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Benign neoplasm of placenta

MedGen UID:: 146350
•Concept ID:: C0686274
•: Neoplastic Process

Synonyms:	Benign Neoplasm of Placenta; benign neoplasm of placenta; Benign Neoplasm of the Placenta; benign neoplasm of the placenta; Benign Placenta Neoplasm; benign placenta neoplasm; Benign Placenta Tumor; benign placenta tumor; benign placenta tumour; Benign Placental Neoplasm; benign placental neoplasm; Benign Placental Tumor; benign placental tumor; benign placental tumour; Benign Tumor of Placenta; benign tumor of placenta; Benign Tumor of the Placenta; benign tumor of the placenta; benign tumour of placenta; benign tumour of the placenta; placenta benign neoplasm; Placental Neoplasms, Benign; placental neoplasms, benign
SNOMED CT:	Benign neoplasm of placenta (92297008)

Monarch Initiative:	MONDO:0021498

Definition

A neoplasm that arises from the placenta and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign neoplasm of placenta

Neoplasm
- Neoplasm by Special Category
  - Benign neoplasm
    - Benign Genitourinary System Neoplasm
      - Benign reproductive system neoplasm
        Benign female reproductive system neoplasm
        Benign neoplasm of placenta
        Chorangioma
        Placental polyp

Professional guidelines

PubMed

Advances in diagnostics and management of gestational trophoblastic disease.

Lukinovic N, Malovrh EP, Takac I, Sobocan M, Knez J
Radiol Oncol 2022 Dec 1;56(4):430-439. Epub 2022 Oct 27 doi: 10.2478/raon-2022-0038. PMID: 36286620 Free PMC Article

Evaluation and management of abnormal uterine bleeding.

Achanna KS, Nanda J
Med J Malaysia 2022 May;77(3):374-383. PMID: 35638495

Diagnosis and management of gestational trophoblastic disease: 2021 update.

Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197 Free PMC Article

See all (135)

Recent clinical studies

Etiology

Hydatidiform mole.

Daumová M, Hadravská Š, Putzová M
Cesk Patol 2023 Summer;59(2):50-54. PMID: 37468322

Advances in diagnostics and management of gestational trophoblastic disease.

Lukinovic N, Malovrh EP, Takac I, Sobocan M, Knez J
Radiol Oncol 2022 Dec 1;56(4):430-439. Epub 2022 Oct 27 doi: 10.2478/raon-2022-0038. PMID: 36286620 Free PMC Article

Uterine Fibroids and Pregnancy: How Do They Affect Each Other?

Coutinho LM, Assis WA, Spagnuolo-Souza A, Reis FM
Reprod Sci 2022 Aug;29(8):2145-2151. Epub 2021 Jun 17 doi: 10.1007/s43032-021-00656-6. PMID: 34142343

Pathology of gestational trophoblastic disease (GTD).

Kaur B
Best Pract Res Clin Obstet Gynaecol 2021 Jul;74:3-28. Epub 2021 Mar 31 doi: 10.1016/j.bpobgyn.2021.02.005. PMID: 34219021

Autophagy in the physiological endometrium and cancer.

Devis-Jauregui L, Eritja N, Davis ML, Matias-Guiu X, Llobet-Navàs D
Autophagy 2021 May;17(5):1077-1095. Epub 2020 May 13 doi: 10.1080/15548627.2020.1752548. PMID: 32401642 Free PMC Article

See all (1137)

Diagnosis

Advances in diagnostics and management of gestational trophoblastic disease.

Lukinovic N, Malovrh EP, Takac I, Sobocan M, Knez J
Radiol Oncol 2022 Dec 1;56(4):430-439. Epub 2022 Oct 27 doi: 10.2478/raon-2022-0038. PMID: 36286620 Free PMC Article

Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics.

Kanai Y
Pharmacol Ther 2022 Feb;230:107964. Epub 2021 Aug 12 doi: 10.1016/j.pharmthera.2021.107964. PMID: 34390745

Uterine Fibroids and Pregnancy: How Do They Affect Each Other?

Coutinho LM, Assis WA, Spagnuolo-Souza A, Reis FM
Reprod Sci 2022 Aug;29(8):2145-2151. Epub 2021 Jun 17 doi: 10.1007/s43032-021-00656-6. PMID: 34142343

Pathology of gestational trophoblastic disease (GTD).

Kaur B
Best Pract Res Clin Obstet Gynaecol 2021 Jul;74:3-28. Epub 2021 Mar 31 doi: 10.1016/j.bpobgyn.2021.02.005. PMID: 34219021

Placental mesenchymal dysplasia.

Pawoo N, Heller DS
Arch Pathol Lab Med 2014 Sep;138(9):1247-9. doi: 10.5858/arpa.2013-0399-RS. PMID: 25171710

See all (1789)

Therapy

Biology and therapeutic targeting of vascular endothelial growth factor A.

Pérez-Gutiérrez L, Ferrara N
Nat Rev Mol Cell Biol 2023 Nov;24(11):816-834. Epub 2023 Jul 25 doi: 10.1038/s41580-023-00631-w. PMID: 37491579

First-in-Human, Phase I Dose-Escalation and Dose-Expansion Study of Trophoblast Cell-Surface Antigen 2-Directed Antibody-Drug Conjugate Datopotamab Deruxtecan in Non-Small-Cell Lung Cancer: TROPION-PanTumor01.

Shimizu T, Sands J, Yoh K, Spira A, Garon EB, Kitazono S, Johnson ML, Meric-Bernstam F, Tolcher AW, Yamamoto N, Greenberg J, Kawasaki Y, Zebger-Gong H, Kobayashi F, Phillips P, Lisberg AE, Heist RS
J Clin Oncol 2023 Oct 10;41(29):4678-4687. Epub 2023 Jun 16 doi: 10.1200/JCO.23.00059. PMID: 37327461 Free PMC Article

Uterine Fibroids and Pregnancy: How Do They Affect Each Other?

Coutinho LM, Assis WA, Spagnuolo-Souza A, Reis FM
Reprod Sci 2022 Aug;29(8):2145-2151. Epub 2021 Jun 17 doi: 10.1007/s43032-021-00656-6. PMID: 34142343

Diagnosis and management of gestational trophoblastic disease: 2021 update.

Difficult caesarean section: A literature review.

Visconti F, Quaresima P, Rania E, Palumbo AR, Micieli M, Zullo F, Venturella R, Di Carlo C
Eur J Obstet Gynecol Reprod Biol 2020 Mar;246:72-78. Epub 2020 Jan 7 doi: 10.1016/j.ejogrb.2019.12.026. PMID: 31962259

See all (651)

Prognosis

Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics.

Kanai Y
Pharmacol Ther 2022 Feb;230:107964. Epub 2021 Aug 12 doi: 10.1016/j.pharmthera.2021.107964. PMID: 34390745

Pathology of gestational trophoblastic disease (GTD).

Kaur B
Best Pract Res Clin Obstet Gynaecol 2021 Jul;74:3-28. Epub 2021 Mar 31 doi: 10.1016/j.bpobgyn.2021.02.005. PMID: 34219021

Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint.

Wischhusen J, Melero I, Fridman WH
Front Immunol 2020;11:951. Epub 2020 May 19 doi: 10.3389/fimmu.2020.00951. PMID: 32508832 Free PMC Article

Placental chorioangioma: literature review.

Fan M, Skupski DW
J Perinat Med 2014 May;42(3):273-9. doi: 10.1515/jpm-2013-0170. PMID: 24334427

Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers.

Rousseaux S, Debernardi A, Jacquiau B, Vitte AL, Vesin A, Nagy-Mignotte H, Moro-Sibilot D, Brichon PY, Lantuejoul S, Hainaut P, Laffaire J, de Reyniès A, Beer DG, Timsit JF, Brambilla C, Brambilla E, Khochbin S
Sci Transl Med 2013 May 22;5(186):186ra66. doi: 10.1126/scitranslmed.3005723. PMID: 23698379 Free PMC Article

See all (915)

Clinical prediction guides

Hydatidiform mole.

Daumová M, Hadravská Š, Putzová M
Cesk Patol 2023 Summer;59(2):50-54. PMID: 37468322

Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint.

Wischhusen J, Melero I, Fridman WH
Front Immunol 2020;11:951. Epub 2020 May 19 doi: 10.3389/fimmu.2020.00951. PMID: 32508832 Free PMC Article

Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments.

Sun K, Jiang P, Chan KC, Wong J, Cheng YK, Liang RH, Chan WK, Ma ES, Chan SL, Cheng SH, Chan RW, Tong YK, Ng SS, Wong RS, Hui DS, Leung TN, Leung TY, Lai PB, Chiu RW, Lo YM
Proc Natl Acad Sci U S A 2015 Oct 6;112(40):E5503-12. Epub 2015 Sep 21 doi: 10.1073/pnas.1508736112. PMID: 26392541 Free PMC Article

Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers.

Hyperglycosylated hCG.

Cole LA
Placenta 2007 Oct;28(10):977-86. Epub 2007 Mar 7 doi: 10.1016/j.placenta.2007.01.011. PMID: 17346790

See all (1269)

Recent systematic reviews

Maternal and fetal outcomes of intraplacental choriocarcinoma complicated by fetomaternal hemorrhage: a systematic review.

Stabile G, Gentile RM, Carlucci S, Stampalija T, Biffi S, Oletto G, Guido M, Bruno M
J Matern Fetal Neonatal Med 2023 Dec;36(2):2285238. Epub 2023 Nov 27 doi: 10.1080/14767058.2023.2285238. PMID: 38010764

Reproductive and Obstetric Outcomes after UAE, HIFU, and TFA of Uterine Fibroids: Systematic Review and Meta-Analysis.

Akhatova A, Aimagambetova G, Bapayeva G, Laganà AS, Chiantera V, Oppelt P, Sarria-Santamera A, Terzic M
Int J Environ Res Public Health 2023 Mar 2;20(5) doi: 10.3390/ijerph20054480. PMID: 36901489 Free PMC Article

Systematic review of fetal and placental metastases among pregnant patients with cancer.

Khazzaka A, Rassy E, Sleiman Z, Boussios S, Pavlidis N
Cancer Treat Rev 2022 Mar;104:102356. Epub 2022 Feb 11 doi: 10.1016/j.ctrv.2022.102356. PMID: 35182890

Radiofrequency Ablation of Uterine Myomas and Pregnancy Outcomes: An Updated Review of the Literature.

Polin M, Hur HC
J Minim Invasive Gynecol 2022 Jun;29(6):709-715. Epub 2022 Feb 2 doi: 10.1016/j.jmig.2022.01.015. PMID: 35123041

Systematic review of reproductive outcomes after High Intensity Focused Ultrasound treatment of uterine fibroids.

Anneveldt KJ, van 't Oever HJ, Nijholt IM, Dijkstra JR, Hehenkamp WJ, Veersema S, Huirne JAF, Schutte JM, Boomsma MF
Eur J Radiol 2021 Aug;141:109801. Epub 2021 May 27 doi: 10.1016/j.ejrad.2021.109801. PMID: 34116454

See all (30)

MedGen

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Benign neoplasm of placenta

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

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