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Breast lobular carcinoma

MedGen UID:
64634
•Concept ID:
C0206692
•
Neoplastic Process
Synonyms: Breast cancer, lobular; BREAST CANCER, LOBULAR, SOMATIC
SNOMED CT: Lobular carcinoma (89740008); Lobular adenocarcinoma (89740008); Infiltrating lobular carcinoma (89740008); Infiltrating lobular carcinoma of breast (278054005); Lobular carcinoma of breast (278054005)
 
Monarch Initiative: MONDO:0000552

Definition

An adenocarcinoma of the breast arising from the lobules. This is a relatively uncommon carcinoma, represents approximately 10% of the breast adenocarcinomas and is often bilateral or multifocal. [from NCI]

Professional guidelines

PubMed

Integration of Pathological Criteria and Immunohistochemical Evaluation for Invasive Lobular Carcinoma Diagnosis: Recommendations From the European Lobular Breast Cancer Consortium.
De Schepper M, Koorman T, Richard F, Christgen M, Vincent-Salomon A, Schnitt SJ, van Diest PJ, Zels G, Mertens F, Maetens M, Vanden Bempt I, Harbeck N, Nitz U, Gräser M, Kümmel S, Gluz O, Weynand B, Floris G, Derksen PWB, Desmedt C; Pathology Working Group of the European Lobular Breast Cancer Consortium
Mod Pathol 2024 Jul;37(7):100497. Epub 2024 Apr 17 doi: 10.1016/j.modpat.2024.100497. PMID: 38641322
Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review.
Birla R, Dinu D, Iosif C, Constantinoiu S
Chirurgia (Bucur) 2019 Sept-Oct;114(5):571-578. doi: 10.21614/chirurgia.114.5.571. PMID: 31670632
Distant metastases from invasive lobular breast carcinoma classic type - treatment and prognosis.
Skotnicki P, Sas-Korczynska B, Wohadlo L, Jakubowicz J, Blecharz P, Reinfuss M, Walasek T
Eur J Gynaecol Oncol 2016;37(5):666-670. PMID: 29787007

Recent clinical studies

Etiology

Triple-negative breast lobular carcinoma: a luminal androgen receptor carcinoma with specific ESRRA mutations.
Bergeron A, MacGrogan G, Bertaut A, Ladoire S, Arveux P, Desmoulins I, Bonnefoi H, Loustalot C, Auriol S, Beltjens F, Degrolard-Courcet E, Charon-Barra C, Richard C, Boidot R, Arnould L
Mod Pathol 2021 Jul;34(7):1282-1296. Epub 2021 Mar 22 doi: 10.1038/s41379-021-00742-9. PMID: 33753865Free PMC Article
Cervical Squamous Carcinomas With Prominent Acantholysis and Areas Resembling Breast Lobular Carcinoma: An Aggressive Form of Dedifferentation.
Scott K, Bryson G, Jamison J, Coutts M, McCluggage WG
Int J Gynecol Pathol 2018 Jan;37(1):74-81. doi: 10.1097/PGP.0000000000000387. PMID: 28700422
Management of breast lobular carcinoma in situ: radio-pathological correlation, clinical implications, and follow-up.
Capobianco G, Simbula L, Soro D, Meloni F, Cossu-Rocca P, Dessole S, Ambrosini G, Cherchi PL, Meloni GB
Eur J Gynaecol Oncol 2014;35(2):157-62. PMID: 24772919
Cervical adenocarcinoma resembling breast lobular carcinoma: a hitherto Undescribed Variant of Primary Cervical Adenocarcinoma.
Mansor S, McCluggage WG
Int J Gynecol Pathol 2010 Nov;29(6):594-9. doi: 10.1097/PGP.0b013e3181e36337. PMID: 20881849
Identification of an aptamer targeting hnRNP A1 by tissue slide-based SELEX.
Li S, Xu H, Ding H, Huang Y, Cao X, Yang G, Li J, Xie Z, Meng Y, Li X, Zhao Q, Shen B, Shao N
J Pathol 2009 Jul;218(3):327-36. doi: 10.1002/path.2543. PMID: 19291713

Diagnosis

Triple-negative breast lobular carcinoma: a luminal androgen receptor carcinoma with specific ESRRA mutations.
Bergeron A, MacGrogan G, Bertaut A, Ladoire S, Arveux P, Desmoulins I, Bonnefoi H, Loustalot C, Auriol S, Beltjens F, Degrolard-Courcet E, Charon-Barra C, Richard C, Boidot R, Arnould L
Mod Pathol 2021 Jul;34(7):1282-1296. Epub 2021 Mar 22 doi: 10.1038/s41379-021-00742-9. PMID: 33753865Free PMC Article
UK national survey of management of breast lobular carcinoma in situ.
Chester R, Bokinni O, Ahmed I, Kasem A
Ann R Coll Surg Engl 2015 Nov;97(8):574-7. doi: 10.1308/rcsann.2015.0037. PMID: 26492902Free PMC Article
Management of breast lobular carcinoma in situ: radio-pathological correlation, clinical implications, and follow-up.
Capobianco G, Simbula L, Soro D, Meloni F, Cossu-Rocca P, Dessole S, Ambrosini G, Cherchi PL, Meloni GB
Eur J Gynaecol Oncol 2014;35(2):157-62. PMID: 24772919
Survivin expression in breast lobular carcinoma: correlations with normal breast tissue and clinicomorphological parameters.
Adamkov M, Výbohová D, Horáček J, Kovalská M, Furjelová M
Acta Histochem 2013 Jun;115(5):412-7. Epub 2012 Dec 6 doi: 10.1016/j.acthis.2012.10.001. PMID: 23219440
Gastric metastasis 14 years after mastectomy for breast lobular carcinoma: case report and literature review.
Aurello P, D'Angelo F, Cosenza G, Petrocca S, Stoppacciaro A, Ramacciato G, Ziparo V
Am Surg 2006 May;72(5):456-60. PMID: 16719204

Therapy

PET Imaging of (18)F-(2 S,4 R)4-Fluoroglutamine Accumulation in Breast Cancer: From Xenografts to Patients.
Liu F, Xu X, Zhu H, Zhang Y, Yang J, Zhang L, Li N, Zhu L, Kung HF, Yang Z
Mol Pharm 2018 Aug 6;15(8):3448-3455. Epub 2018 Jul 20 doi: 10.1021/acs.molpharmaceut.8b00430. PMID: 29985631
A digestive allergic reaction with hypereosinophilia imputable to docetaxel in a breast cancer patient: a case report.
Hamdan D, Leboeuf C, Pereira C, Jourdan N, Verneuil L, Bousquet G, Janin A
BMC Cancer 2015 Dec 21;15:993. doi: 10.1186/s12885-015-2008-0. PMID: 26810399Free PMC Article
UK national survey of management of breast lobular carcinoma in situ.
Chester R, Bokinni O, Ahmed I, Kasem A
Ann R Coll Surg Engl 2015 Nov;97(8):574-7. doi: 10.1308/rcsann.2015.0037. PMID: 26492902Free PMC Article
Metastatic breast lobular carcinoma to tamoxifen-associated endometrial polyp: case report and literature review.
Al-Brahim N, Elavathil LJ
Ann Diagn Pathol 2005 Jun;9(3):166-8. doi: 10.1016/j.anndiagpath.2005.03.003. PMID: 15944961
Metastatic breast lobular carcinoma involving tamoxifen-associated endometrial polyps: report of two cases and review of tamoxifen-associated polypoid uterine lesions.
Houghton JP, Ioffe OB, Silverberg SG, McGrady B, McCluggage WG
Mod Pathol 2003 Apr;16(4):395-8. doi: 10.1097/01.MP.0000062655.62606.86. PMID: 12692205

Prognosis

Cervical Squamous Carcinomas With Prominent Acantholysis and Areas Resembling Breast Lobular Carcinoma: An Aggressive Form of Dedifferentation.
Scott K, Bryson G, Jamison J, Coutts M, McCluggage WG
Int J Gynecol Pathol 2018 Jan;37(1):74-81. doi: 10.1097/PGP.0000000000000387. PMID: 28700422
Survivin expression in breast lobular carcinoma: correlations with normal breast tissue and clinicomorphological parameters.
Adamkov M, Výbohová D, Horáček J, Kovalská M, Furjelová M
Acta Histochem 2013 Jun;115(5):412-7. Epub 2012 Dec 6 doi: 10.1016/j.acthis.2012.10.001. PMID: 23219440
Anal metastasis from recurrent breast lobular carcinoma: a case report.
Puglisi M, Varaldo E, Assalino M, Ansaldo G, Torre G, Borgonovo G
World J Gastroenterol 2009 Mar 21;15(11):1388-90. doi: 10.3748/wjg.15.1388. PMID: 19294770Free PMC Article
Gastric metastases originating from occult breast lobular carcinoma: diagnostic and therapeutic problems.
Ciulla A, Castronovo G, Tomasello G, Maiorana AM, Russo L, Daniele E, Genova G
World J Surg Oncol 2008 Jul 25;6:78. doi: 10.1186/1477-7819-6-78. PMID: 18652707Free PMC Article
Breast lobular carcinoma in a fibroadenoma.
Betta PG, Cosimi MF
Eur J Surg Oncol 1985 Sep;11(3):283-5. PMID: 4029410

Clinical prediction guides

A digestive allergic reaction with hypereosinophilia imputable to docetaxel in a breast cancer patient: a case report.
Hamdan D, Leboeuf C, Pereira C, Jourdan N, Verneuil L, Bousquet G, Janin A
BMC Cancer 2015 Dec 21;15:993. doi: 10.1186/s12885-015-2008-0. PMID: 26810399Free PMC Article
Distribution of thrombospondin and integrin alpha V in DCIS, invasive ductal and lobular human breast carcinomas. Analysis by electron microscopy.
Serre CM, Clezardin P, Frappart L, Boivin G, Delmas PD
Virchows Arch 1995;427(4):365-72. doi: 10.1007/BF00199384. PMID: 8548120

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