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Benign female reproductive system neoplasm

MedGen UID:: 152872
•Concept ID:: C0744514
•: Neoplastic Process

Synonyms:	Benign Female Reproductive System Neoplasm; benign female reproductive system neoplasm; Benign Female Reproductive System Tumor; benign female reproductive system tumor; benign female reproductive system tumour; Benign Gynecologic Neoplasm; benign gynecologic neoplasm; Benign Gynecologic Tumor; benign gynecologic tumor; benign gynecologic tumour; female reproductive organ benign neoplasm

Monarch Initiative:	MONDO:0000624

Definition

A neoplasm that arises from the female reproductive system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign female reproductive system neoplasm

Disease
- Neoplasm
  - Neoplasm by Special Category
    - Benign neoplasm
      - Benign Genitourinary System Neoplasm
        Benign reproductive system neoplasm
        Benign female reproductive system neoplasm
        Adenomyoma
        Adenomyoma of uterine corpus
        Uterine corpus atypical polypoid adenomyoma
        Atypical polypoid adenomyoma
        Cervical atypical polypoid adenomyoma
        Cervical adenomyoma
        Cervical Adenomyoma, Mesonephric-Type
        Endocervical type cervical adenomyoma
        Uterine Ligament Adenomyoma
        Benign neoplasm of placenta
        Chorangioma
        Placental polyp
        Benign uterine ligament neoplasm
        Benign Broad Ligament Neoplasm
        Broad Ligament Leiomyoma
        Broad Ligament Papillary Cystadenoma
        Broad Ligament Serous Cystadenoma
        Uterine Ligament Leiomyoma
        Uterine Ligament Papillary Cystadenoma
        Uterine ligament papillary cystadenoma associated with von Hippel-Lindau disease
        Benign vaginal neoplasm
        Benign Vaginal Melanocytic Nevus
        Vaginal Blue Nevus
        Benign vaginal mixed epithelial and mesenchymal neoplasm
        Benign vaginal mixed tumor
        Vaginal Angiomyofibroblastoma
        Vaginal Deep (Aggressive) Angiomyxoma
        Vaginal Dermoid Cyst
        Vaginal leiomyoma
        Vaginal mullerian papilloma
        Vaginal Rhabdomyoma
        Vaginal squamous papilloma
        Vaginal Superficial Myofibroblastoma
        Fallopian tube benign neoplasm
        Fallopian tube adenomatoid tumor
        Fallopian tube leiomyoma
        Fallopian Tube Metaplastic Papillary Tumor
        Fallopian tube papilloma
        Fallopian tube serous adenofibroma
        Fallopian tube cystadenofibroma
        Genital Rhabdomyoma
        Cervical Rhabdomyoma
        Vulvar Rhabdomyoma
        Mucinous cystadenofibroma
        Ovarian mucinous cystadenofibroma
        Ovarian benign neoplasm
        Benign Ovarian Epithelial Tumor
        Benign Ovarian Brenner Tumor
        Benign Ovarian Clear Cell Tumor
        Benign Ovarian Endometrioid Tumor
        Benign ovarian mucinous tumor
        Benign Ovarian Seromucinous Tumor
        Benign Ovarian Serous Tumor
        Ovarian cystadenoma
        Benign Ovarian Germ Cell Tumor
        Mature ovarian teratoma
        Benign ovarian sex cord-stromal tumor
        Benign Ovarian Thecoma
        Fibroma of ovary
        Ovarian microcystic stromal tumor
        Ovarian Sclerosing Stromal Tumor
        Ovarian Stromal-Leydig Cell Tumor
        Ovarian Adenomatoid Tumor
        Ovarian Leiomyoma
        Ovarian Myxoma
        Rete ovarii adenoma
        Uterine benign neoplasm
        Benign neoplasm of corpus uteri
        Benign neoplasm of endometrium
        Benign Uterine Corpus Mixed Epithelial and Mesenchymal Neoplasm
        Benign Uterine Corpus PEComa
        Endometrial polyp
        Endometrial stromal nodule
        Uterine corpus adenomatoid tumor
        Uterine leiomyoma
        Cervical benign neoplasm
        Benign Cervical Mixed Epithelial and Mesenchymal Neoplasm
        Benign Cervical Soft Tissue Neoplasm
        Cervical Blue Nevus
        Cervical mullerian papilloma
        Cervix squamous papilloma
        Endocervical Polyp
        Vulvar benign neoplasm
        Bartholin gland benign neoplasm
        Bartholin gland adenoma
        Bartholin gland adenomyoma
        Benign mixed tumor of the vulva
        Benign Vulvar Phyllodes Tumor
        Minor vestibular glands adenoma
        Vestibular papilloma
        Vestibular micropapillomatosis
        Vulvar Acquired Melanocytic Nevus
        Vulvar Angiomyofibroblastoma
        Vulvar Angiomyxoma
        Vulvar Deep (Aggressive) Angiomyxoma
        Vulvar Superficial Angiomyxoma
        Vulvar Blue Nevus
        Vulvar Cellular Angiofibroma
        Vulvar Composite Hidradenoma Papilliferum and Fibroadenoma
        Vulvar Congenital Melanocytic Nevus
        Vulvar Fibroadenoma
        Vulvar Hidradenoma Papilliferum
        Vulvar leiomyoma
        Vulvar Lipoblastoma-Like Tumor
        Vulvar Lipoma
        Vulvar Fibrolipoma
        Vulvar nodular hidradenoma
        Vulvar Prepubertal Fibroma
        Vulvar seborrheic keratosis
        Vulvar inverted follicular keratosis
        Vulvar Superficial Myofibroblastoma
        Vulvar syringoma
        Vulvar trichoepithelioma

Professional guidelines

PubMed

Diagnosis and management of uterine fibroids: current trends and future strategies.

Ahmad A, Kumar M, Bhoi NR, Badruddeen, Akhtar J, Khan MI, Ajmal M, Ahmad M
J Basic Clin Physiol Pharmacol 2023 May 1;34(3):291-310. Epub 2023 Mar 30 doi: 10.1515/jbcpp-2022-0219. PMID: 36989026

Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment.

Yang Q, Ciebiera M, Bariani MV, Ali M, Elkafas H, Boyer TG, Al-Hendy A
Endocr Rev 2022 Jul 13;43(4):678-719. doi: 10.1210/endrev/bnab039. PMID: 34741454 Free PMC Article

Uterine Fibroids: Diagnosis and Treatment.

De La Cruz MS, Buchanan EM
Am Fam Physician 2017 Jan 15;95(2):100-107. PMID: 28084714

See all (537)

Recent clinical studies

Etiology

Low-grade Serous Neoplasia of the Female Genital Tract.

Folkins AK, Longacre TA
Surg Pathol Clin 2019 Jun;12(2):481-513. doi: 10.1016/j.path.2019.02.006. PMID: 31097112

Microbiological diagnosis of human papilloma virus infection.

Mateos-Lindemann ML, Pérez-Castro S, Rodríguez-Iglesias M, Pérez-Gracia MT
Enferm Infecc Microbiol Clin 2017 Nov;35(9):593-602. Epub 2016 Jun 25 doi: 10.1016/j.eimc.2016.05.008. PMID: 27353835

Uterine Adenosarcoma: a Review.

Nathenson MJ, Ravi V, Fleming N, Wang WL, Conley A
Curr Oncol Rep 2016 Nov;18(11):68. doi: 10.1007/s11912-016-0552-7. PMID: 27718181

Human papillomavirus-associated diseases.

Grce M, Mravak-Stipetić M
Clin Dermatol 2014 Mar-Apr;32(2):253-8. Epub 2013 Oct 30 doi: 10.1016/j.clindermatol.2013.10.006. PMID: 24559561

Reassessing hysterectomy.

Stewart EA, Shuster LT, Rocca WA
Minn Med 2012 Mar;95(3):36-9. PMID: 22611818 Free PMC Article

See all (5242)

Diagnosis

Gynecologic cancer in pregnancy.

Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951 Free PMC Article

Uterine Adenosarcoma: a Review.

Nathenson MJ, Ravi V, Fleming N, Wang WL, Conley A
Curr Oncol Rep 2016 Nov;18(11):68. doi: 10.1007/s11912-016-0552-7. PMID: 27718181

Benign gynecologic conditions.

Boyle KJ, Torrealday S
Surg Clin North Am 2008 Apr;88(2):245-64, v. doi: 10.1016/j.suc.2007.12.001. PMID: 18381112

Female pelvis.

Brown MA, Sirlin CB
Magn Reson Imaging Clin N Am 2005 May;13(2):381-95. doi: 10.1016/j.mric.2005.03.001. PMID: 15935318

Pelvic Doppler.

Levine D
Semin Ultrasound CT MR 1999 Aug;20(4):239-49. doi: 10.1016/s0887-2171(99)90069-0. PMID: 10457564

See all (7237)

Therapy

The Role of Nutrition in Pathogenesis of Uterine Fibroids.

Krzyżanowski J, Paszkowski T, Woźniak S
Nutrients 2023 Dec 1;15(23) doi: 10.3390/nu15234984. PMID: 38068842 Free PMC Article

Endometrial hyperplasia as a risk factor of endometrial cancer.

Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185 Free PMC Article

Uterine Fibroids and Diet.

Tinelli A, Vinciguerra M, Malvasi A, Andjić M, Babović I, Sparić R
Int J Environ Res Public Health 2021 Jan 25;18(3) doi: 10.3390/ijerph18031066. PMID: 33504114 Free PMC Article

High-intensity focused ultrasound therapy.

Cheung VYT
Best Pract Res Clin Obstet Gynaecol 2018 Jan;46:74-83. Epub 2017 Oct 3 doi: 10.1016/j.bpobgyn.2017.09.002. PMID: 29074037

Uterine fibroid management: from the present to the future.

Donnez J, Dolmans MM
Hum Reprod Update 2016 Nov;22(6):665-686. Epub 2016 Jul 27 doi: 10.1093/humupd/dmw023. PMID: 27466209 Free PMC Article

See all (1497)

Prognosis

Gynecologic cancer in pregnancy.

Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951 Free PMC Article

Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria.

Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670 Free PMC Article

Uterine Adenosarcoma: a Review.

Nathenson MJ, Ravi V, Fleming N, Wang WL, Conley A
Curr Oncol Rep 2016 Nov;18(11):68. doi: 10.1007/s11912-016-0552-7. PMID: 27718181

Risk of Occult Uterine Sarcoma in Presumed Uterine Fibroids.

Cui RR, Wright JD
Clin Obstet Gynecol 2016 Mar;59(1):103-18. doi: 10.1097/GRF.0000000000000163. PMID: 26645385

Global burden of human papillomavirus and related diseases.

Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, Vignat J, Ferlay J, Bray F, Plummer M, Franceschi S
Vaccine 2012 Nov 20;30 Suppl 5:F12-23. doi: 10.1016/j.vaccine.2012.07.055. PMID: 23199955

See all (3737)

Clinical prediction guides

Reducing Unnecessary Oophorectomies for Benign Ovarian Neoplasms in Pediatric Patients.

Minneci PC, Bergus KC, Lutz C, Aldrink J, Bence C, Breech L, Dillon PA, Downard C, Ehrlich PF, Fallat M, Fraser JD, Grabowski J, Helmrath M, Hertweck P, Hewitt G, Hirschl RB, Kabre R, Lal DR, Landman M, Leys C, Mak G, Markel T, Pressey J, Raiji M, Rymeski B, Saito J, Sato TT, St Peter SD, Cooper J, Deans K; Midwest Pediatric Surgery Consortium
JAMA 2023 Oct 3;330(13):1247-1254. doi: 10.1001/jama.2023.17183. PMID: 37787794 Free PMC Article

Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria.

Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670 Free PMC Article

Imaging of Adnexal Masses.

Thakur M, Timmerman D
Clin Obstet Gynecol 2017 Mar;60(1):38-45. doi: 10.1097/GRF.0000000000000261. PMID: 28005597

Evaluating the risk of ovarian cancer before surgery using the ADNEX model to differentiate between benign, borderline, early and advanced stage invasive, and secondary metastatic tumours: prospective multicentre diagnostic study.

Van Calster B, Van Hoorde K, Valentin L, Testa AC, Fischerova D, Van Holsbeke C, Savelli L, Franchi D, Epstein E, Kaijser J, Van Belle V, Czekierdowski A, Guerriero S, Fruscio R, Lanzani C, Scala F, Bourne T, Timmerman D; International Ovarian Tumour Analysis Group
BMJ 2014 Oct 15;349:g5920. doi: 10.1136/bmj.g5920. PMID: 25320247 Free PMC Article

Simple ultrasound-based rules for the diagnosis of ovarian cancer.

Timmerman D, Testa AC, Bourne T, Ameye L, Jurkovic D, Van Holsbeke C, Paladini D, Van Calster B, Vergote I, Van Huffel S, Valentin L
Ultrasound Obstet Gynecol 2008 Jun;31(6):681-90. doi: 10.1002/uog.5365. PMID: 18504770

See all (3625)

Recent systematic reviews

Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review.

Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127 Free PMC Article

Endometrial hyperplasia as a risk factor of endometrial cancer.

Surgical treatment of fibroids for subfertility.

Metwally M, Raybould G, Cheong YC, Horne AW
Cochrane Database Syst Rev 2020 Jan 29;1(1):CD003857. doi: 10.1002/14651858.CD003857.pub4. PMID: 31995657 Free PMC Article

Laparoscopic management of uncommon benign uterine tumors: a systematic review.

Sleiman Z, Hussein S, Mohsen A, Khazzaka A, Tropea A, Biondi A
Updates Surg 2019 Dec;71(4):637-643. Epub 2019 Apr 2 doi: 10.1007/s13304-019-00651-2. PMID: 30941703

Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women: A Systematic Review and Meta-analysis.

Clarke MA, Long BJ, Del Mar Morillo A, Arbyn M, Bakkum-Gamez JN, Wentzensen N
JAMA Intern Med 2018 Sep 1;178(9):1210-1222. doi: 10.1001/jamainternmed.2018.2820. PMID: 30083701 Free PMC Article

See all (149)

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Benign female reproductive system neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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