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Charles bonnet syndrome

MedGen UID:
137926
Concept ID:
C0339731
Disease or Syndrome
Synonym: Charles Bonnet Syndrome
SNOMED CT: Charles Bonnet syndrome (193756007)
 
Monarch Initiative: MONDO:0022140

Definition

Charles Bonnet syndrome (CBS) refers to the presenceof visual hallucinations in individuals with visual acuity loss without havingpsychosis or dementia. The condition is likely caused by the brain continuing to interpret images, even in their absence. Underlying conditions of vision loss associated with Charles Bonnet syndrome are diverse (including conditions such as macular degeneration and stroke) and may affect the eye, optic nerve, or brain. Hallucinations often resolve if the underlying vision deficit is corrected and can also remit in some individuals with static or progressive vision loss. Treatment is individualized. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCharles bonnet syndrome

Professional guidelines

PubMed

Eren OE, Wilhelm H, Schankin CJ, Straube A
Dtsch Arztebl Int 2021 Oct 1;118(39):647-653. doi: 10.3238/arztebl.m2021.0287. PMID: 34636719Free PMC Article
Santos-Bueso E, Porta-Etessam J
Arch Soc Esp Oftalmol 2016 Nov;91(11):511-512. Epub 2016 Aug 16 doi: 10.1016/j.oftal.2016.07.005. PMID: 27542522
Singh A, Sørensen TL
Br J Ophthalmol 2011 Feb;95(2):291-2. Epub 2010 Aug 23 doi: 10.1136/bjo.2010.179465. PMID: 20733019

Recent clinical studies

Etiology

Collerton D, Barnes J, Diederich NJ, Dudley R, Ffytche D, Friston K, Goetz CG, Goldman JG, Jardri R, Kulisevsky J, Lewis SJG, Nara S, O'Callaghan C, Onofrj M, Pagonabarraga J, Parr T, Shine JM, Stebbins G, Taylor JP, Tsuda I, Weil RS
Neurosci Biobehav Rev 2023 Jul;150:105208. Epub 2023 May 2 doi: 10.1016/j.neubiorev.2023.105208. PMID: 37141962
Le JT, Peprah D, Agrón E, Keenan TDL, Clemons TE, Chew EY; Age-Related Eye Disease Study 2 Research Group
Ophthalmology 2022 Feb;129(2):233-235. Epub 2021 Aug 20 doi: 10.1016/j.ophtha.2021.08.012. PMID: 34419554Free PMC Article
Satgunam P, Sumalini R, Chittapu G, Pamarthi G
Indian J Ophthalmol 2019 Jul;67(7):1127-1132. doi: 10.4103/ijo.IJO_1533_18. PMID: 31238427Free PMC Article
Schneider MA, Schneider MD
Nursing 2013 Jul;43(7):52-5. doi: 10.1097/01.NURSE.0000427989.23941.18. PMID: 23778216
Evers S
Curr Psychiatry Rep 2006 Jun;8(3):205-10. doi: 10.1007/s11920-006-0024-0. PMID: 19817070

Diagnosis

Risi E, Bagla P, Allen L, Das A
Prim Care Companion CNS Disord 2023 Nov 9;25(6) doi: 10.4088/PCC.23cr03545. PMID: 37976227
Mansuri Z, Patel K, Shah B, Trivedi C, Adnan M, Vadukapuram R, Zafar MK, Makani R, Reddy A
J Nerv Ment Dis 2022 Nov 1;210(11):880-882. doi: 10.1097/NMD.0000000000001523. PMID: 36302083
Huang JJM, Jiang IW, Khan MA, Lin M, Trang E, Wong ELS, Selby A, Iyer A, Evens T, Pitman AG, Dawes LC, Agar A, Francis IC
J Neuroophthalmol 2022 Mar 1;42(1):e420-e422. Epub 2021 Apr 14 doi: 10.1097/WNO.0000000000001206. PMID: 33870935
Santos-Bueso E, Porta-Etessam J
Arch Soc Esp Oftalmol 2016 Nov;91(11):511-512. Epub 2016 Aug 16 doi: 10.1016/j.oftal.2016.07.005. PMID: 27542522
Cammaroto S, D'Aleo G, Smorto C, Bramanti P
Funct Neurol 2008 Jul-Sep;23(3):123-7. PMID: 19152731

Therapy

Risi E, Bagla P, Allen L, Das A
Prim Care Companion CNS Disord 2023 Nov 9;25(6) doi: 10.4088/PCC.23cr03545. PMID: 37976227
Boren RA, Boren CB
J Neuroophthalmol 2019 Dec;39(4):500-501. doi: 10.1097/WNO.0000000000000800. PMID: 31022063
Cammaroto S, D'Aleo G, Smorto C, Bramanti P
Funct Neurol 2008 Jul-Sep;23(3):123-7. PMID: 19152731
Bhatia MS, Khastgir U, Malik SC
Br J Psychiatry 1992 Sep;161:409-10. doi: 10.1192/bjp.161.3.409. PMID: 1393314
Olbrich HM, Engelmeier MP, Pauleikhoff D, Waubke T
Graefes Arch Clin Exp Ophthalmol 1987;225(3):217-20. doi: 10.1007/BF02175452. PMID: 3609761

Prognosis

Christoph SEG, Boden KT, Pütz A, Januschowski K, Siegel R, Seitz B, Szurman P, Schulz A
Int Ophthalmol 2024 Sep 10;44(1):375. doi: 10.1007/s10792-024-03298-0. PMID: 39256212Free PMC Article
Carpenter K, Jolly JK, Bridge H
Ophthalmic Physiol Opt 2019 Nov;39(6):414-421. Epub 2019 Oct 8 doi: 10.1111/opo.12645. PMID: 31591762
Satgunam P, Sumalini R, Chittapu G, Pamarthi G
Indian J Ophthalmol 2019 Jul;67(7):1127-1132. doi: 10.4103/ijo.IJO_1533_18. PMID: 31238427Free PMC Article
Stojanov O
Vojnosanit Pregl 2016 Sep;73(9):881-4. doi: 10.2298/VSP150321140S. PMID: 29320624
Olbrich HM, Engelmeier MP, Pauleikhoff D, Waubke T
Graefes Arch Clin Exp Ophthalmol 1987;225(3):217-20. doi: 10.1007/BF02175452. PMID: 3609761

Clinical prediction guides

Dhooge PPA, Teunisse RJ, Liefers B, Lambertus S, Bax NM, Hoyng CB, Cruysberg JRM, Klevering BJ
Br J Ophthalmol 2023 Feb;107(2):248-253. Epub 2021 Aug 4 doi: 10.1136/bjophthalmol-2021-319525. PMID: 34348923
Firbank MJ, daSilva Morgan K, Collerton D, Elder GJ, Parikh J, Olsen K, Schumacher J, Ffytche D, Taylor JP
Neuroimage Clin 2022;35:103041. Epub 2022 May 11 doi: 10.1016/j.nicl.2022.103041. PMID: 35576854Free PMC Article
Stojanov O
Vojnosanit Pregl 2016 Sep;73(9):881-4. doi: 10.2298/VSP150321140S. PMID: 29320624
Ashwin PT, Tsaloumas MD
J Neurol Sci 2007 Dec 15;263(1-2):184-6. Epub 2007 Jun 22 doi: 10.1016/j.jns.2007.05.027. PMID: 17588608
Batra A, Bartels M, Wormstall H
Acta Psychiatr Scand 1997 Aug;96(2):129-33. doi: 10.1111/j.1600-0447.1997.tb09917.x. PMID: 9272197

Recent systematic reviews

Blom JD
Neurosci Biobehav Rev 2021 Jun;125:627-636. Epub 2021 Mar 4 doi: 10.1016/j.neubiorev.2021.03.002. PMID: 33676962
Subhi Y, Schmidt DC, Bach-Holm D, Kolko M, Singh A
Acta Ophthalmol 2021 Mar;99(2):128-133. Epub 2020 Aug 4 doi: 10.1111/aos.14567. PMID: 32749787
Niazi S, Krogh Nielsen M, Singh A, Sørensen TL, Subhi Y
Acta Ophthalmol 2020 Mar;98(2):121-131. Epub 2019 Oct 26 doi: 10.1111/aos.14287. PMID: 31654492
Russell G, Burns A
Int Psychogeriatr 2014 Sep;26(9):1431-1443. doi: 10.1017/S1041610214000763. PMID: 24848082

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