological and immunohistochemical experience of 12 cases.
Haroon S, Idrees R, Fatima S, Memon A, Kayani N
J Obstet Gynaecol Res 2015 Mar;41(3):424-31. Epub 2014 Oct 27 doi: 10.1111/jog.12537. PMID: 25345475

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