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Breast Pleomorphic Lobular Carcinoma In Situ

MedGen UID:
1614177
•Concept ID:
C4527240
•
Neoplastic Process
Synonyms: Non-Invasive Pleomorphic Lobular Carcinoma of the Breast; Pleomorphic Lobular Breast Carcinoma In Situ; Pleomorphic lobular carcinoma in situ of breast; Pleomorphic Lobular Carcinoma in Situ of the Breast
SNOMED CT: Pleomorphic lobular carcinoma in situ of breast (762260000)

Definition

Breast lobular carcinoma in situ characterized by the presence of neoplastic large cells with marked nuclear pleomorphism. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Pleomorphic Lobular Carcinoma In Situ

Professional guidelines

PubMed

Evidence-Based Pragmatic Approach to the Management of Borderline or High-Risk Breast Lesions.
Lamb LR, Bahl M
AJR Am J Roentgenol 2022 Jan;218(1):186-187. Epub 2021 Jul 21 doi: 10.2214/AJR.21.26340. PMID: 34286593
Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Uncertainties in the management of pleomorphic lobular carcinoma in situ of the breast still remain.
Altundag K
J BUON 2018 Jan-Feb;23(1):273. PMID: 29552796

Recent clinical studies

Etiology

Update on Lobular Neoplasia.
Heller SL, Gao Y
Radiographics 2023 Oct;43(10):e220188. doi: 10.1148/rg.220188. PMID: 37676825
Lobular Neoplasia.
Lunt L, Coogan A, Perez CB
Surg Clin North Am 2022 Dec;102(6):947-963. doi: 10.1016/j.suc.2022.07.001. PMID: 36335930
Adenomyoepithelioma of the breast: a proposal for classification.
Rakha E, Tan PH, Ellis I, Quinn C
Histopathology 2021 Oct;79(4):465-479. Epub 2021 Jun 13 doi: 10.1111/his.14380. PMID: 33829532
Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Lobular Carcinoma In Situ.
Wen HY, Brogi E
Surg Pathol Clin 2018 Mar;11(1):123-145. Epub 2017 Dec 8 doi: 10.1016/j.path.2017.09.009. PMID: 29413653Free PMC Article

Diagnosis

Update on Lobular Neoplasia.
Heller SL, Gao Y
Radiographics 2023 Oct;43(10):e220188. doi: 10.1148/rg.220188. PMID: 37676825
Lobular Neoplasia.
Lunt L, Coogan A, Perez CB
Surg Clin North Am 2022 Dec;102(6):947-963. doi: 10.1016/j.suc.2022.07.001. PMID: 36335930
Apocrine lesions of the breast.
Quinn CM, D'Arcy C, Wells C
Virchows Arch 2022 Jan;480(1):177-189. Epub 2021 Sep 18 doi: 10.1007/s00428-021-03185-4. PMID: 34537861Free PMC Article
Adenomyoepithelioma of the breast: a proposal for classification.
Rakha E, Tan PH, Ellis I, Quinn C
Histopathology 2021 Oct;79(4):465-479. Epub 2021 Jun 13 doi: 10.1111/his.14380. PMID: 33829532
Lobular Carcinoma In Situ.
Wen HY, Brogi E
Surg Pathol Clin 2018 Mar;11(1):123-145. Epub 2017 Dec 8 doi: 10.1016/j.path.2017.09.009. PMID: 29413653Free PMC Article

Therapy

Changes in Invasive Breast Carcinomas after Neoadjuvant Chemotherapy Can Influence Adjuvant Therapeutic Decisions.
Jaime Dos Santos B, Balabram D, Mara Reis Gomes V, Costa Café de Castro C, Henrique Costa Diniz P, Araújo Buzelin M, Buzelin Nunes C
Cancer Res Treat 2024 Jan;56(1):178-190. Epub 2023 Aug 1 doi: 10.4143/crt.2023.386. PMID: 37536712Free PMC Article
Breast-conserving surgery for pure non-classic lobular carcinoma in situ: A single institution's experience.
Hoffman DI, Zhang PJ, Tchou J
Surg Oncol 2019 Mar;28:190-194. Epub 2019 Jan 29 doi: 10.1016/j.suronc.2019.01.009. PMID: 30851899
Treatment Outcomes for Pleomorphic Lobular Carcinoma In Situ of the Breast.
Desai AA, Jimenez RE, Hoskin TL, Day CN, Boughey JC, Hieken TJ
Ann Surg Oncol 2018 Oct;25(10):3064-3068. Epub 2018 Jun 26 doi: 10.1245/s10434-018-6591-6. PMID: 29947004
UK national survey of management of breast lobular carcinoma in situ.
Chester R, Bokinni O, Ahmed I, Kasem A
Ann R Coll Surg Engl 2015 Nov;97(8):574-7. doi: 10.1308/rcsann.2015.0037. PMID: 26492902Free PMC Article
Pleomorphic Lobular Carcinoma In Situ: Radiologic-Pathologic Features and Clinical Management.
Flanagan MR, Rendi MH, Calhoun KE, Anderson BO, Javid SH
Ann Surg Oncol 2015 Dec;22(13):4263-9. Epub 2015 Apr 17 doi: 10.1245/s10434-015-4552-x. PMID: 25893410Free PMC Article

Prognosis

Treatment Outcomes for Pleomorphic Lobular Carcinoma In Situ of the Breast.
Desai AA, Jimenez RE, Hoskin TL, Day CN, Boughey JC, Hieken TJ
Ann Surg Oncol 2018 Oct;25(10):3064-3068. Epub 2018 Jun 26 doi: 10.1245/s10434-018-6591-6. PMID: 29947004
Pleomorphic Lobular Carcinoma In Situ: Imaging Features, Upgrade Rate, and Clinical Outcomes.
Savage JL, Jeffries DO, Noroozian M, Sabel MS, Jorns JM, Helvie MA
AJR Am J Roentgenol 2018 Aug;211(2):462-467. Epub 2018 Jun 12 doi: 10.2214/AJR.17.19088. PMID: 29894223
Pleomorphic lobular carcinoma in situ of the breast: a single institution experience with clinical follow-up and centralized pathology review.
De Brot M, Koslow Mautner S, Muhsen S, Andrade VP, Mamtani A, Murray M, Giri D, Sakr RA, Brogi E, King TA
Breast Cancer Res Treat 2017 Sep;165(2):411-420. Epub 2017 Jun 13 doi: 10.1007/s10549-017-4334-1. PMID: 28612228Free PMC Article
Management of lobular carcinoma in-situ and atypical lobular hyperplasia of the breast--a review.
Hussain M, Cunnick GH
Eur J Surg Oncol 2011 Apr;37(4):279-89. doi: 10.1016/j.ejso.2011.01.009. PMID: 21306860
Pleomorphic lobular carcinoma of the breast: molecular pathology and clinical impact.
Vargas AC, Lakhani SR, Simpson PT
Future Oncol 2009 Mar;5(2):233-43. doi: 10.2217/14796694.5.2.233. PMID: 19284381

Clinical prediction guides

The morphologic spectrum of lobular carcinoma in situ (LCIS) observations on clinical significance, management implications and diagnostic pitfalls of classic, florid and pleomorphic LCIS.
Brogi E
Virchows Arch 2022 Dec;481(6):823-837. Epub 2022 May 14 doi: 10.1007/s00428-022-03299-3. PMID: 35567633
Treatment Outcomes for Pleomorphic Lobular Carcinoma In Situ of the Breast.
Desai AA, Jimenez RE, Hoskin TL, Day CN, Boughey JC, Hieken TJ
Ann Surg Oncol 2018 Oct;25(10):3064-3068. Epub 2018 Jun 26 doi: 10.1245/s10434-018-6591-6. PMID: 29947004
Pleomorphic Lobular Carcinoma In Situ: Imaging Features, Upgrade Rate, and Clinical Outcomes.
Savage JL, Jeffries DO, Noroozian M, Sabel MS, Jorns JM, Helvie MA
AJR Am J Roentgenol 2018 Aug;211(2):462-467. Epub 2018 Jun 12 doi: 10.2214/AJR.17.19088. PMID: 29894223
Imaging for the diagnosis and management of ductal carcinoma in situ.
D'Orsi CJ
J Natl Cancer Inst Monogr 2010;2010(41):214-7. doi: 10.1093/jncimonographs/lgq037. PMID: 20956833Free PMC Article
Pleomorphic lobular carcinoma in situ (PLCIS) on breast core needle biopsies: clinical significance and immunoprofile.
Chivukula M, Haynik DM, Brufsky A, Carter G, Dabbs DJ
Am J Surg Pathol 2008 Nov;32(11):1721-6. doi: 10.1097/PAS.0b013e31817dc3a6. PMID: 18769331

Recent systematic reviews

Breast microcalcifications as type descriptors to stratify risk of malignancy: a systematic review and meta-analysis of 10665 cases with special focus on round/punctate microcalcifications.
Rominger M, Wisgickl C, Timmesfeld N
Rofo 2012 Dec;184(12):1144-52. Epub 2012 Aug 24 doi: 10.1055/s-0032-1313102. PMID: 22923222

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