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Optic pathway glioma

MedGen UID:
162950
•Concept ID:
C0796418
•
Neoplastic Process
Synonyms: glioma of optic tract; glioma of the optic tract; Glioma of the Visual Pathway; glioma of the visual pathway; Glioma of Visual Pathway; glioma of visual pathway; Optic Pathway Glioma; optic pathway glioma; optic tract glioma; Visual Pathway Glioma; visual pathway glioma
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0016167
Orphanet: ORPHA2086

Definition

Optic pathway glioma (OPG) is a benign tumor that develop along the optic nerve (chiasm, tracts, and radiations) characterized by impairment or loss of vision and may be accompanied by diencephalic symptoms such as reduced growth and alteration in sleeping patterns. OPG are often linked to neurofibromatosis type 1 (NF1, see this term). [from ORDO]

Professional guidelines

PubMed

The management of neurofibromatosis type 1 (NF1) in children and adolescents.
Kerashvili N, Gutmann DH
Expert Rev Neurother 2024 Apr;24(4):409-420. Epub 2024 Feb 27 doi: 10.1080/14737175.2024.2324117. PMID: 38406862
Neurofibromatosis type 1 (NF1): diagnosis and management.
Ferner RE, Gutmann DH
Handb Clin Neurol 2013;115:939-55. doi: 10.1016/B978-0-444-52902-2.00053-9. PMID: 23931823
Optic pathway gliomas in children with neurofibromatosis 1: consensus statement from the NF1 Optic Pathway Glioma Task Force.
Listernick R, Louis DN, Packer RJ, Gutmann DH
Ann Neurol 1997 Feb;41(2):143-9. doi: 10.1002/ana.410410204. PMID: 9029062

Recent clinical studies

Etiology

The management of neurofibromatosis type 1 (NF1) in children and adolescents.
Kerashvili N, Gutmann DH
Expert Rev Neurother 2024 Apr;24(4):409-420. Epub 2024 Feb 27 doi: 10.1080/14737175.2024.2324117. PMID: 38406862
Neurofibromatosis in the Era of Precision Medicine: Development of MEK Inhibitors and Recent Successes with Selumetinib.
Galvin R, Watson AL, Largaespada DA, Ratner N, Osum S, Moertel CL
Curr Oncol Rep 2021 Mar 15;23(4):45. doi: 10.1007/s11912-021-01032-y. PMID: 33721151Free PMC Article
Neurofibromatosis Type 1-Related Hydrocephalus: Treatment Options and Considerations.
Roth J, Ber R, Constantini S
World Neurosurg 2019 Aug;128:e664-e668. Epub 2019 May 3 doi: 10.1016/j.wneu.2019.04.231. PMID: 31059857
Neurofibromatosis type 1.
Anderson JL, Gutmann DH
Handb Clin Neurol 2015;132:75-86. doi: 10.1016/B978-0-444-62702-5.00004-4. PMID: 26564071
Nonmalignant pediatric brain tumors.
Rashidi M, DaSilva VR, Minagar A, Rutka JT
Curr Neurol Neurosci Rep 2003 May;3(3):200-5. doi: 10.1007/s11910-003-0079-9. PMID: 12691624

Diagnosis

The management of neurofibromatosis type 1 (NF1) in children and adolescents.
Kerashvili N, Gutmann DH
Expert Rev Neurother 2024 Apr;24(4):409-420. Epub 2024 Feb 27 doi: 10.1080/14737175.2024.2324117. PMID: 38406862
Pediatric Optic Pathway/Hypothalamic Glioma.
Aihara Y, Chiba K, Eguchi S, Amano K, Kawamata T
Neurol Med Chir (Tokyo) 2018 Jan 15;58(1):1-9. Epub 2017 Nov 9 doi: 10.2176/nmc.ra.2017-0081. PMID: 29118304Free PMC Article
Eliminating barriers to personalized medicine: learning from neurofibromatosis type 1.
Gutmann DH
Neurology 2014 Jul 29;83(5):463-71. Epub 2014 Jun 27 doi: 10.1212/WNL.0000000000000652. PMID: 24975854Free PMC Article
Neurofibromatosis type 1 (NF1): diagnosis and management.
Ferner RE, Gutmann DH
Handb Clin Neurol 2013;115:939-55. doi: 10.1016/B978-0-444-52902-2.00053-9. PMID: 23931823
Nonmalignant pediatric brain tumors.
Rashidi M, DaSilva VR, Minagar A, Rutka JT
Curr Neurol Neurosci Rep 2003 May;3(3):200-5. doi: 10.1007/s11910-003-0079-9. PMID: 12691624

Therapy

Neurofibromatosis type 1-associated optic pathway gliomas: pathogenesis and emerging treatments.
Amato A, Imbimbo BP, Falsini B
Eur Rev Med Pharmacol Sci 2023 Jun;27(12):5636-5653. doi: 10.26355/eurrev_202306_32804. PMID: 37401302
A phase II trial of selumetinib in children with recurrent optic pathway and hypothalamic low-grade glioma without NF1: a Pediatric Brain Tumor Consortium study.
Fangusaro J, Onar-Thomas A, Poussaint TY, Wu S, Ligon AH, Lindeman N, Campagne O, Banerjee A, Gururangan S, Kilburn LB, Goldman S, Qaddoumi I, Baxter P, Vezina G, Bregman C, Patay Z, Jones JY, Stewart CF, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Neuro Oncol 2021 Oct 1;23(10):1777-1788. doi: 10.1093/neuonc/noab047. PMID: 33631016Free PMC Article
Bevacizumab for optic pathway glioma with worsening visual field in absence of imaging progression: 2 case reports and literature review.
Yamasaki F, Takano M, Yonezawa U, Taguchi A, Kolakshyapati M, Okumichi H, Kiuchi Y, Kurisu K
Childs Nerv Syst 2020 Mar;36(3):635-639. Epub 2019 Nov 7 doi: 10.1007/s00381-019-04407-6. PMID: 31701281
Phase II Weekly Vinblastine for Chemotherapy-Naïve Children With Progressive Low-Grade Glioma: A Canadian Pediatric Brain Tumor Consortium Study.
Lassaletta A, Scheinemann K, Zelcer SM, Hukin J, Wilson BA, Jabado N, Carret AS, Lafay-Cousin L, Larouche V, Hawkins CE, Pond GR, Poskitt K, Keene D, Johnston DL, Eisenstat DD, Krishnatry R, Mistry M, Arnoldo A, Ramaswamy V, Huang A, Bartels U, Tabori U, Bouffet E
J Clin Oncol 2016 Oct 10;34(29):3537-3543. doi: 10.1200/JCO.2016.68.1585. PMID: 27573663
Eliminating barriers to personalized medicine: learning from neurofibromatosis type 1.
Gutmann DH
Neurology 2014 Jul 29;83(5):463-71. Epub 2014 Jun 27 doi: 10.1212/WNL.0000000000000652. PMID: 24975854Free PMC Article

Prognosis

The Present and Future of Optic Pathway Glioma Therapy.
Dal Bello S, Martinuzzi D, Tereshko Y, Veritti D, Sarao V, Gigli GL, Lanzetta P, Valente M
Cells 2023 Sep 29;12(19) doi: 10.3390/cells12192380. PMID: 37830595Free PMC Article
Clinical, histological, and molecular features of gliomas in adults with neurofibromatosis type 1.
Romo CG, Piotrowski AF, Campian JL, Diarte J, Rodriguez FJ, Bale TA, Dahiya S, Gutmann DH, Lucas CG, Prichett L, Mellinghoff I, Blakeley JO
Neuro Oncol 2023 Aug 3;25(8):1474-1486. doi: 10.1093/neuonc/noad033. PMID: 36840626Free PMC Article
A phase II trial of selumetinib in children with recurrent optic pathway and hypothalamic low-grade glioma without NF1: a Pediatric Brain Tumor Consortium study.
Fangusaro J, Onar-Thomas A, Poussaint TY, Wu S, Ligon AH, Lindeman N, Campagne O, Banerjee A, Gururangan S, Kilburn LB, Goldman S, Qaddoumi I, Baxter P, Vezina G, Bregman C, Patay Z, Jones JY, Stewart CF, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Neuro Oncol 2021 Oct 1;23(10):1777-1788. doi: 10.1093/neuonc/noab047. PMID: 33631016Free PMC Article
Pediatric Optic Pathway/Hypothalamic Glioma.
Aihara Y, Chiba K, Eguchi S, Amano K, Kawamata T
Neurol Med Chir (Tokyo) 2018 Jan 15;58(1):1-9. Epub 2017 Nov 9 doi: 10.2176/nmc.ra.2017-0081. PMID: 29118304Free PMC Article
Optic pathway glioma of childhood.
Rasool N, Odel JG, Kazim M
Curr Opin Ophthalmol 2017 May;28(3):289-295. doi: 10.1097/ICU.0000000000000370. PMID: 28257299

Clinical prediction guides

Visual outcomes and predictors in optic pathway glioma: a single centre study.
Bowman R, Walters B, Smith V, Prise KL, Handley SE, Green K, Mankad K, O'Hare P, Dahl C, Jorgensen M, Opocher E, Hargrave D, Thompson DA
Eye (Lond) 2023 Apr;37(6):1178-1183. Epub 2022 May 13 doi: 10.1038/s41433-022-02096-1. PMID: 35562551Free PMC Article
NEUROFIBROMATOSIS TYPE 1 AND OPTIC PATHWAY GLIOMA.
Siwá A, Autrata R, Vejmělková K, Pavelka Z, Zitterbart K
Cesk Slov Oftalmol 2019 Winter;75(4):200-208. doi: 10.31348/2019/4/4. PMID: 32397722
Neurological malignancies in neurofibromatosis type 1.
Eoli M, Saletti V, Finocchiaro G
Curr Opin Oncol 2019 Nov;31(6):554-561. doi: 10.1097/CCO.0000000000000576. PMID: 31436563
Clinical Presentation and Outcome of Patients With Optic Pathway Glioma.
Robert-Boire V, Rosca L, Samson Y, Ospina LH, Perreault S
Pediatr Neurol 2017 Oct;75:55-60. Epub 2017 Jul 6 doi: 10.1016/j.pediatrneurol.2017.06.019. PMID: 28847625
Phase II Weekly Vinblastine for Chemotherapy-Naïve Children With Progressive Low-Grade Glioma: A Canadian Pediatric Brain Tumor Consortium Study.
Lassaletta A, Scheinemann K, Zelcer SM, Hukin J, Wilson BA, Jabado N, Carret AS, Lafay-Cousin L, Larouche V, Hawkins CE, Pond GR, Poskitt K, Keene D, Johnston DL, Eisenstat DD, Krishnatry R, Mistry M, Arnoldo A, Ramaswamy V, Huang A, Bartels U, Tabori U, Bouffet E
J Clin Oncol 2016 Oct 10;34(29):3537-3543. doi: 10.1200/JCO.2016.68.1585. PMID: 27573663

Recent systematic reviews

Novel "T-Dimension" Therapies for Pediatric Optic Pathway Glioma: A Timely, Targeted, and Tailored Treatment Trend.
Giotta Lucifero A, Elbabaa SK, Baldoncini M, Bruno N, Savasta S, Marseglia GL, Luzzi S
Pediatr Neurosurg 2022;57(3):161-174. Epub 2022 May 4 doi: 10.1159/000524873. PMID: 35588700
The diagnostic accuracy and prognostic value of OCT for the evaluation of the visual function in children with a brain tumour: A systematic review.
Nuijts MA, Imhof SM, Veldhuis N, Dekkers CC, Schouten-van Meeteren AYN, Stegeman I
PLoS One 2021;16(12):e0261631. Epub 2021 Dec 23 doi: 10.1371/journal.pone.0261631. PMID: 34941930Free PMC Article
Impact of systemic anticancer therapy in pediatric optic pathway glioma on visual function: A systematic review.
Bennebroek CAM, Wijninga LE, Limpens J, Schouten-van Meeteren AYN, Saeed P
PLoS One 2021;16(10):e0258548. Epub 2021 Oct 21 doi: 10.1371/journal.pone.0258548. PMID: 34673789Free PMC Article
Café-au-lait Macules and Neurofibromatosis Type 1: A Review of the Literature.
Bernier A, Larbrisseau A, Perreault S
Pediatr Neurol 2016 Jul;60:24-29.e1. Epub 2016 Mar 19 doi: 10.1016/j.pediatrneurol.2016.03.003. PMID: 27212418
Does chemotherapy affect the visual outcome in children with optic pathway glioma? A systematic review of the evidence.
Moreno L, Bautista F, Ashley S, Duncan C, Zacharoulis S
Eur J Cancer 2010 Aug;46(12):2253-9. Epub 2010 Apr 17 doi: 10.1016/j.ejca.2010.03.028. PMID: 20400294

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