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Abnormal T cell activation

MedGen UID:
1618255
•Concept ID:
C4531032
•
Cell or Molecular Dysfunction
Synonyms: Abnormal T lymphocyte activation; Abnormal T-cell activation; Abnormal T-lymphocyte activation
 
HPO: HP:0410035

Definition

Any abnormality in the activation of T cells, i.e. the change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [from HPO]

Professional guidelines

PubMed

Lipids in the tumor microenvironment: From cancer progression to treatment.
Corn KC, Windham MA, Rafat M
Prog Lipid Res 2020 Nov;80:101055. Epub 2020 Aug 11 doi: 10.1016/j.plipres.2020.101055. PMID: 32791170Free PMC Article
The role of alisertib in treatment of peripheral T-cell lymphomas.
Gallop-Evans E
Future Oncol 2015 Sep;11(18):2515-24. Epub 2015 Sep 7 doi: 10.2217/fon.15.154. PMID: 26344156
A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency.
Lee YN, Frugoni F, Dobbs K, Walter JE, Giliani S, Gennery AR, Al-Herz W, Haddad E, LeDeist F, Bleesing JH, Henderson LA, Pai SY, Nelson RP, El-Ghoneimy DH, El-Feky RA, Reda SM, Hossny E, Soler-Palacin P, Fuleihan RL, Patel NC, Massaad MJ, Geha RS, Puck JM, Palma P, Cancrini C, Chen K, Vihinen M, Alt FW, Notarangelo LD
J Allergy Clin Immunol 2014 Apr;133(4):1099-108. Epub 2013 Nov 28 doi: 10.1016/j.jaci.2013.10.007. PMID: 24290284Free PMC Article

Recent clinical studies

Etiology

Comparison of T-cell receptor diversity of people with myalgic encephalomyelitis versus controls.
Dibble JJ, Ferneyhough B, Roddis M, Millington S, Fischer MD, Parkinson NJ, Ponting CP
BMC Res Notes 2024 Jan 4;17(1):17. doi: 10.1186/s13104-023-06616-4. PMID: 38178251Free PMC Article
Elevated humoral response to cytomegalovirus in HIV-infected individuals with poor CD4+ T-cell immune recovery.
Gómez-Mora E, Massanella M, García E, Giles D, Bernadó M, Urrea V, Carrillo J, Ouchi D, Puig J, Negredo E, Clotet B, Blanco J, Cabrera C
PLoS One 2017;12(9):e0184433. Epub 2017 Sep 21 doi: 10.1371/journal.pone.0184433. PMID: 28934217Free PMC Article
Alternative expression pattern of MALT1-A20-NF-κB in patients with rheumatoid arthritis.
Wang X, Zhu L, Liao Z, Zhang F, Xu L, Xu Y, Chen S, Yang L, Zhou Y, Li Y
J Immunol Res 2014;2014:492872. Epub 2014 May 26 doi: 10.1155/2014/492872. PMID: 24971370Free PMC Article
Nephrotic syndrome associated with hemophagocytic syndrome.
Thaunat O, Delahousse M, Fakhouri F, Martinez F, Stephan JL, Noël LH, Karras A
Kidney Int 2006 May;69(10):1892-8. doi: 10.1038/sj.ki.5000352. PMID: 16557222
Abnormal T-cell activation in chronic hepatitis B viral infection: a consequence of monocyte dysfunction?
Nouri-Aria KT, Magrin S, Alexander GJ, Anderson MG, Williams R, Eddleston AL
Immunology 1988 Aug;64(4):733-8. PMID: 2971612Free PMC Article

Diagnosis

Comparison of T-cell receptor diversity of people with myalgic encephalomyelitis versus controls.
Dibble JJ, Ferneyhough B, Roddis M, Millington S, Fischer MD, Parkinson NJ, Ponting CP
BMC Res Notes 2024 Jan 4;17(1):17. doi: 10.1186/s13104-023-06616-4. PMID: 38178251Free PMC Article
Association between NKG2/KLR gene variants and epilepsy in Autism Spectrum Disorder.
Kaminski VL, Kulmann-Leal B, Tyska-Nunes GL, Beltrame BP, Riesgo RDS, Schüler-Faccini L, Roman T, Schuch JB, Chies JAB
J Neuroimmunol 2023 Aug 15;381:578132. Epub 2023 Jun 16 doi: 10.1016/j.jneuroim.2023.578132. PMID: 37352688
Case Report: X-Linked SASH3 Deficiency Presenting as a Common Variable Immunodeficiency.
Labrador-Horrillo M, Franco-Jarava C, Garcia-Prat M, Parra-Martínez A, Antolín M, Salgado-Perandrés S, Aguiló-Cucurull A, Martinez-Gallo M, Colobran R
Front Immunol 2022;13:881206. Epub 2022 Apr 8 doi: 10.3389/fimmu.2022.881206. PMID: 35464398Free PMC Article
Malignancy associated hemophagocytic lymphohistiocytosis in children.
Singh A, Dawman L, Seth R
J Cancer Res Ther 2018 Apr-Jun;14(3):559-562. doi: 10.4103/0973-1482.188437. PMID: 29893316
Nephrotic syndrome associated with hemophagocytic syndrome.
Thaunat O, Delahousse M, Fakhouri F, Martinez F, Stephan JL, Noël LH, Karras A
Kidney Int 2006 May;69(10):1892-8. doi: 10.1038/sj.ki.5000352. PMID: 16557222

Therapy

Elevated humoral response to cytomegalovirus in HIV-infected individuals with poor CD4+ T-cell immune recovery.
Gómez-Mora E, Massanella M, García E, Giles D, Bernadó M, Urrea V, Carrillo J, Ouchi D, Puig J, Negredo E, Clotet B, Blanco J, Cabrera C
PLoS One 2017;12(9):e0184433. Epub 2017 Sep 21 doi: 10.1371/journal.pone.0184433. PMID: 28934217Free PMC Article
The innate immune system in human systemic lupus erythematosus.
Weidenbusch M, Kulkarni OP, Anders HJ
Clin Sci (Lond) 2017 Apr 25;131(8):625-634. doi: 10.1042/CS20160415. PMID: 28351959
The inhibitor of costimulation of T cells: abatacept.
Iannone F, Lapadula G
J Rheumatol Suppl 2012 Jul;89:100-2. doi: 10.3899/jrheum.120257. PMID: 22751606
Dysfunctional B-cell responses during HIV-1 infection: implication for influenza vaccination and highly active antiretroviral therapy.
Cagigi A, Nilsson A, Pensieroso S, Chiodi F
Lancet Infect Dis 2010 Jul;10(7):499-503. doi: 10.1016/S1473-3099(10)70117-1. PMID: 20610332
Metabolic control of T cell activation and death in SLE.
Fernandez D, Perl A
Autoimmun Rev 2009 Jan;8(3):184-9. Epub 2008 Aug 21 doi: 10.1016/j.autrev.2008.07.041. PMID: 18722557Free PMC Article

Prognosis

Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individuals.
Chattopadhyay P, Khare K, Kumar M, Mishra P, Anand A, Maurya R, Gupta R, Sahni S, Gupta A, Wadhwa S, Yadav A, Devi P, Tardalkar K, Joshi M, Sethi T, Pandey R
Front Immunol 2022;13:1034159. Epub 2022 Dec 2 doi: 10.3389/fimmu.2022.1034159. PMID: 36532041Free PMC Article
Hemophagocytic Lymphohistiocytosis Associated With 2 Cases of Pediatric Lymphocyte-depleted Classic Hodgkin Lymphoma.
Cader FZ, Colmenero I, Mussai F
J Pediatr Hematol Oncol 2019 Jul;41(5):e341-e345. doi: 10.1097/MPH.0000000000001398. PMID: 30601404
Elevated humoral response to cytomegalovirus in HIV-infected individuals with poor CD4+ T-cell immune recovery.
Gómez-Mora E, Massanella M, García E, Giles D, Bernadó M, Urrea V, Carrillo J, Ouchi D, Puig J, Negredo E, Clotet B, Blanco J, Cabrera C
PLoS One 2017;12(9):e0184433. Epub 2017 Sep 21 doi: 10.1371/journal.pone.0184433. PMID: 28934217Free PMC Article
The innate immune system in human systemic lupus erythematosus.
Weidenbusch M, Kulkarni OP, Anders HJ
Clin Sci (Lond) 2017 Apr 25;131(8):625-634. doi: 10.1042/CS20160415. PMID: 28351959

Clinical prediction guides

Association between NKG2/KLR gene variants and epilepsy in Autism Spectrum Disorder.
Kaminski VL, Kulmann-Leal B, Tyska-Nunes GL, Beltrame BP, Riesgo RDS, Schüler-Faccini L, Roman T, Schuch JB, Chies JAB
J Neuroimmunol 2023 Aug 15;381:578132. Epub 2023 Jun 16 doi: 10.1016/j.jneuroim.2023.578132. PMID: 37352688
Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individuals.
Chattopadhyay P, Khare K, Kumar M, Mishra P, Anand A, Maurya R, Gupta R, Sahni S, Gupta A, Wadhwa S, Yadav A, Devi P, Tardalkar K, Joshi M, Sethi T, Pandey R
Front Immunol 2022;13:1034159. Epub 2022 Dec 2 doi: 10.3389/fimmu.2022.1034159. PMID: 36532041Free PMC Article
Elevated humoral response to cytomegalovirus in HIV-infected individuals with poor CD4+ T-cell immune recovery.
Gómez-Mora E, Massanella M, García E, Giles D, Bernadó M, Urrea V, Carrillo J, Ouchi D, Puig J, Negredo E, Clotet B, Blanco J, Cabrera C
PLoS One 2017;12(9):e0184433. Epub 2017 Sep 21 doi: 10.1371/journal.pone.0184433. PMID: 28934217Free PMC Article
Nitric oxide-dependent mitochondrial biogenesis generates Ca2+ signaling profile of lupus T cells.
Nagy G, Barcza M, Gonchoroff N, Phillips PE, Perl A
J Immunol 2004 Sep 15;173(6):3676-83. doi: 10.4049/jimmunol.173.6.3676. PMID: 15356113Free PMC Article
Abnormal T cell activation and skewed T cell receptor V beta repertoire usage in Japanese patients with idiopathic portal hypertension.
Tokushige K, Hirose S, Nishimura H, Fujimori M, Yamauchi K, Obata H, Futagawa S, Shirai T
Clin Immunol Immunopathol 1995 Jun;75(3):206-13. doi: 10.1006/clin.1995.1073. PMID: 7768038

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