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Lung Squamous Cell Carcinoma In Situ

MedGen UID:
1625266
•Concept ID:
C4526917
•
Neoplastic Process
Synonym: Squamous Cell Lung Carcinoma In Situ

Definition

A preinvasive bronchial neoplastic lesion affecting the squamous epithelium. It is characterized by the absence of progression of maturation from base to luminal surface, basilar zone expansion with cellular crowding throughout the epithelium, absence of the intermediate zone, and surface flattening confined to the most superficial cells. The nuclear-to-cytoplasmic ratio is often high and variable, the chromatin is coarse and uneven, and mitotic figures are present through full thickness. The cell size may be markedly increased. Anisocytosis and pleomorphism may be present. (Adapted from WHO, 2015) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Squamous Cell Carcinoma In Situ

Professional guidelines

PubMed

Deepening the Knowledge of ROS1 Rearrangements in Non-Small Cell Lung Cancer: Diagnosis, Treatment, Resistance and Concomitant Alterations.
Guaitoli G, Bertolini F, Bettelli S, Manfredini S, Maur M, Trudu L, Aramini B, Masciale V, Grisendi G, Dominici M, Barbieri F
Int J Mol Sci 2021 Nov 28;22(23) doi: 10.3390/ijms222312867. PMID: 34884672Free PMC Article
Genetic screening and molecular characterization of MET alterations in non-small cell lung cancer.
Saigi M, McLeer-Florin A, Pros E, Nadal E, Brambilla E, Sanchez-Cespedes M
Clin Transl Oncol 2018 Jul;20(7):881-888. Epub 2017 Nov 14 doi: 10.1007/s12094-017-1799-7. PMID: 29139039
Early detection, diagnosis, and management of oral and oropharyngeal cancer.
Mashberg A, Samit AM
CA Cancer J Clin 1989 Mar-Apr;39(2):67-88. doi: 10.3322/canjclin.39.2.67. PMID: 2495159

Recent clinical studies

Etiology

The role of Hippo-YAP signaling in squamous cell carcinomas.
Maehama T, Nishio M, Otani J, Mak TW, Suzuki A
Cancer Sci 2021 Jan;112(1):51-60. Epub 2020 Dec 9 doi: 10.1111/cas.14725. PMID: 33159406Free PMC Article
Interaction between the microbiome and TP53 in human lung cancer.
Greathouse KL, White JR, Vargas AJ, Bliskovsky VV, Beck JA, von Muhlinen N, Polley EC, Bowman ED, Khan MA, Robles AI, Cooks T, Ryan BM, Padgett N, Dzutsev AH, Trinchieri G, Pineda MA, Bilke S, Meltzer PS, Hokenstad AN, Stickrod TM, Walther-Antonio MR, Earl JP, Mell JC, Krol JE, Balashov SV, Bhat AS, Ehrlich GD, Valm A, Deming C, Conlan S, Oh J, Segre JA, Harris CC
Genome Biol 2018 Aug 24;19(1):123. doi: 10.1186/s13059-018-1501-6. PMID: 30143034Free PMC Article
Preinvasive disease of the airway.
Thakrar RM, Pennycuick A, Borg E, Janes SM
Cancer Treat Rev 2017 Jul;58:77-90. Epub 2017 Jul 10 doi: 10.1016/j.ctrv.2017.05.009. PMID: 28704777
Lung cancer chemoprevention.
Keith RL
Proc Am Thorac Soc 2012 May;9(2):52-6. doi: 10.1513/pats.201107-038MS. PMID: 22550242Free PMC Article
Pulmonary preinvasive neoplasia.
Kerr KM
J Clin Pathol 2001 Apr;54(4):257-71. doi: 10.1136/jcp.54.4.257. PMID: 11304841Free PMC Article

Diagnosis

Interaction between the microbiome and TP53 in human lung cancer.
Greathouse KL, White JR, Vargas AJ, Bliskovsky VV, Beck JA, von Muhlinen N, Polley EC, Bowman ED, Khan MA, Robles AI, Cooks T, Ryan BM, Padgett N, Dzutsev AH, Trinchieri G, Pineda MA, Bilke S, Meltzer PS, Hokenstad AN, Stickrod TM, Walther-Antonio MR, Earl JP, Mell JC, Krol JE, Balashov SV, Bhat AS, Ehrlich GD, Valm A, Deming C, Conlan S, Oh J, Segre JA, Harris CC
Genome Biol 2018 Aug 24;19(1):123. doi: 10.1186/s13059-018-1501-6. PMID: 30143034Free PMC Article
The IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer.
Travis WD, Asamura H, Bankier AA, Beasley MB, Detterbeck F, Flieder DB, Goo JM, MacMahon H, Naidich D, Nicholson AG, Powell CA, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
J Thorac Oncol 2016 Aug;11(8):1204-1223. Epub 2016 Apr 21 doi: 10.1016/j.jtho.2016.03.025. PMID: 27107787
Lung cancer chemoprevention.
Keith RL
Proc Am Thorac Soc 2012 May;9(2):52-6. doi: 10.1513/pats.201107-038MS. PMID: 22550242Free PMC Article
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Cytopathologic diagnosis of lung cancer.
Erozan YS, Frost JK
Semin Oncol 1974 Sep;1(3):191-8. PMID: 4620432

Therapy

New targets bring hope in squamous cell lung cancer: neurotrophic tyrosine kinase gene fusions.
Rolfo C, Raez L
Lab Invest 2017 Nov;97(11):1268-1270. doi: 10.1038/labinvest.2017.91. PMID: 29085074
Preinvasive disease of the airway.
Thakrar RM, Pennycuick A, Borg E, Janes SM
Cancer Treat Rev 2017 Jul;58:77-90. Epub 2017 Jul 10 doi: 10.1016/j.ctrv.2017.05.009. PMID: 28704777
Lung cancer chemoprevention.
Keith RL
Proc Am Thorac Soc 2012 May;9(2):52-6. doi: 10.1513/pats.201107-038MS. PMID: 22550242Free PMC Article
KRAS-mutation positive, metastatic tonsil carcinoma with cancer stem-like cell features and long-term response to gefitinib: a case report and review of the literature.
Gottschling S, Penzel R, Pelz T, Herpel E, Schnabel PA, Dyckhoff G, Thomas M, Kuhnt T
J Clin Oncol 2011 Jul 20;29(21):e616-9. Epub 2011 May 9 doi: 10.1200/JCO.2011.34.5892. PMID: 21555681
Lung cancer preneoplasia.
Wistuba II, Gazdar AF
Annu Rev Pathol 2006;1:331-48. doi: 10.1146/annurev.pathol.1.110304.100103. PMID: 18039118

Prognosis

Molecular profiling of human non-small cell lung cancer by single-cell RNA-seq.
Li Q, Wang R, Yang Z, Li W, Yang J, Wang Z, Bai H, Cui Y, Tian Y, Wu Z, Guo Y, Xu J, Wen L, He J, Tang F, Wang J
Genome Med 2022 Aug 13;14(1):87. doi: 10.1186/s13073-022-01089-9. PMID: 35962452Free PMC Article
Preinvasive disease of the airway.
Thakrar RM, Pennycuick A, Borg E, Janes SM
Cancer Treat Rev 2017 Jul;58:77-90. Epub 2017 Jul 10 doi: 10.1016/j.ctrv.2017.05.009. PMID: 28704777
The IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer.
Travis WD, Asamura H, Bankier AA, Beasley MB, Detterbeck F, Flieder DB, Goo JM, MacMahon H, Naidich D, Nicholson AG, Powell CA, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
J Thorac Oncol 2016 Aug;11(8):1204-1223. Epub 2016 Apr 21 doi: 10.1016/j.jtho.2016.03.025. PMID: 27107787
KRAS-mutation positive, metastatic tonsil carcinoma with cancer stem-like cell features and long-term response to gefitinib: a case report and review of the literature.
Gottschling S, Penzel R, Pelz T, Herpel E, Schnabel PA, Dyckhoff G, Thomas M, Kuhnt T
J Clin Oncol 2011 Jul 20;29(21):e616-9. Epub 2011 May 9 doi: 10.1200/JCO.2011.34.5892. PMID: 21555681
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Clinical prediction guides

An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers.
Mezheyeuski A, Backman M, Mattsson J, Martín-Bernabé A, Larsson C, Hrynchyk I, Hammarström K, Ström S, Ekström J, Mauchanski S, Khelashvili S, Lindberg A, Agnarsdóttir M, Edqvist PH, Huvila J, Segersten U, Malmström PU, Botling J, Nodin B, Hedner C, Borg D, Brändstedt J, Sartor H, Leandersson K, Glimelius B, Portyanko A, Ponten F, Jirström K, Micke P, Sjöblom T
EBioMedicine 2023 Feb;88:104452. Epub 2023 Jan 30 doi: 10.1016/j.ebiom.2023.104452. PMID: 36724681Free PMC Article
Smurf2 inhibition enhances chemotherapy and radiation sensitivity in non-small-cell lung cancer.
Chaudhary KR, Kinslow CJ, Cheng H, Silva JM, Yu J, Wang TJ, Hei TK, Halmos B, Cheng SK
Sci Rep 2022 Jun 16;12(1):10140. doi: 10.1038/s41598-022-14448-8. PMID: 35710591Free PMC Article
Preinvasive disease of the airway.
Thakrar RM, Pennycuick A, Borg E, Janes SM
Cancer Treat Rev 2017 Jul;58:77-90. Epub 2017 Jul 10 doi: 10.1016/j.ctrv.2017.05.009. PMID: 28704777
The IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer.
Travis WD, Asamura H, Bankier AA, Beasley MB, Detterbeck F, Flieder DB, Goo JM, MacMahon H, Naidich D, Nicholson AG, Powell CA, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y; International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
J Thorac Oncol 2016 Aug;11(8):1204-1223. Epub 2016 Apr 21 doi: 10.1016/j.jtho.2016.03.025. PMID: 27107787
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Recent systematic reviews

International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society: international multidisciplinary classification of lung adenocarcinoma: executive summary.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger K, Yatabe Y, Powell CA, Beer D, Riely G, Garg K, Austin JH, Rusch VW, Hirsch FR, Jett J, Yang PC, Gould M; American Thoracic Society
Proc Am Thorac Soc 2011 Sep;8(5):381-5. doi: 10.1513/pats.201107-042ST. PMID: 21926387
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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