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Well Differentiated Ovarian Steroid Cell Tumor

MedGen UID:
274422
•Concept ID:
C1520133
•
Neoplastic Process

Definition

An ovarian steroid cell tumor not otherwise specified, and characterized by the absence of nuclear atypia, mitotic figures, necrosis, and hemorrhage. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWell Differentiated Ovarian Steroid Cell Tumor

Professional guidelines

PubMed

Clinical Case Seminar: Postmenopausal androgen excess-challenges in diagnostic work-up and management of ovarian thecosis.
Mamoojee Y, Ganguri M, Taylor N, Quinton R
Clin Endocrinol (Oxf) 2018 Jan;88(1):13-20. Epub 2017 Nov 7 doi: 10.1111/cen.13492. PMID: 28980338
Differential diagnosis of abnormal uterine bleeding.
Brenner PF
Am J Obstet Gynecol 1996 Sep;175(3 Pt 2):766-9. doi: 10.1016/s0002-9378(96)80082-2. PMID: 8828559
Assessment of electric differential treatment (EDiT) and Endosan treatment for ovarian cysts and concomitant symptoms.
Savery F, Silver F, Edward R, Fann A, Mann R, Rogers C, May HU, Sorgnard R
Adv Ther 1991 Sep-Oct;8(5):243-9. PMID: 10150046

Recent clinical studies

Etiology

Ovarian Leydig Cell Tumor and Ovarian Hyperthecosis in a Postmenopausal Woman: A Case Report and Literature Review.
Bužinskienė D, Marčiukaitytė R, Šidlovska E, Rudaitis V
Medicina (Kaunas) 2023 Jun 6;59(6) doi: 10.3390/medicina59061097. PMID: 37374301Free PMC Article
Genomic classification of benign adrenocortical lesions.
Faillot S, Foulonneau T, Néou M, Espiard S, Garinet S, Vaczlavik A, Jouinot A, Rondof W, Septier A, Drougat L, Hécale-Perlemoine K, Ragazzon B, Rizk-Rabin M, Sibony M, Bonnet-Serrano F, Guibourdenche J, Libé R, Groussin L, Dousset B, de Reyniès A, Bertherat J, Assié G
Endocr Relat Cancer 2021 Jan;28(1):79-95. doi: 10.1530/ERC-20-0128. PMID: 33151900
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Effect of steroid hormones, estrogen and progesterone, on epithelial mesenchymal transition in ovarian cancer development.
Jeon SY, Hwang KA, Choi KC
J Steroid Biochem Mol Biol 2016 Apr;158:1-8. Epub 2016 Feb 9 doi: 10.1016/j.jsbmb.2016.02.005. PMID: 26873134
Vitamin D and cancer.
Ali MM, Vaidya V
J Cancer Res Ther 2007 Oct-Dec;3(4):225-30. doi: 10.4103/0973-1482.38998. PMID: 18270398

Diagnosis

Ovarian Leydig Cell Tumor and Ovarian Hyperthecosis in a Postmenopausal Woman: A Case Report and Literature Review.
Bužinskienė D, Marčiukaitytė R, Šidlovska E, Rudaitis V
Medicina (Kaunas) 2023 Jun 6;59(6) doi: 10.3390/medicina59061097. PMID: 37374301Free PMC Article
Hyperthecosis: an underestimated nontumorous cause of hyperandrogenism.
Meczekalski B, Szeliga A, Maciejewska-Jeske M, Podfigurna A, Cornetti P, Bala G, Adashi EY
Gynecol Endocrinol 2021 Aug;37(8):677-682. Epub 2021 Mar 24 doi: 10.1080/09513590.2021.1903419. PMID: 33759685
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Clinical Case Seminar: Postmenopausal androgen excess-challenges in diagnostic work-up and management of ovarian thecosis.
Mamoojee Y, Ganguri M, Taylor N, Quinton R
Clin Endocrinol (Oxf) 2018 Jan;88(1):13-20. Epub 2017 Nov 7 doi: 10.1111/cen.13492. PMID: 28980338
Calcium, vitamin D and cancer.
Peterlik M, Grant WB, Cross HS
Anticancer Res 2009 Sep;29(9):3687-98. PMID: 19667166

Therapy

Diabetes mellitus and gynecologic cancer: molecular mechanisms, epidemiological, clinical and prognostic perspectives.
Vrachnis N, Iavazzo C, Iliodromiti Z, Sifakis S, Alexandrou A, Siristatidis C, Grigoriadis C, Botsis D, Creatsas G
Arch Gynecol Obstet 2016 Feb;293(2):239-46. Epub 2015 Sep 4 doi: 10.1007/s00404-015-3858-z. PMID: 26338721
Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications.
Moravek MB, Yin P, Ono M, Coon JS 5th, Dyson MT, Navarro A, Marsh EE, Chakravarti D, Kim JJ, Wei JJ, Bulun SE
Hum Reprod Update 2015 Jan-Feb;21(1):1-12. Epub 2014 Sep 8 doi: 10.1093/humupd/dmu048. PMID: 25205766Free PMC Article
Health outcomes of vitamin D. Part II. Role in prevention of diseases.
Wranicz J, Szostak-Węgierek D
Rocz Panstw Zakl Hig 2014;65(4):273-9. PMID: 25526571
Calcium, vitamin D and cancer.
Peterlik M, Grant WB, Cross HS
Anticancer Res 2009 Sep;29(9):3687-98. PMID: 19667166
Progesterone antagonists: tumor-inhibiting potential and mechanism of action.
Michna H, Nishino Y, Neef G, McGuire WL, Schneider MR
J Steroid Biochem Mol Biol 1992 Mar;41(3-8):339-48. doi: 10.1016/0960-0760(92)90360-u. PMID: 1562510

Prognosis

Ovarian Leydig Cell Tumor and Ovarian Hyperthecosis in a Postmenopausal Woman: A Case Report and Literature Review.
Bužinskienė D, Marčiukaitytė R, Šidlovska E, Rudaitis V
Medicina (Kaunas) 2023 Jun 6;59(6) doi: 10.3390/medicina59061097. PMID: 37374301Free PMC Article
Effect of 1α,25(OH)(2)D(3)-Treated M1 and M2 Macrophages on Cell Proliferation and Migration Ability in Ovarian Cancer.
Guo Y, Jiang F, Yang W, Shi W, Wan J, Li J, Pan J, Wang P, Qiu J, Zhang Z, Li B
Nutr Cancer 2022;74(7):2632-2643. Epub 2021 Dec 13 doi: 10.1080/01635581.2021.2014903. PMID: 34894920
Clinicopathologic Characterization of GREB1-rearranged Uterine Sarcomas With Variable Sex-Cord Differentiation.
Lee CH, Kao YC, Lee WR, Hsiao YW, Lu TP, Chu CY, Lin YJ, Huang HY, Hsieh TH, Liu YR, Liang CW, Chen TW, Yip S, Lum A, Kuo KT, Jeng YM, Yu SC, Chung YC, Lee JC
Am J Surg Pathol 2019 Jul;43(7):928-942. doi: 10.1097/PAS.0000000000001265. PMID: 31094921
Diabetes mellitus and gynecologic cancer: molecular mechanisms, epidemiological, clinical and prognostic perspectives.
Vrachnis N, Iavazzo C, Iliodromiti Z, Sifakis S, Alexandrou A, Siristatidis C, Grigoriadis C, Botsis D, Creatsas G
Arch Gynecol Obstet 2016 Feb;293(2):239-46. Epub 2015 Sep 4 doi: 10.1007/s00404-015-3858-z. PMID: 26338721
Progesterone antagonists: tumor-inhibiting potential and mechanism of action.
Michna H, Nishino Y, Neef G, McGuire WL, Schneider MR
J Steroid Biochem Mol Biol 1992 Mar;41(3-8):339-48. doi: 10.1016/0960-0760(92)90360-u. PMID: 1562510

Clinical prediction guides

Upregulated let-7 expression in the follicular fluid of patients with endometriomas leads to dysfunction of granulosa cells through targeting of IGF1R.
Shi L, Ying H, Dai Y, Rong Y, Chen J, Zhou F, Wang S, Xu S, Tong X, Zhang S
Hum Reprod 2025 Jan 1;40(1):119-137. doi: 10.1093/humrep/deae247. PMID: 39521729Free PMC Article
Effect of 1α,25(OH)(2)D(3)-Treated M1 and M2 Macrophages on Cell Proliferation and Migration Ability in Ovarian Cancer.
Guo Y, Jiang F, Yang W, Shi W, Wan J, Li J, Pan J, Wang P, Qiu J, Zhang Z, Li B
Nutr Cancer 2022;74(7):2632-2643. Epub 2021 Dec 13 doi: 10.1080/01635581.2021.2014903. PMID: 34894920
Insights into molecular pathways of endometriosis and endometriosis-related ovarian carcinoma.
Păvăleanu I, Lozneanu L, Balan RA, Giuşcă SE, Avădănei ER, Căruntu ID, Amălinei C
Rom J Morphol Embryol 2020 Jul-Sep;61(3):739-749. doi: 10.47162/RJME.61.3.12. PMID: 33817715Free PMC Article
Health outcomes of vitamin D. Part II. Role in prevention of diseases.
Wranicz J, Szostak-Węgierek D
Rocz Panstw Zakl Hig 2014;65(4):273-9. PMID: 25526571
Progesterone antagonists: tumor-inhibiting potential and mechanism of action.
Michna H, Nishino Y, Neef G, McGuire WL, Schneider MR
J Steroid Biochem Mol Biol 1992 Mar;41(3-8):339-48. doi: 10.1016/0960-0760(92)90360-u. PMID: 1562510

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