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High Grade Intraepithelial Neoplasia

MedGen UID:
234349
•Concept ID:
C1334015
•
Neoplastic Process

Definition

A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. According to the degree of nuclear atypia, number of mitotic figures, and presence of architectural distortion, it is classified as grade II (moderate dysplasia) or grade III (severe dysplasia). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Grade Intraepithelial Neoplasia

Professional guidelines

PubMed

Updated German guideline on diagnosis and treatment of squamous cell carcinoma and adenocarcinoma of the esophagus.
Porschen R, Fischbach W, Gockel I, Hollerbach S, Hölscher A, Jansen PL, Miehlke S, Pech O, Stahl M, Vanhoefer U, Ebert MPA
United European Gastroenterol J 2024 Apr;12(3):399-411. Epub 2024 Jan 29 doi: 10.1002/ueg2.12523. PMID: 38284661Free PMC Article
Expected value of artificial intelligence in gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.
Messmann H, Bisschops R, Antonelli G, Libânio D, Sinonquel P, Abdelrahim M, Ahmad OF, Areia M, Bergman JJGHM, Bhandari P, Boskoski I, Dekker E, Domagk D, Ebigbo A, Eelbode T, Eliakim R, Häfner M, Haidry RJ, Jover R, Kaminski MF, Kuvaev R, Mori Y, Palazzo M, Repici A, Rondonotti E, Rutter MD, Saito Y, Sharma P, Spada C, Spadaccini M, Veitch A, Gralnek IM, Hassan C, Dinis-Ribeiro M
Endoscopy 2022 Dec;54(12):1211-1231. Epub 2022 Oct 21 doi: 10.1055/a-1950-5694. PMID: 36270318
The current recommendation for the management of isolated high-grade prostatic intraepithelial neoplasia.
Morote J, Schwartzmann I, Celma A, Roche S, de Torres IM, Mast R, Semidey ME, Regis L, Santamaria A, Planas J, Trilla E
BJU Int 2022 May;129(5):627-633. Epub 2021 Aug 25 doi: 10.1111/bju.15568. PMID: 34375498

Recent clinical studies

Etiology

Characteristics of multiple early gastric cancer and gastric high-grade intraepithelial neoplasia.
Chen Y, He L, Zheng X
Medicine (Baltimore) 2023 Dec 8;102(49):e36439. doi: 10.1097/MD.0000000000036439. PMID: 38065868Free PMC Article
Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer.
Liu X, Zhao S, Wang K, Zhou L, Jiang M, Gao Y, Yang R, Yan S, Zhang W, Lu B, Liu F, Zhao R, Liu W, Zhang Z, Liu K, Li X, Dong Z
Nat Commun 2023 Aug 8;14(1):4779. doi: 10.1038/s41467-023-40343-5. PMID: 37553345Free PMC Article
Machine learning-based automated sponge cytology for screening of oesophageal squamous cell carcinoma and adenocarcinoma of the oesophagogastric junction: a nationwide, multicohort, prospective study.
Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou AJ, Huang S, Wang JH, Feng YD, Yao SH, Guo Y, Dang T, Meng XM, Yang ZZ, Jia WQ, Pang HF, Tian XJ, Deng B, Wang JP, Fan WC, Wang J, Shi LH, Yang GY, Sun C, Wang W, Zang JC, Li SY, Shi RH, Li ZS, Wang LW
Lancet Gastroenterol Hepatol 2023 May;8(5):432-445. Epub 2023 Mar 14 doi: 10.1016/S2468-1253(23)00004-3. PMID: 36931287
Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer.
Huang S, Guo Y, Li ZW, Shui G, Tian H, Li BW, Kadeerhan G, Li ZX, Li X, Zhang Y, Zhou T, You WC, Pan KF, Li WQ
JAMA Netw Open 2021 Jun 1;4(6):e2114186. doi: 10.1001/jamanetworkopen.2021.14186. PMID: 34156450Free PMC Article
Radiofrequency ablation for Barrett's esophagus-related neoplasia.
Krajciova J, Vackova Z, Spicak J, Martinek J
Minerva Chir 2018 Aug;73(4):366-377. Epub 2018 May 25 doi: 10.23736/S0026-4733.18.07783-0. PMID: 29806757

Diagnosis

Machine learning-based automated sponge cytology for screening of oesophageal squamous cell carcinoma and adenocarcinoma of the oesophagogastric junction: a nationwide, multicohort, prospective study.
Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou AJ, Huang S, Wang JH, Feng YD, Yao SH, Guo Y, Dang T, Meng XM, Yang ZZ, Jia WQ, Pang HF, Tian XJ, Deng B, Wang JP, Fan WC, Wang J, Shi LH, Yang GY, Sun C, Wang W, Zang JC, Li SY, Shi RH, Li ZS, Wang LW
Lancet Gastroenterol Hepatol 2023 May;8(5):432-445. Epub 2023 Mar 14 doi: 10.1016/S2468-1253(23)00004-3. PMID: 36931287
Expected value of artificial intelligence in gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.
Messmann H, Bisschops R, Antonelli G, Libânio D, Sinonquel P, Abdelrahim M, Ahmad OF, Areia M, Bergman JJGHM, Bhandari P, Boskoski I, Dekker E, Domagk D, Ebigbo A, Eelbode T, Eliakim R, Häfner M, Haidry RJ, Jover R, Kaminski MF, Kuvaev R, Mori Y, Palazzo M, Repici A, Rondonotti E, Rutter MD, Saito Y, Sharma P, Spada C, Spadaccini M, Veitch A, Gralnek IM, Hassan C, Dinis-Ribeiro M
Endoscopy 2022 Dec;54(12):1211-1231. Epub 2022 Oct 21 doi: 10.1055/a-1950-5694. PMID: 36270318
Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer.
Huang S, Guo Y, Li ZW, Shui G, Tian H, Li BW, Kadeerhan G, Li ZX, Li X, Zhang Y, Zhou T, You WC, Pan KF, Li WQ
JAMA Netw Open 2021 Jun 1;4(6):e2114186. doi: 10.1001/jamanetworkopen.2021.14186. PMID: 34156450Free PMC Article
A Tubulovillous Adenoma With High-Grade Intraepithelial Neoplasia in Upper Barrett's Esophagus.
Long Y, Lv X, Tang L, Yang J
Am J Gastroenterol 2021 Apr;116(4):628. doi: 10.14309/ajg.0000000000000736. PMID: 33982920
Endoscopic submucosal dissection of high grade intraepithelial neoplasia of the head and neck in a patient after surgical resection of esophageal cancer.
He YQ, Li AQ, Wang X, Fu KI, Sheng JQ
Endoscopy 2015;47 Suppl 1 UCTN:E49-50. Epub 2015 Feb 17 doi: 10.1055/s-0034-1365429. PMID: 25926205

Therapy

Disruption of the gastric epithelial barrier in Correa's cascade: Clinical evidence via confocal endomicroscopy.
Wang ST, Yang HW, Zhang WL, Li Z, Ji R
Helicobacter 2024 Mar-Apr;29(2):e13065. doi: 10.1111/hel.13065. PMID: 38443332
Characteristic analysis of early gastric cancer after Helicobacter pylori eradication: a multicenter retrospective propensity score-matched study.
Liu X, Wang X, Mao T, Yin X, Wei Z, Fu J, Wu J, Li X
Ann Med 2023 Dec;55(1):2231852. doi: 10.1080/07853890.2023.2231852. PMID: 37450336Free PMC Article
Histopathological Characteristics and Therapeutic Outcomes of Endoscopic Submucosal Dissection for Gastric High-Grade Intraepithelial Neoplasia.
Zhang HH, Soyfoo MD, Cao JL, Sang HM, Xu SF, Jiang JX
J Laparoendosc Adv Surg Tech A 2022 Apr;32(4):413-421. Epub 2021 Dec 28 doi: 10.1089/lap.2020.0035. PMID: 34962142
The risk factors for delayed bleeding after endoscopic resection of colorectal tumors: a meta-analysis.
Xu Y, Zhong S, Liang W, Lin XL
Expert Rev Gastroenterol Hepatol 2020 Nov;14(11):1083-1092. Epub 2020 Aug 12 doi: 10.1080/17474124.2020.1801416. PMID: 32721191
Clinical relevance and implications of HPV-induced neoplasia in different anatomical locations.
Prigge ES, von Knebel Doeberitz M, Reuschenbach M
Mutat Res Rev Mutat Res 2017 Apr-Jun;772:51-66. Epub 2016 Jun 22 doi: 10.1016/j.mrrev.2016.06.005. PMID: 28528690

Prognosis

Updated German guideline on diagnosis and treatment of squamous cell carcinoma and adenocarcinoma of the esophagus.
Porschen R, Fischbach W, Gockel I, Hollerbach S, Hölscher A, Jansen PL, Miehlke S, Pech O, Stahl M, Vanhoefer U, Ebert MPA
United European Gastroenterol J 2024 Apr;12(3):399-411. Epub 2024 Jan 29 doi: 10.1002/ueg2.12523. PMID: 38284661Free PMC Article
Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer.
Liu X, Zhao S, Wang K, Zhou L, Jiang M, Gao Y, Yang R, Yan S, Zhang W, Lu B, Liu F, Zhao R, Liu W, Zhang Z, Liu K, Li X, Dong Z
Nat Commun 2023 Aug 8;14(1):4779. doi: 10.1038/s41467-023-40343-5. PMID: 37553345Free PMC Article
Machine learning-based automated sponge cytology for screening of oesophageal squamous cell carcinoma and adenocarcinoma of the oesophagogastric junction: a nationwide, multicohort, prospective study.
Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou AJ, Huang S, Wang JH, Feng YD, Yao SH, Guo Y, Dang T, Meng XM, Yang ZZ, Jia WQ, Pang HF, Tian XJ, Deng B, Wang JP, Fan WC, Wang J, Shi LH, Yang GY, Sun C, Wang W, Zang JC, Li SY, Shi RH, Li ZS, Wang LW
Lancet Gastroenterol Hepatol 2023 May;8(5):432-445. Epub 2023 Mar 14 doi: 10.1016/S2468-1253(23)00004-3. PMID: 36931287
Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer.
Huang S, Guo Y, Li ZW, Shui G, Tian H, Li BW, Kadeerhan G, Li ZX, Li X, Zhang Y, Zhou T, You WC, Pan KF, Li WQ
JAMA Netw Open 2021 Jun 1;4(6):e2114186. doi: 10.1001/jamanetworkopen.2021.14186. PMID: 34156450Free PMC Article
Abnormal cytology in 2012: management of atypical squamous cells, low-grade intraepithelial neoplasia, and high-grade intraepithelial neoplasia.
Garrett LA, McCann CK
Clin Obstet Gynecol 2013 Mar;56(1):25-34. doi: 10.1097/GRF.0b013e3182833eed. PMID: 23337842

Clinical prediction guides

Disruption of the gastric epithelial barrier in Correa's cascade: Clinical evidence via confocal endomicroscopy.
Wang ST, Yang HW, Zhang WL, Li Z, Ji R
Helicobacter 2024 Mar-Apr;29(2):e13065. doi: 10.1111/hel.13065. PMID: 38443332
Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer.
Liu X, Zhao S, Wang K, Zhou L, Jiang M, Gao Y, Yang R, Yan S, Zhang W, Lu B, Liu F, Zhao R, Liu W, Zhang Z, Liu K, Li X, Dong Z
Nat Commun 2023 Aug 8;14(1):4779. doi: 10.1038/s41467-023-40343-5. PMID: 37553345Free PMC Article
Machine learning-based automated sponge cytology for screening of oesophageal squamous cell carcinoma and adenocarcinoma of the oesophagogastric junction: a nationwide, multicohort, prospective study.
Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou AJ, Huang S, Wang JH, Feng YD, Yao SH, Guo Y, Dang T, Meng XM, Yang ZZ, Jia WQ, Pang HF, Tian XJ, Deng B, Wang JP, Fan WC, Wang J, Shi LH, Yang GY, Sun C, Wang W, Zang JC, Li SY, Shi RH, Li ZS, Wang LW
Lancet Gastroenterol Hepatol 2023 May;8(5):432-445. Epub 2023 Mar 14 doi: 10.1016/S2468-1253(23)00004-3. PMID: 36931287
Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer.
Huang S, Guo Y, Li ZW, Shui G, Tian H, Li BW, Kadeerhan G, Li ZX, Li X, Zhang Y, Zhou T, You WC, Pan KF, Li WQ
JAMA Netw Open 2021 Jun 1;4(6):e2114186. doi: 10.1001/jamanetworkopen.2021.14186. PMID: 34156450Free PMC Article
High-grade anal intraepithelial neoplasia: Progression to invasive cancer is not a certainty.
Gautier M, Brochard C, Lion A, Henno S, Mallet AL, Bodere A, Bouguen G, Lièvre A, Siproudhis L
Dig Liver Dis 2016 Jul;48(7):806-11. Epub 2016 Mar 28 doi: 10.1016/j.dld.2016.03.011. PMID: 27103359

Recent systematic reviews

The Application of Core Needle Biopsy Through the Trocar Hole in the Surgical Operation of Endoscopically Unresectable Giant Colon Polyps: A Systematic Review Study.
Kang CB, Li XB, Hou S, Zhang J, Chi XQ, Shan HF, Zhang QJ, Liu TJ
Adv Ther 2021 May;38(5):2662-2672. Epub 2021 Apr 17 doi: 10.1007/s12325-021-01635-8. PMID: 33864202
The risk factors for delayed bleeding after endoscopic resection of colorectal tumors: a meta-analysis.
Xu Y, Zhong S, Liang W, Lin XL
Expert Rev Gastroenterol Hepatol 2020 Nov;14(11):1083-1092. Epub 2020 Aug 12 doi: 10.1080/17474124.2020.1801416. PMID: 32721191
High-risk HPV testing in the management of atypical glandular cells: A systematic review and meta-analysis.
Verdoodt F, Jiang X, Williams M, Schnatz PF, Arbyn M
Int J Cancer 2016 Jan 15;138(2):303-10. Epub 2015 Feb 5 doi: 10.1002/ijc.29424. PMID: 25583258
Systematic review and meta-analysis of endoscopic ablative treatment of Barrett's esophagus.
De Souza TF, Artifon EL, Mestieri LH, Reimão SM, Aires FT, Bernardo WM, Otoch JP, De Moura EG
Rev Gastroenterol Peru 2014 Jul;34(3):217-24. PMID: 25293990

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