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Malignant struma ovarii

MedGen UID:
137777
•Concept ID:
C0334525
•
Neoplastic Process
Synonyms: Malignant Struma Ovarii; malignant struma ovarii; Struma ovarii, malignant; struma ovarii, malignant; struma ovarii, malignant (morphologic abnormality); Thyroid Carcinoma Arising in Struma Ovarii
SNOMED CT: Malignant struma ovarii (18854008); Struma ovarii, malignant (18854008)
 
Monarch Initiative: MONDO:0003332

Definition

A carcinoma with histological features identical to thyroid carcinoma, arising in ovarian mature teratoma with aberrant thyroid tissue (struma ovarii). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant struma ovarii

Recent clinical studies

Etiology

Clinical characteristics and survival outcomes of malignant struma ovarii confined to the ovary.
Li S, Yang T, Xiang Y, Li X, Zhang L, Deng S
BMC Cancer 2021 Apr 9;21(1):383. doi: 10.1186/s12885-021-08118-7. PMID: 33836675Free PMC Article
Malignant struma ovarii: surgical, histopathological and survival outcomes for thyroid-type carcinoma of struma ovarii with recommendations for standardising multi-modal management. A retrospective case series sharing the experience of a single institution over 10 years.
Addley S, Mihai R, Alazzam M, Dhar S, Soleymani Majd H
Arch Gynecol Obstet 2021 Apr;303(4):863-870. Epub 2021 Jan 29 doi: 10.1007/s00404-021-05969-0. PMID: 33512594
Complete response of recurrent malignant struma ovarii followed by (131)I therapy.
Tang J, Hao P, Zhu W, Hu J, Wen H
J Obstet Gynaecol 2021 Jan;41(1):152-154. Epub 2020 Jun 9 doi: 10.1080/01443615.2019.1650258. PMID: 32515669
Struma ovarii.
Ayhan A, Yanik F, Tuncer R, Tuncer ZS, Ruacan S
Int J Gynaecol Obstet 1993 Aug;42(2):143-6. doi: 10.1016/0020-7292(93)90628-a. PMID: 7901063
Malignant struma ovarii.
de Graaff J, van Vliet MA, Misereé J
Eur J Obstet Gynecol Reprod Biol 1983 Sep;16(1):31-5. doi: 10.1016/0028-2243(83)90217-4. PMID: 6628817

Diagnosis

Malignant struma ovarii: surgical, histopathological and survival outcomes for thyroid-type carcinoma of struma ovarii with recommendations for standardising multi-modal management. A retrospective case series sharing the experience of a single institution over 10 years.
Addley S, Mihai R, Alazzam M, Dhar S, Soleymani Majd H
Arch Gynecol Obstet 2021 Apr;303(4):863-870. Epub 2021 Jan 29 doi: 10.1007/s00404-021-05969-0. PMID: 33512594
Metastatic malignant struma ovarii: Two scenarios of the same pathology.
Ernaga Lorea A, Hernández Morhain MC, Anda Apiñániz E, Lapeña Calavia S, Eguílaz Esparza N
Endocrinol Diabetes Nutr 2017 Feb;64(2):121-122. Epub 2017 Feb 1 doi: 10.1016/j.endinu.2016.09.008. PMID: 28440778
Sincronous malignant struma ovarii and papillary thyroid carcinoma.
Fernández Catalina P, Rego Iraeta A, Lorenzo Solar M, Sánchez Sobrino P
Endocrinol Nutr 2016 Aug-Sep;63(7):366-7. Epub 2016 Jun 11 doi: 10.1016/j.endonu.2016.05.002. PMID: 27297016
Struma ovarii.
Ayhan A, Yanik F, Tuncer R, Tuncer ZS, Ruacan S
Int J Gynaecol Obstet 1993 Aug;42(2):143-6. doi: 10.1016/0020-7292(93)90628-a. PMID: 7901063
Malignant struma ovarii.
de Graaff J, van Vliet MA, Misereé J
Eur J Obstet Gynecol Reprod Biol 1983 Sep;16(1):31-5. doi: 10.1016/0028-2243(83)90217-4. PMID: 6628817

Therapy

Malignant struma ovarii: From case to analysis.
Ayhan S, Kilic F, Ersak B, Aytekin O, Akar S, Turkmen O, Akgul G, Toyran A, Turan T, Kimyon Comert G
J Obstet Gynaecol Res 2021 Sep;47(9):3339-3351. Epub 2021 Jul 4 doi: 10.1111/jog.14902. PMID: 34219334
Complete response of recurrent malignant struma ovarii followed by (131)I therapy.
Tang J, Hao P, Zhu W, Hu J, Wen H
J Obstet Gynaecol 2021 Jan;41(1):152-154. Epub 2020 Jun 9 doi: 10.1080/01443615.2019.1650258. PMID: 32515669
Metastatic malignant struma ovarii: Two scenarios of the same pathology.
Ernaga Lorea A, Hernández Morhain MC, Anda Apiñániz E, Lapeña Calavia S, Eguílaz Esparza N
Endocrinol Diabetes Nutr 2017 Feb;64(2):121-122. Epub 2017 Feb 1 doi: 10.1016/j.endinu.2016.09.008. PMID: 28440778
Sincronous malignant struma ovarii and papillary thyroid carcinoma.
Fernández Catalina P, Rego Iraeta A, Lorenzo Solar M, Sánchez Sobrino P
Endocrinol Nutr 2016 Aug-Sep;63(7):366-7. Epub 2016 Jun 11 doi: 10.1016/j.endonu.2016.05.002. PMID: 27297016
Malignant struma ovarii: presentation and management.
O'Connell ME, Fisher C, Harmer CL
Br J Radiol 1990 May;63(749):360-3. doi: 10.1259/0007-1285-63-749-360. PMID: 2379061

Prognosis

Malignant struma ovarii: From case to analysis.
Ayhan S, Kilic F, Ersak B, Aytekin O, Akar S, Turkmen O, Akgul G, Toyran A, Turan T, Kimyon Comert G
J Obstet Gynaecol Res 2021 Sep;47(9):3339-3351. Epub 2021 Jul 4 doi: 10.1111/jog.14902. PMID: 34219334
Malignant struma ovarii: surgical, histopathological and survival outcomes for thyroid-type carcinoma of struma ovarii with recommendations for standardising multi-modal management. A retrospective case series sharing the experience of a single institution over 10 years.
Addley S, Mihai R, Alazzam M, Dhar S, Soleymani Majd H
Arch Gynecol Obstet 2021 Apr;303(4):863-870. Epub 2021 Jan 29 doi: 10.1007/s00404-021-05969-0. PMID: 33512594
Complete response of recurrent malignant struma ovarii followed by (131)I therapy.
Tang J, Hao P, Zhu W, Hu J, Wen H
J Obstet Gynaecol 2021 Jan;41(1):152-154. Epub 2020 Jun 9 doi: 10.1080/01443615.2019.1650258. PMID: 32515669
Metastatic malignant struma ovarii: Two scenarios of the same pathology.
Ernaga Lorea A, Hernández Morhain MC, Anda Apiñániz E, Lapeña Calavia S, Eguílaz Esparza N
Endocrinol Diabetes Nutr 2017 Feb;64(2):121-122. Epub 2017 Feb 1 doi: 10.1016/j.endinu.2016.09.008. PMID: 28440778
Malignant struma ovarii.
de Graaff J, van Vliet MA, Misereé J
Eur J Obstet Gynecol Reprod Biol 1983 Sep;16(1):31-5. doi: 10.1016/0028-2243(83)90217-4. PMID: 6628817

Clinical prediction guides

Personalized approach to malignant struma ovarii: Insights from a web-based machine learning tool.
Alshwayyat S, Abo-Elnour DE, Dabash TY, Alshwayyat TA, Alabbasi M, Alshwayyat M, Irsheidat KA
Int J Gynaecol Obstet 2025 Jan;168(1):343-352. Epub 2024 Aug 4 doi: 10.1002/ijgo.15845. PMID: 39099297
Clinical Manifestations of Malignant Struma Ovarii: A Retrospective Case Series in a Tertiary Hospital in Korea.
Ryu HJ, Leem DE, Yoo JH, Kim TH, Kim SW, Chung JH
Endocrinol Metab (Seoul) 2024 Jun;39(3):461-467. Epub 2024 May 9 doi: 10.3803/EnM.2023.1863. PMID: 38721636Free PMC Article
A rare case of highly differentiated follicular carcinoma in ovary with FGFR4 Gly388Arg polymorphism: a case report and literature review.
Bao YT, Wang C, Huang W, Yao LQ, Yuan L
J Ovarian Res 2022 Jun 14;15(1):71. doi: 10.1186/s13048-022-01007-y. PMID: 35701820Free PMC Article
Late Manifestation of Struma Peritonei and Widespread Functioning Lesions in the Setting of Struma Ovarii Simulating Highly Differentiated Follicular Carcinoma.
Ranade R, Rachh S, Basu S
J Nucl Med Technol 2015 Sep;43(3):231-3. Epub 2014 Dec 23 doi: 10.2967/jnmt.114.149294. PMID: 25537757
Malignant struma ovarii: a population-level analysis of a large series of 68 patients.
Goffredo P, Sawka AM, Pura J, Adam MA, Roman SA, Sosa JA
Thyroid 2015 Feb;25(2):211-5. Epub 2014 Dec 5 doi: 10.1089/thy.2014.0328. PMID: 25375817

Recent systematic reviews

Malignant struma ovarii: From case to analysis.
Ayhan S, Kilic F, Ersak B, Aytekin O, Akar S, Turkmen O, Akgul G, Toyran A, Turan T, Kimyon Comert G
J Obstet Gynaecol Res 2021 Sep;47(9):3339-3351. Epub 2021 Jul 4 doi: 10.1111/jog.14902. PMID: 34219334

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