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Abnormal vestibular saccule morphology

MedGen UID:
1384115
•Concept ID:
C4476902
•
Anatomical Abnormality
Synonyms: Abnormal saccule morphology; Morphological abnormality of the saccule
 
HPO: HP:0030999

Definition

Any structural anomaly of the saccule of the vestibule. The saccule is the otolith organ that senses motions in the sagittal plane (i.e., up-down movement). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal vestibular saccule morphology

Recent clinical studies

Etiology

Relationship between vestibular schwannoma and endolymphatic hydrops.
Meng LC, Lin KT, Young YH
J Formos Med Assoc 2024 Nov;123(11):1149-1153. Epub 2024 Jun 21 doi: 10.1016/j.jfma.2024.06.014. PMID: 38906730
Peripheral vestibular pathology in Mondini dysplasia.
Kaya S, Hızlı Ö, Kaya FK, Monsanto RD, Paparella MM, Cureoglu S
Laryngoscope 2017 Jan;127(1):206-209. Epub 2016 Apr 14 doi: 10.1002/lary.25995. PMID: 27075694
Acoustically evoked short latency negative responses in hearing loss patients with enlarged vestibular aqueduct.
Liu L, Yang B
Acta Neurol Belg 2013 Jun;113(2):157-60. Epub 2012 Oct 2 doi: 10.1007/s13760-012-0138-6. PMID: 23055113
Vestibular evoked myogenic potential latencies in Meniere disease and vestibular schwannoma.
Beyea JA, Zeitouni AG
J Otolaryngol Head Neck Surg 2010 Jun;39(3):253-8. PMID: 20470669
Behavioural changes in hamsters with otoconial malformations.
Sondag HN, de Jong HA, van Marle J, Oosterveld WJ
Acta Otolaryngol 1998 Jan;118(1):86-9. doi: 10.1080/00016489850155189. PMID: 9504169

Diagnosis

Vestibular Impairment in Hemifacial Spasm Syndrome: A Case Report.
Barona L, Krstulovic C, Bejarano B, Perez N
J Int Adv Otol 2020 Apr;16(1):138-140. doi: 10.5152/iao.2020.6112. PMID: 32209525Free PMC Article
Cerebellar contributions to self-motion perception: evidence from patients with congenital cerebellar agenesis.
Dahlem K, Valko Y, Schmahmann JD, Lewis RF
J Neurophysiol 2016 May 1;115(5):2280-5. Epub 2016 Feb 17 doi: 10.1152/jn.00763.2015. PMID: 26888100Free PMC Article
Acoustically evoked short latency negative responses in hearing loss patients with enlarged vestibular aqueduct.
Liu L, Yang B
Acta Neurol Belg 2013 Jun;113(2):157-60. Epub 2012 Oct 2 doi: 10.1007/s13760-012-0138-6. PMID: 23055113
The otolithic organ as a receptor of vestibular hearing revealed by vestibular-evoked myogenic potentials in patients with inner ear anomalies.
Sheykholeslami K, Kaga K
Hear Res 2002 Mar;165(1-2):62-7. doi: 10.1016/s0378-5955(02)00278-2. PMID: 12031516
Torsional vestibulo-ocular reflex measurements for identifying otolith asymmetries possibly related to space motion sickness susceptibility.
Peterka RJ
Acta Astronaut 1994 Jul;33:1-8. doi: 10.1016/0094-5765(94)90101-5. PMID: 11539508

Therapy

Head-shaking aids in the diagnosis of acute audiovestibular loss due to anterior inferior cerebellar artery infarction.
Huh YE, Koo JW, Lee H, Kim JS
Audiol Neurootol 2013;18(2):114-24. Epub 2012 Dec 28 doi: 10.1159/000345643. PMID: 23296146
Vestibular evoked myogenic potentials in acute acoustic trauma.
Wang YP, Hsu WC, Young YH
Otol Neurotol 2006 Oct;27(7):956-61. doi: 10.1097/01.mao.0000231590.57348.4b. PMID: 17006346
Effect of conductive hearing loss on the vestibulo-collic reflex.
Bath AP, Harris N, McEwan J, Yardley MP
Clin Otolaryngol Allied Sci 1999 Jun;24(3):181-3. doi: 10.1046/j.1365-2273.1999.00234.x. PMID: 10384842
Torsional vestibulo-ocular reflex measurements for identifying otolith asymmetries possibly related to space motion sickness susceptibility.
Peterka RJ
Acta Astronaut 1994 Jul;33:1-8. doi: 10.1016/0094-5765(94)90101-5. PMID: 11539508
Experimental pathogenesis of hydrops.
Kimura RS
Arch Otorhinolaryngol 1976 Sep 16;212(4):263-75. doi: 10.1007/BF00453674. PMID: 990078

Prognosis

Assessing the optimal MRI descriptors to diagnose Ménière's disease and the added value of analysing the vestibular aqueduct.
Connor S, Pai I, Touska P, McElroy S, Ourselin S, Hajnal JV
Eur Radiol 2024 Sep;34(9):6060-6071. Epub 2024 Feb 7 doi: 10.1007/s00330-024-10587-w. PMID: 38326448Free PMC Article
Temporal Bone Histopathology in Cockayne Syndrome.
Handzel O, Nadol JB Jr
Otol Neurotol 2018 Jun;39(5):e387-e391. doi: 10.1097/MAO.0000000000001801. PMID: 29649050Free PMC Article
Acoustically evoked short latency negative responses in hearing loss patients with enlarged vestibular aqueduct.
Liu L, Yang B
Acta Neurol Belg 2013 Jun;113(2):157-60. Epub 2012 Oct 2 doi: 10.1007/s13760-012-0138-6. PMID: 23055113
Vestibulo-ocular physiology underlying vestibular hypofunction.
Schubert MC, Minor LB
Phys Ther 2004 Apr;84(4):373-85. PMID: 15049730
Torsional vestibulo-ocular reflex measurements for identifying otolith asymmetries possibly related to space motion sickness susceptibility.
Peterka RJ
Acta Astronaut 1994 Jul;33:1-8. doi: 10.1016/0094-5765(94)90101-5. PMID: 11539508

Clinical prediction guides

The vestibular calyceal junction is dismantled following subchronic streptomycin in rats and sensory epithelium stress in humans.
Maroto AF, Borrajo M, Prades S, Callejo À, Amilibia E, Pérez-Grau M, Roca-Ribas F, Castellanos E, Barrallo-Gimeno A, Llorens J
Arch Toxicol 2023 Jul;97(7):1943-1961. Epub 2023 May 17 doi: 10.1007/s00204-023-03518-z. PMID: 37195449Free PMC Article
Retro-labyrinthine Lesion Site Detected by Galvanic Vestibular Stimulation Elicited Vestibular-evoked Myogenic Potentials in Patients with Auditory Neuropathy.
Chen ZC, Zhang YZ, Zhao HD, Wei X, Murofushi T, Hu J, Cheng Y, Chen FY, Xu XD, Xu M, Zhang Q
Curr Med Sci 2021 Aug;41(4):695-704. Epub 2021 Aug 17 doi: 10.1007/s11596-021-2411-5. PMID: 34403094
Temporal Bone Histopathology in Cockayne Syndrome.
Handzel O, Nadol JB Jr
Otol Neurotol 2018 Jun;39(5):e387-e391. doi: 10.1097/MAO.0000000000001801. PMID: 29649050Free PMC Article
Behavioural changes in hamsters with otoconial malformations.
Sondag HN, de Jong HA, van Marle J, Oosterveld WJ
Acta Otolaryngol 1998 Jan;118(1):86-9. doi: 10.1080/00016489850155189. PMID: 9504169
Torsional vestibulo-ocular reflex measurements for identifying otolith asymmetries possibly related to space motion sickness susceptibility.
Peterka RJ
Acta Astronaut 1994 Jul;33:1-8. doi: 10.1016/0094-5765(94)90101-5. PMID: 11539508

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