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Tongue carcinoma

MedGen UID:
154320
•Concept ID:
C0558353
•
Neoplastic Process
Synonyms: Cancer of the Tongue; Cancer of Tongue; Carcinoma of the Tongue; Carcinoma of Tongue; Tongue Cancer; Tongue Carcinoma; tongue carcinoma
SNOMED CT: Tongue carcinoma (269516007)
 
Monarch Initiative: MONDO:0850154

Definition

A malignant tumor arising from the epithelium that covers the tongue. The vast majority of tongue carcinomas are moderately or poorly differentiated squamous cell carcinomas. [from NCI]

Professional guidelines

PubMed

Prognostic outcomes of treatment naïve oral tongue squamous cell carcinoma (OTSCC): a comprehensive analysis of 14 years.
Faisal M, Dhanani R, Ullah S, Bakar MA, Irfan N, Malik KI, Loya A, Boban EM, Hussain R, Jamshed A
Eur Arch Otorhinolaryngol 2021 Aug;278(8):3045-3053. Epub 2020 Nov 25 doi: 10.1007/s00405-020-06482-x. PMID: 33236214
Management of advanced carcinoma of the base of tongue.
Karatzanis AD, Psychogios G, Mantsopoulos K, Zenk J, Velegrakis GA, Waldfahrer F, Iro H
J Surg Oncol 2012 Nov;106(6):713-8. Epub 2012 Apr 24 doi: 10.1002/jso.23135. PMID: 22532105
Treatment of carcinoma of base of tongue with radiation therapy and 5-fluorouracil. Potential for optimization with 18F-FU.
Wiley AL Jr, Ramirez G, Johnson RO, Brandenburg JH, Lieberman LM, Lo TC, Vermund H
Acta Radiol Oncol Radiat Phys Biol 1979;18(3):235-43. doi: 10.3109/02841867909128211. PMID: 118641

Recent clinical studies

Etiology

Squamous cell carcinoma of the tongue: subtypes and morphological features affecting prognosis.
Matsuo K, Akiba J, Kusukawa J, Yano H
Am J Physiol Cell Physiol 2022 Dec 1;323(6):C1611-C1623. Epub 2022 Oct 17 doi: 10.1152/ajpcell.00098.2022. PMID: 36252129
Carcinoma Tongue--Clinicopathological Presentation.
Majumder KR, Karmakar R, Alam MM, Rahman T
Mymensingh Med J 2015 Oct;24(4):787-93. PMID: 26620021
Ultrasonic partial glossectomy.
Pons Y, Gauthier J, Clément P, Conessa C
Head Neck Oncol 2009 Jun 24;1:21. doi: 10.1186/1758-3284-1-21. PMID: 19552821Free PMC Article
Video-assisted lobectomy in the elderly.
Asamura H, Nakayama H, Kondo H, Tsuchiya R, Naruke T
Chest 1997 Apr;111(4):1101-5. doi: 10.1378/chest.111.4.1101. PMID: 9106593
Total glossectomy.
Razack MS, Sako K, Bakamjian VY, Shedd DP
Am J Surg 1983 Oct;146(4):509-11. doi: 10.1016/0002-9610(83)90242-8. PMID: 6625097

Diagnosis

Preoperative MRI for oral tongue squamous cell carcinoma: timing and correlation to histopathology.
Rozendorn N, Greenberg G, Madgar O, Gluck I, Vered M, Alon E, Dobriyan A
Int J Oral Maxillofac Surg 2023 Mar;52(3):291-295. Epub 2022 Aug 8 doi: 10.1016/j.ijom.2022.07.003. PMID: 35953345
Squamous cell carcinoma of the tongue: subtypes and morphological features affecting prognosis.
Matsuo K, Akiba J, Kusukawa J, Yano H
Am J Physiol Cell Physiol 2022 Dec 1;323(6):C1611-C1623. Epub 2022 Oct 17 doi: 10.1152/ajpcell.00098.2022. PMID: 36252129
Tongue carcinoma as a secondary malignancy in a 17-year-old leukemia survivor: A case report.
de Mendonça RMH, Cappellaro KMC, Gueiros LA, Cardinalli IA, Arboleda LPA, Santos-Silva AR
Spec Care Dentist 2021 Jul;41(4):532-538. Epub 2021 Mar 23 doi: 10.1111/scd.12590. PMID: 33757161
Incidentally detected arterial thrombosis in (99m)Tc-methylene diphosphonate skeletal scintigraphy: an atypical observation.
Pruthi A, Chauhan VV, Rao SA, Choudhury PS
Clin Nucl Med 2014 Feb;39(2):190-2. doi: 10.1097/RLU.0b013e318292eef9. PMID: 23676657
Video-assisted lobectomy in the elderly.
Asamura H, Nakayama H, Kondo H, Tsuchiya R, Naruke T
Chest 1997 Apr;111(4):1101-5. doi: 10.1378/chest.111.4.1101. PMID: 9106593

Therapy

Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer.
Gupta P, Singh M, Kumar R, Belz J, Shanker R, Dwivedi PD, Sridhar S, Singh SP
Int J Nanomedicine 2018;13(T-NANO 2014 Abstracts):67-69. Epub 2018 Mar 15 doi: 10.2147/IJN.S124995. PMID: 29593398Free PMC Article
Carcinoma Tongue--Clinicopathological Presentation.
Majumder KR, Karmakar R, Alam MM, Rahman T
Mymensingh Med J 2015 Oct;24(4):787-93. PMID: 26620021
Sporamin induce apoptosis in human tongue carcinoma cells by down-regulating Akt/GSK-3 signaling.
Yao J, Qian C
Fundam Clin Pharmacol 2011 Apr;25(2):229-36. doi: 10.1111/j.1472-8206.2010.00830.x. PMID: 20408878
Ultrasonic partial glossectomy.
Pons Y, Gauthier J, Clément P, Conessa C
Head Neck Oncol 2009 Jun 24;1:21. doi: 10.1186/1758-3284-1-21. PMID: 19552821Free PMC Article
Pulmonary toxicity by a cytotoxic agent, S-1.
Tada Y, Takiguchi Y, Fujikawa A, Kitamura A, Kurosu K, Hiroshima K, Sakao S, Kasahara Y, Tanabe N, Tatsumi K, Kuriyama T
Intern Med 2007;46(15):1243-6. Epub 2007 Aug 2 doi: 10.2169/internalmedicine.46.0146. PMID: 17675777

Prognosis

Tongue Carcinoma - 20-Year Comparative Survival and Mortality Analysis by Age, Sex, Race, Stage, Grade, Cohort Entry Time-Period and Disease Duration.
Milano AF
J Insur Med 2023 Jul 1;50(2):123-138. doi: 10.17849/insm-50-2-123-138.1. PMID: 38358928
Squamous cell carcinoma of the tongue: subtypes and morphological features affecting prognosis.
Matsuo K, Akiba J, Kusukawa J, Yano H
Am J Physiol Cell Physiol 2022 Dec 1;323(6):C1611-C1623. Epub 2022 Oct 17 doi: 10.1152/ajpcell.00098.2022. PMID: 36252129
Tongue carcinoma in young adults: a review of the literature.
Paderno A, Morello R, Piazza C
Acta Otorhinolaryngol Ital 2018 Jun;38(3):175-180. doi: 10.14639/0392-100X-1932. PMID: 29984792Free PMC Article
Tongue carcinoma in a young patient with dermatomyositis: a case report and review of the literature.
Sugiyama T, Nakagawa T, Inui M, Tagawa T
J Oral Maxillofac Surg 2001 Aug;59(8):925-8. doi: 10.1053/joms.2001.25033. PMID: 11474455
Total glossectomy.
Razack MS, Sako K, Bakamjian VY, Shedd DP
Am J Surg 1983 Oct;146(4):509-11. doi: 10.1016/0002-9610(83)90242-8. PMID: 6625097

Clinical prediction guides

Squamous cell carcinoma of the tongue: subtypes and morphological features affecting prognosis.
Matsuo K, Akiba J, Kusukawa J, Yano H
Am J Physiol Cell Physiol 2022 Dec 1;323(6):C1611-C1623. Epub 2022 Oct 17 doi: 10.1152/ajpcell.00098.2022. PMID: 36252129
Tongue carcinoma in young adults: a review of the literature.
Paderno A, Morello R, Piazza C
Acta Otorhinolaryngol Ital 2018 Jun;38(3):175-180. doi: 10.14639/0392-100X-1932. PMID: 29984792Free PMC Article
Carcinoma Tongue--Clinicopathological Presentation.
Majumder KR, Karmakar R, Alam MM, Rahman T
Mymensingh Med J 2015 Oct;24(4):787-93. PMID: 26620021
Incidentally detected arterial thrombosis in (99m)Tc-methylene diphosphonate skeletal scintigraphy: an atypical observation.
Pruthi A, Chauhan VV, Rao SA, Choudhury PS
Clin Nucl Med 2014 Feb;39(2):190-2. doi: 10.1097/RLU.0b013e318292eef9. PMID: 23676657
Base of tongue carcinoma: patterns of failure and predictors of recurrence after surgery alone.
Foote RL, Olsen KD, Davis DL, Buskirk SJ, Stanley RJ, Kunselman SJ, Schaid DJ, DeSanto LW
Head Neck 1993 Jul-Aug;15(4):300-7. doi: 10.1002/hed.2880150406. PMID: 8360051

Recent systematic reviews

Elective node dissection versus observation for management of patients with early-stage cT1/T2N0 tongue carcinoma: A systematic review and meta-analysis of prospective studies.
Alsini AY, Alsubaie HM, Marzouki HZ, Abu-Zaid A, Al-Qahtani K
Clin Otolaryngol 2021 Jul;46(4):720-728. Epub 2021 May 6 doi: 10.1111/coa.13781. PMID: 33840160
Level IV neck dissection as an elective treatment for oral tongue carcinoma-a systematic review and meta-analysis.
Weisz Shabtay N, Ronen O
Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Oct;130(4):363-372. Epub 2020 Jun 13 doi: 10.1016/j.oooo.2020.04.810. PMID: 32540318
Utility of intraoral ultrasound in managing oral tongue squamous cell carcinoma: Systematic review.
Tarabichi O, Bulbul MG, Kanumuri VV, Faquin WC, Juliano AF, Cunnane ME, Varvares MA
Laryngoscope 2019 Mar;129(3):662-670. Epub 2018 Aug 27 doi: 10.1002/lary.27403. PMID: 30151976

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