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Decreased CD25 upregulation upon TCR activation

MedGen UID:
1621840
•Concept ID:
C4531234
•
Cell or Molecular Dysfunction
Synonyms: Poor CD25 upregulation upon TCR activation; Reduced IL2RA upregulation upon TCR activation
 
HPO: HP:0031270

Definition

Decreased or impaired upregulation of CD25 on T cells after activation via the T cell receptor (TCR). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased CD25 upregulation upon TCR activation

Recent clinical studies

Etiology

In vitro engagement of CD3 and CD28 corrects T cell defects in chronic lymphocytic leukemia.
Bonyhadi M, Frohlich M, Rasmussen A, Ferrand C, Grosmaire L, Robinet E, Leis J, Maziarz RT, Tiberghien P, Berenson RJ
J Immunol 2005 Feb 15;174(4):2366-75. doi: 10.4049/jimmunol.174.4.2366. PMID: 15699173

Therapy

Potential therapeutic effect of low-dose paclitaxel in melanoma patients resistant to immune checkpoint blockade: A pilot study.
Gebhardt C, Simon SCS, Weber R, Gries M, Mun DH, Reinhard R, Holland-Letz T, Umansky V, Utikal J
Cell Immunol 2021 Feb;360:104274. Epub 2020 Dec 28 doi: 10.1016/j.cellimm.2020.104274. PMID: 33383383
In vitro engagement of CD3 and CD28 corrects T cell defects in chronic lymphocytic leukemia.
Bonyhadi M, Frohlich M, Rasmussen A, Ferrand C, Grosmaire L, Robinet E, Leis J, Maziarz RT, Tiberghien P, Berenson RJ
J Immunol 2005 Feb 15;174(4):2366-75. doi: 10.4049/jimmunol.174.4.2366. PMID: 15699173
Non FcR-binding murine antihuman CD3 monoclonal antibody is capable of productive TCR signalling and induces proliferation in the presence of costimulation.
Meijer RT, Yong SL, ten Berge IJ, van Lier RA, Schellekens PT
Clin Exp Immunol 2001 Mar;123(3):511-9. doi: 10.1046/j.1365-2249.2001.01464.x. PMID: 11298141Free PMC Article

Prognosis

Exogenous immunoglobulin downregulates T-cell receptor signaling and cytokine production.
Tawfik DS, Cowan KR, Walsh AM, Hamilton WS, Goldman FD
Pediatr Allergy Immunol 2012 Feb;23(1):88-95. Epub 2011 Jan 25 doi: 10.1111/j.1399-3038.2010.01129.x. PMID: 21265884

Clinical prediction guides

CD4+ T cells from patients with primary sclerosing cholangitis exhibit reduced apoptosis and down-regulation of proapoptotic Bim in peripheral blood.
Schoknecht T, Schwinge D, Stein S, Weiler-Normann C, Sebode M, Mucha S, Otto B, Ellinghaus E, Stahl F, Franke A, Lohse AW, Herkel J, Schramm C
J Leukoc Biol 2017 Feb;101(2):589-597. Epub 2016 Sep 14 doi: 10.1189/jlb.5A1015-469R. PMID: 27630216
Non FcR-binding murine antihuman CD3 monoclonal antibody is capable of productive TCR signalling and induces proliferation in the presence of costimulation.
Meijer RT, Yong SL, ten Berge IJ, van Lier RA, Schellekens PT
Clin Exp Immunol 2001 Mar;123(3):511-9. doi: 10.1046/j.1365-2249.2001.01464.x. PMID: 11298141Free PMC Article

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